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Protein

Adenylate kinase isoenzyme 6 homolog FAP7

Gene

FAP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (By similarity). Involved in 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress.UniRule annotation3 Publications

Miscellaneous

Present with 8350 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44AMPUniRule annotation1
Binding sitei84ATPUniRule annotation1
Binding sitei110ATPUniRule annotation1
Binding sitei114ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22ATPUniRule annotation6

GO - Molecular functioni

  • adenylate kinase activity Source: SGD
  • ATPase activity Source: SGD
  • ATP binding Source: GO_Central

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionKinase, Transferase
Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29558-MONOMER
ReactomeiR-SCE-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6 homolog FAP7UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
POS9-activating factor 7
Gene namesi
Name:FAP7
Ordered Locus Names:YDL166C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL166C
SGDiS000002325 FAP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19G → S: Sensitive to hydrogen peroxide. 1 Publication1
Mutagenesisi20K → R: Decreases the processing of 20S rRNA. 1 Publication1
Mutagenesisi21S → G: Sensitive to hydrogen peroxide. 1 Publication1
Mutagenesisi82D → A: Decreases the processing of 20S rRNA; when associated with A-84. 1 Publication1
Mutagenesisi84H → A: Decreases the processing of 20S rRNA; when associated with A-82. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539021 – 197Adenylate kinase isoenzyme 6 homolog FAP7Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphotyrosineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12055
PaxDbiQ12055
PRIDEiQ12055

PTM databases

iPTMnetiQ12055

Interactioni

Subunit structurei

Interacts with RPS14B. Not a structural component of 43S pre-ribosomes, but transiently interacts with them with them by binding to RPS14.1 Publication

Protein-protein interaction databases

BioGridi31899, 55 interactors
DIPiDIP-4793N
IntActiQ12055, 23 interactors
STRINGi4932.YDL166C

Structurei

3D structure databases

ProteinModelPortaliQ12055
SMRiQ12055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 61NMPbindUniRule annotationAdd BLAST24
Regioni113 – 123LIDUniRule annotationAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 35Nuclear localization signalSequence analysis8

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000015930
HOGENOMiHOG000224472
InParanoidiQ12055
KOiK18532
OMAiDNVQCEI
OrthoDBiEOG092C5GXJ

Family and domain databases

HAMAPiMF_00039 Adenylate_kinase_AK6, 1 hit
InterProiView protein in InterPro
IPR020618 Adenyl_kinase_AK6
IPR027417 P-loop_NTPase
PANTHERiPTHR12595:SF0 PTHR12595:SF0, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q12055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARRYGPNI IVTGTPGCGK SSTCEFLKNK LKDYKYYNIS DFAKDNDCFE
60 70 80 90 100
GYDEGRKSHI VDEDKLLDML EPLLRQGNSI VDWHVNDVFP ERLIDLVVVL
110 120 130 140 150
RCDNSNLYSR LHARGYHDSK IEENLDAEIM GVVKQDAVES YEPHIVVELQ
160 170 180 190
SDTKEDMVSN VSRIVAWEKM WLEQHPDGVT NEYQGPRSDD EDDEDSE
Length:197
Mass (Da):22,723
Last modified:November 1, 1996 - v1
Checksum:i836A25B0D7E2633C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80I → V in AAS56894 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67750 Genomic DNA Translation: CAA91580.1
Z74214 Genomic DNA Translation: CAA98740.1
AY558568 Genomic DNA Translation: AAS56894.1
BK006938 Genomic DNA Translation: DAA11695.1
PIRiS61047
RefSeqiNP_010115.1, NM_001180226.1

Genome annotation databases

EnsemblFungiiYDL166C; YDL166C; YDL166C
GeneIDi851388
KEGGisce:YDL166C

Similar proteinsi

Entry informationi

Entry nameiKAD6_YEAST
AccessioniPrimary (citable) accession number: Q12055
Secondary accession number(s): D6VRI5, E9P8W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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