Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lethal(2) giant larvae protein homolog SRO7

Gene

SRO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.7 Publications

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: SGD
  • SNARE binding Source: SGD
  • syntaxin binding Source: GO_Central

GO - Biological processi

  • establishment of cell polarity Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • regulation of exocytosis Source: GO_Central
  • regulation of protein secretion Source: GO_Central
  • small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-34191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(2) giant larvae protein homolog SRO7
Alternative name(s):
Polarity protein SRO7
Sodium protection protein 1
Suppressor of RHO3 protein 7
Gene namesi
Name:SRO7
Synonyms:SNI1, SOP1
Ordered Locus Names:YPR032W
ORF Names:YP9367.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR032W.
SGDiS000006236. SRO7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • mating projection tip Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10331033Lethal(2) giant larvae protein homolog SRO7PRO_0000072008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei591 – 5911PhosphoserineCombined sources
Modified residuei602 – 6021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12038.

PTM databases

iPTMnetiQ12038.

Interactioni

Subunit structurei

Interacts with MYO2 and SEC9.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC9P403573EBI-17573,EBI-16904

GO - Molecular functioni

  • Rab GTPase binding Source: SGD
  • SNARE binding Source: SGD
  • syntaxin binding Source: GO_Central

Protein-protein interaction databases

BioGridi36210. 301 interactions.
DIPiDIP-2581N.
IntActiQ12038. 6 interactions.
MINTiMINT-426990.

Structurei

Secondary structure

1
1033
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi66 – 7510Combined sources
Beta strandi80 – 867Combined sources
Turni87 – 904Combined sources
Beta strandi91 – 966Combined sources
Beta strandi99 – 1046Combined sources
Beta strandi110 – 1145Combined sources
Beta strandi121 – 1277Combined sources
Turni128 – 1303Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi140 – 1456Combined sources
Turni146 – 1483Combined sources
Beta strandi150 – 1567Combined sources
Beta strandi161 – 1655Combined sources
Beta strandi171 – 1777Combined sources
Beta strandi182 – 1865Combined sources
Turni187 – 1904Combined sources
Beta strandi191 – 1977Combined sources
Helixi200 – 2045Combined sources
Beta strandi207 – 2093Combined sources
Beta strandi216 – 2205Combined sources
Beta strandi223 – 2308Combined sources
Beta strandi235 – 2395Combined sources
Turni240 – 2434Combined sources
Beta strandi244 – 2496Combined sources
Beta strandi274 – 2796Combined sources
Beta strandi283 – 2908Combined sources
Beta strandi295 – 2995Combined sources
Turni300 – 3023Combined sources
Beta strandi305 – 3095Combined sources
Beta strandi333 – 3419Combined sources
Beta strandi347 – 3559Combined sources
Beta strandi365 – 3728Combined sources
Helixi376 – 3783Combined sources
Helixi381 – 3899Combined sources
Beta strandi392 – 3976Combined sources
Beta strandi400 – 4034Combined sources
Beta strandi405 – 4106Combined sources
Helixi417 – 4204Combined sources
Beta strandi425 – 4317Combined sources
Beta strandi436 – 4405Combined sources
Turni441 – 4433Combined sources
Helixi450 – 4523Combined sources
Helixi455 – 4606Combined sources
Turni461 – 4633Combined sources
Beta strandi464 – 47310Combined sources
Helixi474 – 4829Combined sources
Beta strandi505 – 51410Combined sources
Beta strandi517 – 5259Combined sources
Turni528 – 5325Combined sources
Beta strandi535 – 5384Combined sources
Helixi539 – 5424Combined sources
Beta strandi546 – 5483Combined sources
Beta strandi551 – 5577Combined sources
Turni558 – 5614Combined sources
Beta strandi562 – 5676Combined sources
Beta strandi572 – 5798Combined sources
Helixi603 – 6053Combined sources
Beta strandi609 – 6124Combined sources
Helixi614 – 6163Combined sources
Beta strandi622 – 63110Combined sources
Beta strandi637 – 6437Combined sources
Beta strandi647 – 6537Combined sources
Beta strandi656 – 6627Combined sources
Turni663 – 6664Combined sources
Beta strandi667 – 6737Combined sources
Helixi674 – 6763Combined sources
Beta strandi685 – 69410Combined sources
Beta strandi698 – 70912Combined sources
Beta strandi712 – 72110Combined sources
Helixi723 – 7253Combined sources
Beta strandi727 – 73610Combined sources
Beta strandi745 – 7506Combined sources
Turni751 – 7533Combined sources
Helixi761 – 7655Combined sources
Helixi766 – 7694Combined sources
Beta strandi775 – 7806Combined sources
Beta strandi782 – 7887Combined sources
Beta strandi795 – 7995Combined sources
Beta strandi804 – 81512Combined sources
Beta strandi817 – 8193Combined sources
Beta strandi821 – 83111Combined sources
Beta strandi834 – 8407Combined sources
Turni841 – 8433Combined sources
Beta strandi846 – 8516Combined sources
Helixi858 – 8614Combined sources
Beta strandi872 – 8754Combined sources
Beta strandi877 – 88812Combined sources
Turni915 – 9173Combined sources
Helixi927 – 9359Combined sources
Helixi945 – 9495Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OAJX-ray2.40A61-962[»]
ProteinModelPortaliQ12038.
SMRiQ12038. Positions 62-951.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12038.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati81 – 11434WD 11 PublicationAdd
BLAST
Repeati121 – 15636WD 21 PublicationAdd
BLAST
Repeati161 – 19737WD 31 PublicationAdd
BLAST
Repeati216 – 24934WD 41 PublicationAdd
BLAST
Repeati274 – 30936WD 51 PublicationAdd
BLAST
Repeati333 – 39765WD 61 PublicationAdd
BLAST
Repeati405 – 44036WD 71 PublicationAdd
BLAST
Repeati464 – 53875WD 81 PublicationAdd
BLAST
Repeati552 – 63180WD 91 PublicationAdd
BLAST
Repeati638 – 67336WD 101 PublicationAdd
BLAST
Repeati685 – 73652WD 111 PublicationAdd
BLAST
Repeati745 – 79955WD 121 PublicationAdd
BLAST
Repeati804 – 85148WD 131 PublicationAdd
BLAST
Repeati865 – 88824WD 141 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 524Poly-Ser

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 14 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiQ12038.
KOiK08518.
OMAiHESGFIR.
OrthoDBiEOG092C096J.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGSKRLKNV KEAFKSLKGQ NSETPIENSK ASFKSKNSKT STISKDAKSS
60 70 80 90 100
SSLKIPISSN NKNKIFSLAE TNKYGMSSKP IAAAFDFTQN LLAIATVTGE
110 120 130 140 150
VHIYGQQQVE VVIKLEDRSA IKEMRFVKGI YLVVINAKDT VYVLSLYSQK
160 170 180 190 200
VLTTVFVPGK ITSIDTDASL DWMLIGLQNG SMIVYDIDRD QLSSFKLDNL
210 220 230 240 250
QKSSFFPAAR LSPIVSIQWN PRDIGTVLIS YEYVTLTYSL VENEIKQSFI
260 270 280 290 300
YELPPFAPGG DFSEKTNEKR TPKVIQSLYH PNSLHIITIH EDNSLVFWDA
310 320 330 340 350
NSGHMIMART VFETEINVPQ PDYIRDSSTN AAKISKVYWM CENNPEYTSL
360 370 380 390 400
LISHKSISRG DNQSLTMIDL GYTPRYSITS YEGMKNYYAN PKQMKIFPLP
410 420 430 440 450
TNVPIVNILP IPRQSPYFAG CHNPGLILLI LGNGEIETML YPSGIFTDKA
460 470 480 490 500
SLFPQNLSWL RPLATTSMAA SVPNKLWLGA LSAAQNKDYL LKGGVRTKRQ
510 520 530 540 550
KLPAEYGTAF ITGHSNGSVR IYDASHGDIQ DNASFEVNLS RTLNKAKELA
560 570 580 590 600
VDKISFAAET LELAVSIETG DVVLFKYEVN QFYSVENRPE SGDLEMNFRR
610 620 630 640 650
FSLNNTNGVL VDVRDRAPTG VRQGFMPSTA VHANKGKTSA INNSNIGFVG
660 670 680 690 700
IAYAAGSLML IDRRGPAIIY MENIREISGA QSACVTCIEF VIMEYGDDGY
710 720 730 740 750
SSILMVCGTD MGEVITYKIL PASGGKFDVQ LMDITNVTSK GPIHKIDAFS
760 770 780 790 800
KETKSSCLAT IPKMQNLSKG LCIPGIVLIT GFDDIRLITL GKSKSTHKGF
810 820 830 840 850
KYPLAATGLS YISTVEKNND RKNLTVIITL EINGHLRVFT IPDFKEQMSE
860 870 880 890 900
HIPFPIAAKY ITESSVLRNG DIAIRVSEFQ ASLFSTVKEQ DTLAPVSDTL
910 920 930 940 950
YINGIRIPYR PQVNSLQWAR GTVYCTPAQL NELLGGVNRP ASKYKESIIA
960 970 980 990 1000
EGSFSERSSD DNNANHPEHQ YTKPTRKGRN SSYGVLRNVS RAVETRWDAV
1010 1020 1030
EDRFNDYATA MGETMNEAVE QTGKDVMKGA LGF
Length:1,033
Mass (Da):114,513
Last modified:November 1, 1996 - v1
Checksum:iFFB0901883009815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA95028.1.
Z49274 Genomic DNA. Translation: CAA89286.1.
BK006949 Genomic DNA. Translation: DAA11458.1.
PIRiS54506.
RefSeqiNP_015357.1. NM_001184129.1.

Genome annotation databases

EnsemblFungiiYPR032W; YPR032W; YPR032W.
GeneIDi856144.
KEGGisce:YPR032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA95028.1.
Z49274 Genomic DNA. Translation: CAA89286.1.
BK006949 Genomic DNA. Translation: DAA11458.1.
PIRiS54506.
RefSeqiNP_015357.1. NM_001184129.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OAJX-ray2.40A61-962[»]
ProteinModelPortaliQ12038.
SMRiQ12038. Positions 62-951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36210. 301 interactions.
DIPiDIP-2581N.
IntActiQ12038. 6 interactions.
MINTiMINT-426990.

PTM databases

iPTMnetiQ12038.

Proteomic databases

MaxQBiQ12038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR032W; YPR032W; YPR032W.
GeneIDi856144.
KEGGisce:YPR032W.

Organism-specific databases

EuPathDBiFungiDB:YPR032W.
SGDiS000006236. SRO7.

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiQ12038.
KOiK08518.
OMAiHESGFIR.
OrthoDBiEOG092C096J.

Enzyme and pathway databases

BioCyciYEAST:G3O-34191-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12038.
PROiQ12038.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRO7_YEAST
AccessioniPrimary (citable) accession number: Q12038
Secondary accession number(s): D6W442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.