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Q12029 (FSF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mitochondrial transport protein FSF1
Alternative name(s):
Fungal sideroflexin-1
Gene names
Name:FSF1
Ordered Locus Names:YOR271C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transports citrate. Potential iron transporter By similarity.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity Ref.4 Ref.6.

Miscellaneous

Present with 9290 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the sideroflexin family.

Ontologies

Keywords
   Biological processIon transport
Iron transport
Transport
   Cellular componentMembrane
Mitochondrion
   DomainTransmembrane
Transmembrane helix
   LigandIron
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processiron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 327326Probable mitochondrial transport protein FSF1
PRO_0000237642

Regions

Transmembrane98 – 11821Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane272 – 29221Helical; Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q12029 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FD175626E63B8619

FASTA32735,414
        10         20         30         40         50         60 
MASSVPGPID LPESRYDLST YWGRIRHCAE ISDPTMLLTT EKDLAHAREI ISAYRHGELK 

        70         80         90        100        110        120 
ETTPEFWRAK KQLDSTVHPD TGKTVLLPFR MSSNVLSNLV VTVGMLTPGL GTAGTVFWQW 

       130        140        150        160        170        180 
ANQSLNVAVN SANANKSHPM STSQLLTNYA AAVTASCGVA LGLNNLVPRL KNISPHSKLI 

       190        200        210        220        230        240 
LGRLVPFAAV VSAGIVNVFL MRGNEIRKGI SVFDSNGDEV GKSKKAAFMA VGETALSRVI 

       250        260        270        280        290        300 
NATPTMVIPP LILVRLQRGV LKGKSLGVQT LANLGLISVT MFSALPFALG IFPQRQAIHL 

       310        320 
NKLEPELHGK KDKDGKPIEK VYFNRGI 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae."
Cheret G., Bernardi A., Sor F.J.
Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family."
Miotto G., Tessaro S., Rotta G.A., Bonatto D.
Fungal Genet. Biol. 44:740-753(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE NAME.
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89633 Genomic DNA. Translation: CAA61777.1.
Z75179 Genomic DNA. Translation: CAA99495.1.
BK006948 Genomic DNA. Translation: DAA11037.1.
PIRS67168.
RefSeqNP_014914.1. NM_001183690.1.

3D structure databases

ProteinModelPortalQ12029.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34660. 23 interactions.
DIPDIP-3828N.
IntActQ12029. 21 interactions.
MINTMINT-504219.
STRING4932.YOR271C.

Protein family/group databases

TCDB2.A.54.1.4. the mitochondrial tricarboxylate carrier (mtc) family.

Proteomic databases

MaxQBQ12029.
PaxDbQ12029.
PeptideAtlasQ12029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR271C; YOR271C; YOR271C.
GeneID854445.
KEGGsce:YOR271C.

Organism-specific databases

CYGDYOR271c.
SGDS000005797. FSF1.

Phylogenomic databases

eggNOGNOG283056.
GeneTreeENSGT00390000002026.
HOGENOMHOG000203440.
OMAWGRVRHS.
OrthoDBEOG74J9JJ.

Enzyme and pathway databases

BioCycYEAST:G3O-33761-MONOMER.

Gene expression databases

GenevestigatorQ12029.

Family and domain databases

InterProIPR004686. Mtc.
[Graphical view]
PANTHERPTHR11153. PTHR11153. 1 hit.
PfamPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00798. mtc. 1 hit.
ProtoNetSearch...

Other

NextBio976697.
PROQ12029.

Entry information

Entry nameFSF1_YEAST
AccessionPrimary (citable) accession number: Q12029
Secondary accession number(s): D6W2X1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families