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Q12044

- RCN2_YEAST

UniProt

Q12044 - RCN2_YEAST

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Protein

Regulator of calcineurin 2

Gene

RCN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-33720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of calcineurin 2
Alternative name(s):
Weak suppressor of PAT1 ts protein 1
Gene namesi
Name:RCN2
Synonyms:WSP1
Ordered Locus Names:YOR220W
ORF Names:YOR50-10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR220w.
SGDiS000005746. RCN2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Regulator of calcineurin 2PRO_0000237641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041Phosphoserine2 Publications
Modified residuei110 – 1101Phosphoserine2 Publications
Modified residuei132 – 1321Phosphothreonine3 Publications
Modified residuei152 – 1521Phosphoserine2 Publications
Modified residuei157 – 1571Phosphoserine1 Publication
Modified residuei160 – 1601Phosphoserine2 Publications
Modified residuei183 – 1831Phosphoserine3 Publications
Modified residuei187 – 1871Phosphoserine1 Publication
Modified residuei193 – 1931Phosphoserine2 Publications
Modified residuei201 – 2011Phosphoserine1 Publication
Modified residuei255 – 2551Phosphoserine2 Publications

Post-translational modificationi

Phosphorylation of Ser-152 and Ser-160 is induced 2-fold in response to mating pheromone.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12044.
PaxDbiQ12044.
PeptideAtlasiQ12044.

Expressioni

Gene expression databases

GenevestigatoriQ12044.

Interactioni

Protein-protein interaction databases

BioGridi34614. 21 interactions.
DIPiDIP-1996N.
IntActiQ12044. 4 interactions.
MINTiMINT-384402.
STRINGi4932.YOR220W.

Structurei

3D structure databases

ProteinModelPortaliQ12044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi141 – 20464Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG44665.
HOGENOMiHOG000066002.
InParanoidiQ12044.
OMAiRCAREHY.
OrthoDBiEOG7GTTGZ.

Sequencei

Sequence statusi: Complete.

Q12044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANQKQMRTQ ILITDIPSGK FTSKWPTQLE KTLFKEQFPN LQSHLQYYTP
60 70 80 90 100
LPFLNRIIII FDNEDDTLQV FKFLQELLAK ENSGPMKLFV TESLLNNQHP
110 120 130 140 150
RSRSTDDAVS LQDNNLALLE DHRNKPLLSI NTDPGVTGVD SSSLNKGGSS
160 170 180 190 200
LSPDKSSLES PTMLKLSTDS KPFSYQEPLP KLSRSSSSTS NLSLNRSSQT
210 220 230 240 250
SLPSQLENKD KSASGTKCLF ASKPLGLTID TSTRSNAASC TENDVNATAS
260
NPPKSPSITV NEFFH
Length:265
Mass (Da):29,256
Last modified:November 1, 1996 - v1
Checksum:i4A184C5C1218A617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63183.1.
Z75128 Genomic DNA. Translation: CAA99438.1.
AY557757 Genomic DNA. Translation: AAS56083.1.
BK006948 Genomic DNA. Translation: DAA10991.1.
PIRiS60947.
RefSeqiNP_014863.1. NM_001183639.1.

Genome annotation databases

EnsemblFungiiYOR220W; YOR220W; YOR220W.
GeneIDi854395.
KEGGisce:YOR220W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63183.1 .
Z75128 Genomic DNA. Translation: CAA99438.1 .
AY557757 Genomic DNA. Translation: AAS56083.1 .
BK006948 Genomic DNA. Translation: DAA10991.1 .
PIRi S60947.
RefSeqi NP_014863.1. NM_001183639.1.

3D structure databases

ProteinModelPortali Q12044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34614. 21 interactions.
DIPi DIP-1996N.
IntActi Q12044. 4 interactions.
MINTi MINT-384402.
STRINGi 4932.YOR220W.

Proteomic databases

MaxQBi Q12044.
PaxDbi Q12044.
PeptideAtlasi Q12044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR220W ; YOR220W ; YOR220W .
GeneIDi 854395.
KEGGi sce:YOR220W.

Organism-specific databases

CYGDi YOR220w.
SGDi S000005746. RCN2.

Phylogenomic databases

eggNOGi NOG44665.
HOGENOMi HOG000066002.
InParanoidi Q12044.
OMAi RCAREHY.
OrthoDBi EOG7GTTGZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-33720-MONOMER.

Miscellaneous databases

NextBioi 976559.

Gene expression databases

Genevestigatori Q12044.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
    Galisson F., Dujon B.
    Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; THR-132; SER-152; SER-160 AND SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110; THR-132; SER-193 AND SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-110; THR-132; SER-152; SER-157; SER-160; SER-183; SER-187; SER-193; SER-201 AND SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRCN2_YEAST
AccessioniPrimary (citable) accession number: Q12044
Secondary accession number(s): D6W2S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 967 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3