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Protein

[PSI+] induction protein 2

Gene

PIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known. Seems to be able to provoque the non-Mendelian trait [PIN+] which is required for the de novo appearance of the [PSI+] prion.

Miscellaneous

Present with 996 molecules/cell in log phase SD medium.1 Publication

Keywordsi

Molecular functionPrion

Enzyme and pathway databases

BioCyciYEAST:G3O-33635-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
[PSI+] induction protein 2
Gene namesi
Name:PIN2
Ordered Locus Names:YOR104W
ORF Names:YOR3214W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR104W
SGDiS000005630 PIN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584421 – 282[PSI+] induction protein 2Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei141PhosphothreonineCombined sources1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ12057
PaxDbiQ12057
PRIDEiQ12057

PTM databases

iPTMnetiQ12057
SwissPalmiQ12057

Interactioni

Protein-protein interaction databases

BioGridi34501, 96 interactors
DIPiDIP-4459N
IntActiQ12057, 14 interactors
MINTiQ12057
STRINGi4932.YOR104W

Structurei

3D structure databases

ProteinModelPortaliQ12057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000115548
InParanoidiQ12057
OMAiTMETERF
OrthoDBiEOG092C56NP

Family and domain databases

InterProiView protein in InterPro
IPR037504 PSI_induc_2
PANTHERiPTHR40018 PTHR40018, 1 hit

Sequencei

Sequence statusi: Complete.

Q12057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVCKLKEIV PLFPRSSFTD GVVSTGKSFR SWDTCMDNKA CKIIAIVGIV
60 70 80 90 100
LACILVIWLI GGLLTCFRQG VTGIGQFICW CCRCSNDRNG NNTMPVNEGF
110 120 130 140 150
SRVNMGVAPP STVIYQPIQQ PESAYYRNDA KNDTFYDEVK TPSNEVYELE
160 170 180 190 200
EDFDLEKQKE KTRKKQQKER NKEGRSPSRV APLVYEEENF EGSSPQPQYD
210 220 230 240 250
ARNSFIQNAA NTGSNNAHVA SQSPIFDISD YGENYYYDNN NINNNLQGNS
260 270 280
YNTPSSNHRS PYPTENYQSY QGYKPNQSDR YY
Length:282
Mass (Da):32,084
Last modified:November 1, 1996 - v1
Checksum:iB60FC4E951D2DC28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64025.1
Z75012 Genomic DNA Translation: CAA99301.1
AY557759 Genomic DNA Translation: AAS56085.1
BK006948 Genomic DNA Translation: DAA10880.1
PIRiS61663
RefSeqiNP_014747.1, NM_001183523.1

Genome annotation databases

EnsemblFungiiYOR104W; YOR104W; YOR104W
GeneIDi854271
KEGGisce:YOR104W

Similar proteinsi

Entry informationi

Entry nameiPIN2_YEAST
AccessioniPrimary (citable) accession number: Q12057
Secondary accession number(s): D6W2G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health