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Q12034

- SLF1_YEAST

UniProt

Q12034 - SLF1_YEAST

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Protein
Protein SLF1
Gene
SLF1, YDR515W, D9719.20
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the copper-dependent mineralization of copper sulfide complexes on the cell surface in cells cultured in medium containing copper salts.

GO - Molecular functioni

  1. RNA binding Source: SGD

GO - Biological processi

  1. cellular copper ion homeostasis Source: SGD
  2. regulation of translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

Copper, RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLF1
Gene namesi
Name:SLF1
Ordered Locus Names:YDR515W
ORF Names:D9719.20
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR515w.
SGDiS000002923. SLF1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic stress granule Source: SGD
  2. polysome Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Protein SLF1
PRO_0000207614Add
BLAST

Proteomic databases

MaxQBiQ12034.
PaxDbiQ12034.

Expressioni

Gene expression databases

GenevestigatoriQ12034.

Interactioni

Protein-protein interaction databases

BioGridi32566. 532 interactions.
DIPiDIP-2938N.
IntActiQ12034. 5 interactions.
MINTiMINT-574898.
STRINGi4932.YDR515W.

Structurei

3D structure databases

ProteinModelPortaliQ12034.
SMRiQ12034. Positions 273-351.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 368104HTH La-type RNA-binding
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5193.
GeneTreeiENSGT00530000067375.
OMAiANDGFIP.
OrthoDBiEOG7QNVZG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00715. LA. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12034-1 [UniParc]FASTAAdd to Basket

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MSSQNLNDNP KNTSSAAEDK KKQTSSLKLA PIPTTSPWKS SSPDSNTVIP    50
VEELRDISKT AKPSKNGSGS IKLTSNTKWT PITPSVIISG SKDTNSKSGK 100
NSKNSKTNKK MKKRGKYNND INKKDFNGQT NSTSEISNVS NLESKPLDAN 150
AKVNIHSSSG ATANGNIKRI TNNNNSTNGR QSRNYQNRNG KTRYNNNSRH 200
SQAANNAISF PNNYQARPEY IPNASHWLNN NSRNSYKQLS YFRQQQYYNN 250
INYQQQLQTP YYYSMEPIFK SIESIKNQIE FYFSEENLKT DEFLRSKFKK 300
ANDGFIPMSL IGKFYRMVNL SLGGDPNLIL ASMREVLQHK ETNHLEIALG 350
SIEGAQKNMA DDFNPLENYF IRRENWAEYA MESNFDENDD ETEKYNIEKL 400
LGPNDLDNYS YMGYPNFFPS NENGKKSQSY DQGEISRQFE QNLQIND 447
Length:447
Mass (Da):50,943
Last modified:November 1, 1996 - v1
Checksum:i7D09BD00E141555B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181N → S in AAT92958. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30375 Genomic DNA. Translation: AAB04684.1.
U33057 Genomic DNA. Translation: AAB64956.1.
AY692939 Genomic DNA. Translation: AAT92958.1.
BK006938 Genomic DNA. Translation: DAA12346.1.
PIRiS59742.
RefSeqiNP_010803.3. NM_001180823.3.

Genome annotation databases

EnsemblFungiiYDR515W; YDR515W; YDR515W.
GeneIDi852127.
KEGGisce:YDR515W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30375 Genomic DNA. Translation: AAB04684.1 .
U33057 Genomic DNA. Translation: AAB64956.1 .
AY692939 Genomic DNA. Translation: AAT92958.1 .
BK006938 Genomic DNA. Translation: DAA12346.1 .
PIRi S59742.
RefSeqi NP_010803.3. NM_001180823.3.

3D structure databases

ProteinModelPortali Q12034.
SMRi Q12034. Positions 273-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32566. 532 interactions.
DIPi DIP-2938N.
IntActi Q12034. 5 interactions.
MINTi MINT-574898.
STRINGi 4932.YDR515W.

Proteomic databases

MaxQBi Q12034.
PaxDbi Q12034.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR515W ; YDR515W ; YDR515W .
GeneIDi 852127.
KEGGi sce:YDR515W.

Organism-specific databases

CYGDi YDR515w.
SGDi S000002923. SLF1.

Phylogenomic databases

eggNOGi COG5193.
GeneTreei ENSGT00530000067375.
OMAi ANDGFIP.
OrthoDBi EOG7QNVZG.

Enzyme and pathway databases

BioCyci YEAST:G3O-30034-MONOMER.

Miscellaneous databases

NextBioi 970519.

Gene expression databases

Genevestigatori Q12034.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05383. La. 1 hit.
[Graphical view ]
SMARTi SM00715. LA. 1 hit.
[Graphical view ]
PROSITEi PS50961. HTH_LA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae."
    Yu W., Farrell R.A., Stillman D.J., Winge D.R.
    Mol. Cell. Biol. 16:2464-2472(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSLF1_YEAST
AccessioniPrimary (citable) accession number: Q12034
Secondary accession number(s): D6VTD6, E9P8Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

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