Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lethal(2) giant larvae protein homolog SRO7

Gene

SRO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.7 Publications

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: SGD
  • SNARE binding Source: SGD
  • syntaxin binding Source: GO_Central

GO - Biological processi

  • establishment of cell polarity Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • regulation of exocytosis Source: GO_Central
  • regulation of protein secretion Source: GO_Central
  • small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-34191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(2) giant larvae protein homolog SRO7
Alternative name(s):
Polarity protein SRO7
Sodium protection protein 1
Suppressor of RHO3 protein 7
Gene namesi
Name:SRO7
Synonyms:SNI1, SOP1
Ordered Locus Names:YPR032W
ORF Names:YP9367.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR032W.
SGDiS000006236. SRO7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • mating projection tip Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720081 – 1033Lethal(2) giant larvae protein homolog SRO7Add BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei591PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12038.
PRIDEiQ12038.

PTM databases

iPTMnetiQ12038.

Interactioni

Subunit structurei

Interacts with MYO2 and SEC9.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC9P403573EBI-17573,EBI-16904

GO - Molecular functioni

  • Rab GTPase binding Source: SGD
  • SNARE binding Source: SGD
  • syntaxin binding Source: GO_Central

Protein-protein interaction databases

BioGridi36210. 301 interactors.
DIPiDIP-2581N.
IntActiQ12038. 6 interactors.
MINTiMINT-426990.

Structurei

Secondary structure

11033
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 75Combined sources10
Beta strandi80 – 86Combined sources7
Turni87 – 90Combined sources4
Beta strandi91 – 96Combined sources6
Beta strandi99 – 104Combined sources6
Beta strandi110 – 114Combined sources5
Beta strandi121 – 127Combined sources7
Turni128 – 130Combined sources3
Beta strandi131 – 136Combined sources6
Beta strandi140 – 145Combined sources6
Turni146 – 148Combined sources3
Beta strandi150 – 156Combined sources7
Beta strandi161 – 165Combined sources5
Beta strandi171 – 177Combined sources7
Beta strandi182 – 186Combined sources5
Turni187 – 190Combined sources4
Beta strandi191 – 197Combined sources7
Helixi200 – 204Combined sources5
Beta strandi207 – 209Combined sources3
Beta strandi216 – 220Combined sources5
Beta strandi223 – 230Combined sources8
Beta strandi235 – 239Combined sources5
Turni240 – 243Combined sources4
Beta strandi244 – 249Combined sources6
Beta strandi274 – 279Combined sources6
Beta strandi283 – 290Combined sources8
Beta strandi295 – 299Combined sources5
Turni300 – 302Combined sources3
Beta strandi305 – 309Combined sources5
Beta strandi333 – 341Combined sources9
Beta strandi347 – 355Combined sources9
Beta strandi365 – 372Combined sources8
Helixi376 – 378Combined sources3
Helixi381 – 389Combined sources9
Beta strandi392 – 397Combined sources6
Beta strandi400 – 403Combined sources4
Beta strandi405 – 410Combined sources6
Helixi417 – 420Combined sources4
Beta strandi425 – 431Combined sources7
Beta strandi436 – 440Combined sources5
Turni441 – 443Combined sources3
Helixi450 – 452Combined sources3
Helixi455 – 460Combined sources6
Turni461 – 463Combined sources3
Beta strandi464 – 473Combined sources10
Helixi474 – 482Combined sources9
Beta strandi505 – 514Combined sources10
Beta strandi517 – 525Combined sources9
Turni528 – 532Combined sources5
Beta strandi535 – 538Combined sources4
Helixi539 – 542Combined sources4
Beta strandi546 – 548Combined sources3
Beta strandi551 – 557Combined sources7
Turni558 – 561Combined sources4
Beta strandi562 – 567Combined sources6
Beta strandi572 – 579Combined sources8
Helixi603 – 605Combined sources3
Beta strandi609 – 612Combined sources4
Helixi614 – 616Combined sources3
Beta strandi622 – 631Combined sources10
Beta strandi637 – 643Combined sources7
Beta strandi647 – 653Combined sources7
Beta strandi656 – 662Combined sources7
Turni663 – 666Combined sources4
Beta strandi667 – 673Combined sources7
Helixi674 – 676Combined sources3
Beta strandi685 – 694Combined sources10
Beta strandi698 – 709Combined sources12
Beta strandi712 – 721Combined sources10
Helixi723 – 725Combined sources3
Beta strandi727 – 736Combined sources10
Beta strandi745 – 750Combined sources6
Turni751 – 753Combined sources3
Helixi761 – 765Combined sources5
Helixi766 – 769Combined sources4
Beta strandi775 – 780Combined sources6
Beta strandi782 – 788Combined sources7
Beta strandi795 – 799Combined sources5
Beta strandi804 – 815Combined sources12
Beta strandi817 – 819Combined sources3
Beta strandi821 – 831Combined sources11
Beta strandi834 – 840Combined sources7
Turni841 – 843Combined sources3
Beta strandi846 – 851Combined sources6
Helixi858 – 861Combined sources4
Beta strandi872 – 875Combined sources4
Beta strandi877 – 888Combined sources12
Turni915 – 917Combined sources3
Helixi927 – 935Combined sources9
Helixi945 – 949Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OAJX-ray2.40A61-962[»]
ProteinModelPortaliQ12038.
SMRiQ12038.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12038.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 114WD 11 PublicationAdd BLAST34
Repeati121 – 156WD 21 PublicationAdd BLAST36
Repeati161 – 197WD 31 PublicationAdd BLAST37
Repeati216 – 249WD 41 PublicationAdd BLAST34
Repeati274 – 309WD 51 PublicationAdd BLAST36
Repeati333 – 397WD 61 PublicationAdd BLAST65
Repeati405 – 440WD 71 PublicationAdd BLAST36
Repeati464 – 538WD 81 PublicationAdd BLAST75
Repeati552 – 631WD 91 PublicationAdd BLAST80
Repeati638 – 673WD 101 PublicationAdd BLAST36
Repeati685 – 736WD 111 PublicationAdd BLAST52
Repeati745 – 799WD 121 PublicationAdd BLAST55
Repeati804 – 851WD 131 PublicationAdd BLAST48
Repeati865 – 888WD 141 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 52Poly-Ser4

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 14 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiQ12038.
KOiK08518.
OMAiHESGFIR.
OrthoDBiEOG092C096J.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGSKRLKNV KEAFKSLKGQ NSETPIENSK ASFKSKNSKT STISKDAKSS
60 70 80 90 100
SSLKIPISSN NKNKIFSLAE TNKYGMSSKP IAAAFDFTQN LLAIATVTGE
110 120 130 140 150
VHIYGQQQVE VVIKLEDRSA IKEMRFVKGI YLVVINAKDT VYVLSLYSQK
160 170 180 190 200
VLTTVFVPGK ITSIDTDASL DWMLIGLQNG SMIVYDIDRD QLSSFKLDNL
210 220 230 240 250
QKSSFFPAAR LSPIVSIQWN PRDIGTVLIS YEYVTLTYSL VENEIKQSFI
260 270 280 290 300
YELPPFAPGG DFSEKTNEKR TPKVIQSLYH PNSLHIITIH EDNSLVFWDA
310 320 330 340 350
NSGHMIMART VFETEINVPQ PDYIRDSSTN AAKISKVYWM CENNPEYTSL
360 370 380 390 400
LISHKSISRG DNQSLTMIDL GYTPRYSITS YEGMKNYYAN PKQMKIFPLP
410 420 430 440 450
TNVPIVNILP IPRQSPYFAG CHNPGLILLI LGNGEIETML YPSGIFTDKA
460 470 480 490 500
SLFPQNLSWL RPLATTSMAA SVPNKLWLGA LSAAQNKDYL LKGGVRTKRQ
510 520 530 540 550
KLPAEYGTAF ITGHSNGSVR IYDASHGDIQ DNASFEVNLS RTLNKAKELA
560 570 580 590 600
VDKISFAAET LELAVSIETG DVVLFKYEVN QFYSVENRPE SGDLEMNFRR
610 620 630 640 650
FSLNNTNGVL VDVRDRAPTG VRQGFMPSTA VHANKGKTSA INNSNIGFVG
660 670 680 690 700
IAYAAGSLML IDRRGPAIIY MENIREISGA QSACVTCIEF VIMEYGDDGY
710 720 730 740 750
SSILMVCGTD MGEVITYKIL PASGGKFDVQ LMDITNVTSK GPIHKIDAFS
760 770 780 790 800
KETKSSCLAT IPKMQNLSKG LCIPGIVLIT GFDDIRLITL GKSKSTHKGF
810 820 830 840 850
KYPLAATGLS YISTVEKNND RKNLTVIITL EINGHLRVFT IPDFKEQMSE
860 870 880 890 900
HIPFPIAAKY ITESSVLRNG DIAIRVSEFQ ASLFSTVKEQ DTLAPVSDTL
910 920 930 940 950
YINGIRIPYR PQVNSLQWAR GTVYCTPAQL NELLGGVNRP ASKYKESIIA
960 970 980 990 1000
EGSFSERSSD DNNANHPEHQ YTKPTRKGRN SSYGVLRNVS RAVETRWDAV
1010 1020 1030
EDRFNDYATA MGETMNEAVE QTGKDVMKGA LGF
Length:1,033
Mass (Da):114,513
Last modified:November 1, 1996 - v1
Checksum:iFFB0901883009815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA95028.1.
Z49274 Genomic DNA. Translation: CAA89286.1.
BK006949 Genomic DNA. Translation: DAA11458.1.
PIRiS54506.
RefSeqiNP_015357.1. NM_001184129.1.

Genome annotation databases

EnsemblFungiiYPR032W; YPR032W; YPR032W.
GeneIDi856144.
KEGGisce:YPR032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA. Translation: CAA95028.1.
Z49274 Genomic DNA. Translation: CAA89286.1.
BK006949 Genomic DNA. Translation: DAA11458.1.
PIRiS54506.
RefSeqiNP_015357.1. NM_001184129.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OAJX-ray2.40A61-962[»]
ProteinModelPortaliQ12038.
SMRiQ12038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36210. 301 interactors.
DIPiDIP-2581N.
IntActiQ12038. 6 interactors.
MINTiMINT-426990.

PTM databases

iPTMnetiQ12038.

Proteomic databases

MaxQBiQ12038.
PRIDEiQ12038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR032W; YPR032W; YPR032W.
GeneIDi856144.
KEGGisce:YPR032W.

Organism-specific databases

EuPathDBiFungiDB:YPR032W.
SGDiS000006236. SRO7.

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiQ12038.
KOiK08518.
OMAiHESGFIR.
OrthoDBiEOG092C096J.

Enzyme and pathway databases

BioCyciYEAST:G3O-34191-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12038.
PROiQ12038.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRO7_YEAST
AccessioniPrimary (citable) accession number: Q12038
Secondary accession number(s): D6W442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.