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Q12044

- RCN2_YEAST

UniProt

Q12044 - RCN2_YEAST

Protein

Regulator of calcineurin 2

Gene

RCN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33720-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of calcineurin 2
    Alternative name(s):
    Weak suppressor of PAT1 ts protein 1
    Gene namesi
    Name:RCN2
    Synonyms:WSP1
    Ordered Locus Names:YOR220W
    ORF Names:YOR50-10
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR220w.
    SGDiS000005746. RCN2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Regulator of calcineurin 2PRO_0000237641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei104 – 1041Phosphoserine2 Publications
    Modified residuei110 – 1101Phosphoserine2 Publications
    Modified residuei132 – 1321Phosphothreonine3 Publications
    Modified residuei152 – 1521Phosphoserine2 Publications
    Modified residuei157 – 1571Phosphoserine1 Publication
    Modified residuei160 – 1601Phosphoserine2 Publications
    Modified residuei183 – 1831Phosphoserine3 Publications
    Modified residuei187 – 1871Phosphoserine1 Publication
    Modified residuei193 – 1931Phosphoserine2 Publications
    Modified residuei201 – 2011Phosphoserine1 Publication
    Modified residuei255 – 2551Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylation of Ser-152 and Ser-160 is induced 2-fold in response to mating pheromone.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12044.
    PaxDbiQ12044.
    PeptideAtlasiQ12044.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12044.

    Interactioni

    Protein-protein interaction databases

    BioGridi34614. 19 interactions.
    DIPiDIP-1996N.
    IntActiQ12044. 4 interactions.
    MINTiMINT-384402.
    STRINGi4932.YOR220W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12044.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi141 – 20464Ser-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG44665.
    HOGENOMiHOG000066002.
    OMAiRCAREHY.
    OrthoDBiEOG7GTTGZ.

    Sequencei

    Sequence statusi: Complete.

    Q12044-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANQKQMRTQ ILITDIPSGK FTSKWPTQLE KTLFKEQFPN LQSHLQYYTP    50
    LPFLNRIIII FDNEDDTLQV FKFLQELLAK ENSGPMKLFV TESLLNNQHP 100
    RSRSTDDAVS LQDNNLALLE DHRNKPLLSI NTDPGVTGVD SSSLNKGGSS 150
    LSPDKSSLES PTMLKLSTDS KPFSYQEPLP KLSRSSSSTS NLSLNRSSQT 200
    SLPSQLENKD KSASGTKCLF ASKPLGLTID TSTRSNAASC TENDVNATAS 250
    NPPKSPSITV NEFFH 265
    Length:265
    Mass (Da):29,256
    Last modified:November 1, 1996 - v1
    Checksum:i4A184C5C1218A617
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92441 Genomic DNA. Translation: CAA63183.1.
    Z75128 Genomic DNA. Translation: CAA99438.1.
    AY557757 Genomic DNA. Translation: AAS56083.1.
    BK006948 Genomic DNA. Translation: DAA10991.1.
    PIRiS60947.
    RefSeqiNP_014863.1. NM_001183639.1.

    Genome annotation databases

    EnsemblFungiiYOR220W; YOR220W; YOR220W.
    GeneIDi854395.
    KEGGisce:YOR220W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92441 Genomic DNA. Translation: CAA63183.1 .
    Z75128 Genomic DNA. Translation: CAA99438.1 .
    AY557757 Genomic DNA. Translation: AAS56083.1 .
    BK006948 Genomic DNA. Translation: DAA10991.1 .
    PIRi S60947.
    RefSeqi NP_014863.1. NM_001183639.1.

    3D structure databases

    ProteinModelPortali Q12044.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34614. 19 interactions.
    DIPi DIP-1996N.
    IntActi Q12044. 4 interactions.
    MINTi MINT-384402.
    STRINGi 4932.YOR220W.

    Proteomic databases

    MaxQBi Q12044.
    PaxDbi Q12044.
    PeptideAtlasi Q12044.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR220W ; YOR220W ; YOR220W .
    GeneIDi 854395.
    KEGGi sce:YOR220W.

    Organism-specific databases

    CYGDi YOR220w.
    SGDi S000005746. RCN2.

    Phylogenomic databases

    eggNOGi NOG44665.
    HOGENOMi HOG000066002.
    OMAi RCAREHY.
    OrthoDBi EOG7GTTGZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33720-MONOMER.

    Miscellaneous databases

    NextBioi 976559.

    Gene expression databases

    Genevestigatori Q12044.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
      Galisson F., Dujon B.
      Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; THR-132; SER-152; SER-160 AND SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110; THR-132; SER-193 AND SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-110; THR-132; SER-152; SER-157; SER-160; SER-183; SER-187; SER-193; SER-201 AND SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRCN2_YEAST
    AccessioniPrimary (citable) accession number: Q12044
    Secondary accession number(s): D6W2S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 967 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3