Q12029 (FSF1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable mitochondrial transport protein FSF1

Alternative name(s):
Fungal sideroflexin-1

Gene names

Name:	FSF1
Ordered Locus Names:	YOR271C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transports citrate. Potential iron transporter By similarity.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity Ref.4 Ref.6.
Miscellaneous	Present with 9290 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the sideroflexin family.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	Iron
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay Ref.4Ref.6. Source: SGD
Molecular_function	cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Probable mitochondrial transport protein FSF1		PRO_0000237642
Regions
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	272 – 292	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12029 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FD175626E63B8619	FASTA	327	35,414
	10 20 30 40 50 60 MASSVPGPID LPESRYDLST YWGRIRHCAE ISDPTMLLTT EKDLAHAREI ISAYRHGELK 70 80 90 100 110 120 ETTPEFWRAK KQLDSTVHPD TGKTVLLPFR MSSNVLSNLV VTVGMLTPGL GTAGTVFWQW 130 140 150 160 170 180 ANQSLNVAVN SANANKSHPM STSQLLTNYA AAVTASCGVA LGLNNLVPRL KNISPHSKLI 190 200 210 220 230 240 LGRLVPFAAV VSAGIVNVFL MRGNEIRKGI SVFDSNGDEV GKSKKAAFMA VGETALSRVI 250 260 270 280 290 300 NATPTMVIPP LILVRLQRGV LKGKSLGVQT LANLGLISVT MFSALPFALG IFPQRQAIHL 310 320 NKLEPELHGK KDKDGKPIEK VYFNRGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae." Cheret G., Bernardi A., Sor F.J. Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family." Miotto G., Tessaro S., Rotta G.A., Bonatto D. Fungal Genet. Biol. 44:740-753(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89633 Genomic DNA. Translation: CAA61777.1. Z75179 Genomic DNA. Translation: CAA99495.1. BK006948 Genomic DNA. Translation: DAA11037.1.
PIR	S67168.
RefSeq	NP_014914.1. NM_001183690.1.
3D structure databases
ProteinModelPortal	Q12029.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3828N.
IntAct	Q12029. 21 interactions.
MINT	MINT-504219.
STRING	4932.YOR271C.
Proteomic databases
PaxDb	Q12029.
PeptideAtlas	Q12029.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR271C; YOR271C; YOR271C.
GeneID	854445.
KEGG	sce:YOR271C.
Organism-specific databases
CYGD	YOR271c.
SGD	S000005797. FSF1.
Phylogenomic databases
eggNOG	NOG283056.
GeneTree	ENSGT00390000002026.
HOGENOM	HOG000203440.
OMA	YKHGTLP.
OrthoDB	EOG4MD185.
Gene expression databases
Genevestigator	Q12029.
GermOnline	YOR271C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004686. Mtc. [Graphical view]
PANTHER	PTHR11153. PTHR11153. 1 hit.
Pfam	PF03820. Mtc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00798. mtc. 1 hit.
ProtoNet	Search...
Other
NextBio	976697.

Entry information

Entry name

FSF1_YEAST

Accession

Primary (citable) accession number: Q12029
Secondary accession number(s): D6W2X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program