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Protein

Spindle pole body-associated protein VIK1

Gene

VIK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.2 Publications

GO - Molecular functioni

  • microtubule binding Source: SGD

GO - Biological processi

  • microtubule-based process Source: SGD
  • mitotic sister chromatid cohesion Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-34138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle pole body-associated protein VIK1
Alternative name(s):
Vegetative interaction with KAR3 protein 1
Gene namesi
Name:VIK1
Ordered Locus Names:YPL253C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL253C.
SGDiS000006174. VIK1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: SGD
  • nucleus Source: UniProtKB-SubCell
  • spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Spindle pole body-associated protein VIK1PRO_0000270929Add
BLAST

Proteomic databases

MaxQBiQ12045.

Interactioni

Subunit structurei

Interacts with KAR3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KAR3P171194EBI-38784,EBI-9499

GO - Molecular functioni

  • microtubule binding Source: SGD

Protein-protein interaction databases

BioGridi35910. 61 interactions.
DIPiDIP-2397N.
IntActiQ12045. 4 interactions.
MINTiMINT-401672.

Structurei

Secondary structure

1
647
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi353 – 37220Combined sources
Beta strandi376 – 3816Combined sources
Helixi383 – 3853Combined sources
Beta strandi390 – 3934Combined sources
Turni394 – 3974Combined sources
Beta strandi398 – 4014Combined sources
Turni402 – 4043Combined sources
Beta strandi407 – 4093Combined sources
Beta strandi411 – 4155Combined sources
Turni416 – 4183Combined sources
Helixi421 – 4277Combined sources
Helixi430 – 4389Combined sources
Beta strandi443 – 4486Combined sources
Helixi454 – 46512Combined sources
Helixi470 – 4745Combined sources
Beta strandi475 – 48511Combined sources
Beta strandi486 – 4883Combined sources
Beta strandi490 – 4923Combined sources
Beta strandi506 – 5094Combined sources
Beta strandi514 – 5185Combined sources
Beta strandi521 – 5255Combined sources
Helixi526 – 5294Combined sources
Turni532 – 5354Combined sources
Beta strandi546 – 55712Combined sources
Beta strandi570 – 5778Combined sources
Helixi580 – 59112Combined sources
Helixi599 – 61012Combined sources
Beta strandi614 – 6196Combined sources
Helixi622 – 6243Combined sources
Helixi625 – 63814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O0AX-ray1.60A353-647[»]
4ETPX-ray2.30B341-647[»]
ProteinModelPortaliQ12045.
SMRiQ12045. Positions 324-640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12045.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili202 – 350149Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00530000068675.
InParanoidiQ12045.
OMAiRRIENTI.
OrthoDBiEOG7T4MWM.

Family and domain databases

InterProiIPR031852. Vik1/Cik1_MT-bd.
[Graphical view]
PfamiPF16796. Microtub_bd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQQNKHAF LSKNRIFHNP DNVSSSKSRN LMDITNTTNT MNGSRPSSMK
60 70 80 90 100
SSLALPPVKD SFPSVSRSAS LNINMSKIKD LKDRQDKIRF QRHTLRTQLI
110 120 130 140 150
ECEREIKTIK FRDLNKSRFE LYKKKSKQAK YLKQVRDLTQ NLNSKDGERA
160 170 180 190 200
DLIKKNKSAL ATLQAELDQN LILKRQESQE LYNNKLIFWE NELQIMENVE
210 220 230 240 250
PDHEITEEIS QLKKTLQELN INWANLQKQN LERQVNHESQ LRKDFIAFKE
260 270 280 290 300
AKLKSMENLT NKHRELLDQI ATLQSESEKL HKEIMDIDRQ AEYSEQNISE
310 320 330 340 350
INENIKQLEL ANNPLISKSL QNSQDLEHLQ NQMENLKEMA SKQEKFYNDT
360 370 380 390 400
YNTVEKELLR SRRLENSIIE QKGTMRCYAY VMEQNLPENL LFDYENGVIT
410 420 430 440 450
QGLSEHVYKF NRVIPHLKVS EDKFFTQEYS VYHDMCLNQK KNFNLISLST
460 470 480 490 500
TPHGSLRESL IKFLAEKDTI YQKQYVITLQ FVFLSDDEFS QDMLLDYSHN
510 520 530 540 550
DKDSIKLKFE KHSISLDSKL VIIENGLEDL PLNFSCDEHP NLPHSGMGII
560 570 580 590 600
KVQFFPRDSK SDGNNDPVPV DFYFIELNNL KSIEQFDKSI FKKESCETPI
610 620 630 640
ALVLKKLISD TKSFFLLNLN DSKNVNKLLT ISEEVQTQLC KRKKKLT
Length:647
Mass (Da):75,730
Last modified:November 1, 1996 - v1
Checksum:iA6E61C51CC10B8EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73609 Genomic DNA. Translation: CAA97978.1.
Z67751 Genomic DNA. Translation: CAA91591.1.
Z73608 Genomic DNA. Translation: CAA97977.1.
BK006949 Genomic DNA. Translation: DAA11184.1.
PIRiS61011.
RefSeqiNP_015070.1. NM_001184067.1.

Genome annotation databases

EnsemblFungiiYPL253C; YPL253C; YPL253C.
GeneIDi855822.
KEGGisce:YPL253C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73609 Genomic DNA. Translation: CAA97978.1.
Z67751 Genomic DNA. Translation: CAA91591.1.
Z73608 Genomic DNA. Translation: CAA97977.1.
BK006949 Genomic DNA. Translation: DAA11184.1.
PIRiS61011.
RefSeqiNP_015070.1. NM_001184067.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O0AX-ray1.60A353-647[»]
4ETPX-ray2.30B341-647[»]
ProteinModelPortaliQ12045.
SMRiQ12045. Positions 324-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35910. 61 interactions.
DIPiDIP-2397N.
IntActiQ12045. 4 interactions.
MINTiMINT-401672.

Proteomic databases

MaxQBiQ12045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL253C; YPL253C; YPL253C.
GeneIDi855822.
KEGGisce:YPL253C.

Organism-specific databases

EuPathDBiFungiDB:YPL253C.
SGDiS000006174. VIK1.

Phylogenomic databases

GeneTreeiENSGT00530000068675.
InParanoidiQ12045.
OMAiRRIENTI.
OrthoDBiEOG7T4MWM.

Enzyme and pathway databases

BioCyciYEAST:G3O-34138-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12045.
NextBioi980368.
PROiQ12045.

Family and domain databases

InterProiIPR031852. Vik1/Cik1_MT-bd.
[Graphical view]
PfamiPF16796. Microtub_bd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p."
    Manning B.D., Barrett J.G., Wallace J.A., Granok H., Snyder M.
    J. Cell Biol. 144:1219-1233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KAR3, SUBCELLULAR LOCATION.
  4. "The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae."
    Shanks R.M.Q., Kamieniecki R.J., Dawson D.S.
    Genetics 159:939-951(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiVIK1_YEAST
AccessioniPrimary (citable) accession number: Q12045
Secondary accession number(s): D6W3B8, Q7LGU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.