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Q12034

- SLF1_YEAST

UniProt

Q12034 - SLF1_YEAST

Protein

Protein SLF1

Gene

SLF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Regulates the copper-dependent mineralization of copper sulfide complexes on the cell surface in cells cultured in medium containing copper salts.

    GO - Molecular functioni

    1. RNA binding Source: SGD

    GO - Biological processi

    1. cellular copper ion homeostasis Source: SGD
    2. regulation of translation Source: SGD

    Keywords - Ligandi

    Copper, RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30034-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SLF1
    Gene namesi
    Name:SLF1
    Ordered Locus Names:YDR515W
    ORF Names:D9719.20
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR515w.
    SGDiS000002923. SLF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic stress granule Source: SGD
    2. polysome Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Protein SLF1PRO_0000207614Add
    BLAST

    Proteomic databases

    MaxQBiQ12034.
    PaxDbiQ12034.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12034.

    Interactioni

    Protein-protein interaction databases

    BioGridi32566. 533 interactions.
    DIPiDIP-2938N.
    IntActiQ12034. 5 interactions.
    MINTiMINT-574898.
    STRINGi4932.YDR515W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12034.
    SMRiQ12034. Positions 273-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini265 – 368104HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5193.
    GeneTreeiENSGT00530000067375.
    OMAiANDGFIP.
    OrthoDBiEOG7QNVZG.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR006630. Lupus_La_RNA-bd.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05383. La. 1 hit.
    [Graphical view]
    SMARTiSM00715. LA. 1 hit.
    [Graphical view]
    PROSITEiPS50961. HTH_LA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12034-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQNLNDNP KNTSSAAEDK KKQTSSLKLA PIPTTSPWKS SSPDSNTVIP    50
    VEELRDISKT AKPSKNGSGS IKLTSNTKWT PITPSVIISG SKDTNSKSGK 100
    NSKNSKTNKK MKKRGKYNND INKKDFNGQT NSTSEISNVS NLESKPLDAN 150
    AKVNIHSSSG ATANGNIKRI TNNNNSTNGR QSRNYQNRNG KTRYNNNSRH 200
    SQAANNAISF PNNYQARPEY IPNASHWLNN NSRNSYKQLS YFRQQQYYNN 250
    INYQQQLQTP YYYSMEPIFK SIESIKNQIE FYFSEENLKT DEFLRSKFKK 300
    ANDGFIPMSL IGKFYRMVNL SLGGDPNLIL ASMREVLQHK ETNHLEIALG 350
    SIEGAQKNMA DDFNPLENYF IRRENWAEYA MESNFDENDD ETEKYNIEKL 400
    LGPNDLDNYS YMGYPNFFPS NENGKKSQSY DQGEISRQFE QNLQIND 447
    Length:447
    Mass (Da):50,943
    Last modified:November 1, 1996 - v1
    Checksum:i7D09BD00E141555B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti118 – 1181N → S in AAT92958. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30375 Genomic DNA. Translation: AAB04684.1.
    U33057 Genomic DNA. Translation: AAB64956.1.
    AY692939 Genomic DNA. Translation: AAT92958.1.
    BK006938 Genomic DNA. Translation: DAA12346.1.
    PIRiS59742.
    RefSeqiNP_010803.3. NM_001180823.3.

    Genome annotation databases

    EnsemblFungiiYDR515W; YDR515W; YDR515W.
    GeneIDi852127.
    KEGGisce:YDR515W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30375 Genomic DNA. Translation: AAB04684.1 .
    U33057 Genomic DNA. Translation: AAB64956.1 .
    AY692939 Genomic DNA. Translation: AAT92958.1 .
    BK006938 Genomic DNA. Translation: DAA12346.1 .
    PIRi S59742.
    RefSeqi NP_010803.3. NM_001180823.3.

    3D structure databases

    ProteinModelPortali Q12034.
    SMRi Q12034. Positions 273-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32566. 533 interactions.
    DIPi DIP-2938N.
    IntActi Q12034. 5 interactions.
    MINTi MINT-574898.
    STRINGi 4932.YDR515W.

    Proteomic databases

    MaxQBi Q12034.
    PaxDbi Q12034.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR515W ; YDR515W ; YDR515W .
    GeneIDi 852127.
    KEGGi sce:YDR515W.

    Organism-specific databases

    CYGDi YDR515w.
    SGDi S000002923. SLF1.

    Phylogenomic databases

    eggNOGi COG5193.
    GeneTreei ENSGT00530000067375.
    OMAi ANDGFIP.
    OrthoDBi EOG7QNVZG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30034-MONOMER.

    Miscellaneous databases

    NextBioi 970519.

    Gene expression databases

    Genevestigatori Q12034.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR006630. Lupus_La_RNA-bd.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05383. La. 1 hit.
    [Graphical view ]
    SMARTi SM00715. LA. 1 hit.
    [Graphical view ]
    PROSITEi PS50961. HTH_LA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae."
      Yu W., Farrell R.A., Stillman D.J., Winge D.R.
      Mol. Cell. Biol. 16:2464-2472(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSLF1_YEAST
    AccessioniPrimary (citable) accession number: Q12034
    Secondary accession number(s): D6VTD6, E9P8Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 861 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3