Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q12034 (SLF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SLF1
Gene names
Name:SLF1
Ordered Locus Names:YDR515W
ORF Names:D9719.20
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the copper-dependent mineralization of copper sulfide complexes on the cell surface in cells cultured in medium containing copper salts.

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Protein SLF1
PRO_0000207614

Regions

Domain265 – 368104HTH La-type RNA-binding

Amino acid modifications

Modified residue401Phosphoserine Ref.7
Modified residue421Phosphoserine Ref.6 Ref.7
Modified residue451Phosphoserine Ref.7
Modified residue4271Phosphoserine Ref.7

Experimental info

Sequence conflict1181N → S in AAT92958. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q12034 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7D09BD00E141555B

FASTA44750,943
        10         20         30         40         50         60 
MSSQNLNDNP KNTSSAAEDK KKQTSSLKLA PIPTTSPWKS SSPDSNTVIP VEELRDISKT 

        70         80         90        100        110        120 
AKPSKNGSGS IKLTSNTKWT PITPSVIISG SKDTNSKSGK NSKNSKTNKK MKKRGKYNND 

       130        140        150        160        170        180 
INKKDFNGQT NSTSEISNVS NLESKPLDAN AKVNIHSSSG ATANGNIKRI TNNNNSTNGR 

       190        200        210        220        230        240 
QSRNYQNRNG KTRYNNNSRH SQAANNAISF PNNYQARPEY IPNASHWLNN NSRNSYKQLS 

       250        260        270        280        290        300 
YFRQQQYYNN INYQQQLQTP YYYSMEPIFK SIESIKNQIE FYFSEENLKT DEFLRSKFKK 

       310        320        330        340        350        360 
ANDGFIPMSL IGKFYRMVNL SLGGDPNLIL ASMREVLQHK ETNHLEIALG SIEGAQKNMA 

       370        380        390        400        410        420 
DDFNPLENYF IRRENWAEYA MESNFDENDD ETEKYNIEKL LGPNDLDNYS YMGYPNFFPS 

       430        440 
NENGKKSQSY DQGEISRQFE QNLQIND

« Hide

References

« Hide 'large scale' references
[1]"Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae."
Yu W., Farrell R.A., Stillman D.J., Winge D.R.
Mol. Cell. Biol. 16:2464-2472(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, MASS SPECTROMETRY.
Strain: YAL6B.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-42; SER-45 AND SER-427, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U30375 Genomic DNA. Translation: AAB04684.1.
U33057 Genomic DNA. Translation: AAB64956.1.
AY692939 Genomic DNA. Translation: AAT92958.1.
BK006938 Genomic DNA. Translation: DAA12346.1.
PIRS59742.
RefSeqNP_010803.3. NM_001180823.3.

3D structure databases

ProteinModelPortalQ12034.
SMRQ12034. Positions 272-382.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2938N.
IntActQ12034. 5 interactions.
MINTMINT-574898.
STRING4932.YDR515W.

Proteomic databases

PaxDbQ12034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR515W; YDR515W; YDR515W.
GeneID852127.
KEGGsce:YDR515W.
sce:YDR519W.

Organism-specific databases

CYGDYDR515w.
SGDS000002923. SLF1.

Phylogenomic databases

eggNOGCOG5193.
GeneTreeENSGT00530000067375.
KOK09569.
OrthoDBEOG46MFST.

Gene expression databases

GenevestigatorQ12034.
GermOnlineYDR515W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
[Graphical view]
SMARTSM00715. LA. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio970519.

Entry information

Entry nameSLF1_YEAST
AccessionPrimary (citable) accession number: Q12034
Secondary accession number(s): D6VTD6, E9P8Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents