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Q12029

- FSF1_YEAST

UniProt

Q12029 - FSF1_YEAST

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Protein
Probable mitochondrial transport protein FSF1
Gene
FSF1, YOR271C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transports citrate. Potential iron transporter By similarity.

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-33761-MONOMER.

Protein family/group databases

TCDBi2.A.54.1.4. the mitochondrial tricarboxylate carrier (mtc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial transport protein FSF1
Alternative name(s):
Fungal sideroflexin-1
Gene namesi
Name:FSF1
Ordered Locus Names:YOR271C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR271c.
SGDiS000005797. FSF1.

Subcellular locationi

Mitochondrion membrane; Multi-pass membrane protein By similarity 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 327326Probable mitochondrial transport protein FSF1
PRO_0000237642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12029.
PaxDbiQ12029.
PeptideAtlasiQ12029.

Expressioni

Gene expression databases

GenevestigatoriQ12029.

Interactioni

Protein-protein interaction databases

BioGridi34660. 23 interactions.
DIPiDIP-3828N.
IntActiQ12029. 21 interactions.
MINTiMINT-504219.
STRINGi4932.YOR271C.

Structurei

3D structure databases

ProteinModelPortaliQ12029.

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283056.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
OMAiWGRVRHS.
OrthoDBiEOG74J9JJ.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12029-1 [UniParc]FASTAAdd to Basket

« Hide

MASSVPGPID LPESRYDLST YWGRIRHCAE ISDPTMLLTT EKDLAHAREI    50
ISAYRHGELK ETTPEFWRAK KQLDSTVHPD TGKTVLLPFR MSSNVLSNLV 100
VTVGMLTPGL GTAGTVFWQW ANQSLNVAVN SANANKSHPM STSQLLTNYA 150
AAVTASCGVA LGLNNLVPRL KNISPHSKLI LGRLVPFAAV VSAGIVNVFL 200
MRGNEIRKGI SVFDSNGDEV GKSKKAAFMA VGETALSRVI NATPTMVIPP 250
LILVRLQRGV LKGKSLGVQT LANLGLISVT MFSALPFALG IFPQRQAIHL 300
NKLEPELHGK KDKDGKPIEK VYFNRGI 327
Length:327
Mass (Da):35,414
Last modified:November 1, 1996 - v1
Checksum:iFD175626E63B8619
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89633 Genomic DNA. Translation: CAA61777.1.
Z75179 Genomic DNA. Translation: CAA99495.1.
BK006948 Genomic DNA. Translation: DAA11037.1.
PIRiS67168.
RefSeqiNP_014914.1. NM_001183690.1.

Genome annotation databases

EnsemblFungiiYOR271C; YOR271C; YOR271C.
GeneIDi854445.
KEGGisce:YOR271C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89633 Genomic DNA. Translation: CAA61777.1 .
Z75179 Genomic DNA. Translation: CAA99495.1 .
BK006948 Genomic DNA. Translation: DAA11037.1 .
PIRi S67168.
RefSeqi NP_014914.1. NM_001183690.1.

3D structure databases

ProteinModelPortali Q12029.
ModBasei Search...

Protein-protein interaction databases

BioGridi 34660. 23 interactions.
DIPi DIP-3828N.
IntActi Q12029. 21 interactions.
MINTi MINT-504219.
STRINGi 4932.YOR271C.

Protein family/group databases

TCDBi 2.A.54.1.4. the mitochondrial tricarboxylate carrier (mtc) family.

Proteomic databases

MaxQBi Q12029.
PaxDbi Q12029.
PeptideAtlasi Q12029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR271C ; YOR271C ; YOR271C .
GeneIDi 854445.
KEGGi sce:YOR271C.

Organism-specific databases

CYGDi YOR271c.
SGDi S000005797. FSF1.

Phylogenomic databases

eggNOGi NOG283056.
GeneTreei ENSGT00390000002026.
HOGENOMi HOG000203440.
OMAi WGRVRHS.
OrthoDBi EOG74J9JJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-33761-MONOMER.

Miscellaneous databases

NextBioi 976697.
PROi Q12029.

Gene expression databases

Genevestigatori Q12029.

Family and domain databases

InterProi IPR004686. Mtc.
[Graphical view ]
PANTHERi PTHR11153. PTHR11153. 1 hit.
Pfami PF03820. Mtc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00798. mtc. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae."
    Cheret G., Bernardi A., Sor F.J.
    Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family."
    Miotto G., Tessaro S., Rotta G.A., Bonatto D.
    Fungal Genet. Biol. 44:740-753(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFSF1_YEAST
AccessioniPrimary (citable) accession number: Q12029
Secondary accession number(s): D6W2X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9290 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

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