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Protein

[PSI+] induction protein 2

Gene

PIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Seems to be able to provoque the non-Mendelian trait [PIN+] which is required for the de novo appearance of the [PSI+] prion.

Keywords - Molecular functioni

Prion

Enzyme and pathway databases

BioCyciYEAST:G3O-33635-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
[PSI+] induction protein 2
Gene namesi
Name:PIN2
Ordered Locus Names:YOR104W
ORF Names:YOR3214W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR104W.
SGDiS000005630. PIN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282[PSI+] induction protein 2PRO_0000058442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Modified residuei141 – 1411PhosphothreonineCombined sources
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ12057.

PTM databases

iPTMnetiQ12057.
SwissPalmiQ12057.

Interactioni

Protein-protein interaction databases

BioGridi34501. 27 interactions.
DIPiDIP-4459N.
IntActiQ12057. 12 interactions.
MINTiMINT-561499.

Structurei

3D structure databases

ProteinModelPortaliQ12057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000115548.
InParanoidiQ12057.
OMAiTMETERF.
OrthoDBiEOG7WHHN3.

Sequencei

Sequence statusi: Complete.

Q12057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVCKLKEIV PLFPRSSFTD GVVSTGKSFR SWDTCMDNKA CKIIAIVGIV
60 70 80 90 100
LACILVIWLI GGLLTCFRQG VTGIGQFICW CCRCSNDRNG NNTMPVNEGF
110 120 130 140 150
SRVNMGVAPP STVIYQPIQQ PESAYYRNDA KNDTFYDEVK TPSNEVYELE
160 170 180 190 200
EDFDLEKQKE KTRKKQQKER NKEGRSPSRV APLVYEEENF EGSSPQPQYD
210 220 230 240 250
ARNSFIQNAA NTGSNNAHVA SQSPIFDISD YGENYYYDNN NINNNLQGNS
260 270 280
YNTPSSNHRS PYPTENYQSY QGYKPNQSDR YY
Length:282
Mass (Da):32,084
Last modified:November 1, 1996 - v1
Checksum:iB60FC4E951D2DC28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64025.1.
Z75012 Genomic DNA. Translation: CAA99301.1.
AY557759 Genomic DNA. Translation: AAS56085.1.
BK006948 Genomic DNA. Translation: DAA10880.1.
PIRiS61663.
RefSeqiNP_014747.1. NM_001183523.1.

Genome annotation databases

EnsemblFungiiYOR104W; YOR104W; YOR104W.
GeneIDi854271.
KEGGisce:YOR104W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64025.1.
Z75012 Genomic DNA. Translation: CAA99301.1.
AY557759 Genomic DNA. Translation: AAS56085.1.
BK006948 Genomic DNA. Translation: DAA10880.1.
PIRiS61663.
RefSeqiNP_014747.1. NM_001183523.1.

3D structure databases

ProteinModelPortaliQ12057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34501. 27 interactions.
DIPiDIP-4459N.
IntActiQ12057. 12 interactions.
MINTiMINT-561499.

PTM databases

iPTMnetiQ12057.
SwissPalmiQ12057.

Proteomic databases

MaxQBiQ12057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR104W; YOR104W; YOR104W.
GeneIDi854271.
KEGGisce:YOR104W.

Organism-specific databases

EuPathDBiFungiDB:YOR104W.
SGDiS000005630. PIN2.

Phylogenomic databases

HOGENOMiHOG000115548.
InParanoidiQ12057.
OMAiTMETERF.
OrthoDBiEOG7WHHN3.

Enzyme and pathway databases

BioCyciYEAST:G3O-33635-MONOMER.

Miscellaneous databases

NextBioi976224.
PROiQ12057.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Prions affect the appearance of other prions: the story of [PIN(+)]."
    Derkatch I.L., Bradley M.E., Hong J.Y., Liebman S.W.
    Cell 106:171-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, PRION FORMATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.

Entry informationi

Entry nameiPIN2_YEAST
AccessioniPrimary (citable) accession number: Q12057
Secondary accession number(s): D6W2G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.