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Q12029

- FSF1_YEAST

UniProt

Q12029 - FSF1_YEAST

Protein

Probable mitochondrial transport protein FSF1

Gene

FSF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transports citrate. Potential iron transporter By similarity.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33761-MONOMER.

    Protein family/group databases

    TCDBi2.A.54.1.4. the mitochondrial tricarboxylate carrier (mtc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mitochondrial transport protein FSF1
    Alternative name(s):
    Fungal sideroflexin-1
    Gene namesi
    Name:FSF1
    Ordered Locus Names:YOR271C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR271c.
    SGDiS000005797. FSF1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 327326Probable mitochondrial transport protein FSF1PRO_0000237642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ12029.
    PaxDbiQ12029.
    PeptideAtlasiQ12029.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12029.

    Interactioni

    Protein-protein interaction databases

    BioGridi34660. 23 interactions.
    DIPiDIP-3828N.
    IntActiQ12029. 21 interactions.
    MINTiMINT-504219.
    STRINGi4932.YOR271C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12029.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sideroflexin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283056.
    GeneTreeiENSGT00390000002026.
    HOGENOMiHOG000203440.
    OMAiWGRVRHS.
    OrthoDBiEOG74J9JJ.

    Family and domain databases

    InterProiIPR004686. Mtc.
    [Graphical view]
    PANTHERiPTHR11153. PTHR11153. 1 hit.
    PfamiPF03820. Mtc. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00798. mtc. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12029-1 [UniParc]FASTAAdd to Basket

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    MASSVPGPID LPESRYDLST YWGRIRHCAE ISDPTMLLTT EKDLAHAREI    50
    ISAYRHGELK ETTPEFWRAK KQLDSTVHPD TGKTVLLPFR MSSNVLSNLV 100
    VTVGMLTPGL GTAGTVFWQW ANQSLNVAVN SANANKSHPM STSQLLTNYA 150
    AAVTASCGVA LGLNNLVPRL KNISPHSKLI LGRLVPFAAV VSAGIVNVFL 200
    MRGNEIRKGI SVFDSNGDEV GKSKKAAFMA VGETALSRVI NATPTMVIPP 250
    LILVRLQRGV LKGKSLGVQT LANLGLISVT MFSALPFALG IFPQRQAIHL 300
    NKLEPELHGK KDKDGKPIEK VYFNRGI 327
    Length:327
    Mass (Da):35,414
    Last modified:November 1, 1996 - v1
    Checksum:iFD175626E63B8619
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89633 Genomic DNA. Translation: CAA61777.1.
    Z75179 Genomic DNA. Translation: CAA99495.1.
    BK006948 Genomic DNA. Translation: DAA11037.1.
    PIRiS67168.
    RefSeqiNP_014914.1. NM_001183690.1.

    Genome annotation databases

    EnsemblFungiiYOR271C; YOR271C; YOR271C.
    GeneIDi854445.
    KEGGisce:YOR271C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89633 Genomic DNA. Translation: CAA61777.1 .
    Z75179 Genomic DNA. Translation: CAA99495.1 .
    BK006948 Genomic DNA. Translation: DAA11037.1 .
    PIRi S67168.
    RefSeqi NP_014914.1. NM_001183690.1.

    3D structure databases

    ProteinModelPortali Q12029.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34660. 23 interactions.
    DIPi DIP-3828N.
    IntActi Q12029. 21 interactions.
    MINTi MINT-504219.
    STRINGi 4932.YOR271C.

    Protein family/group databases

    TCDBi 2.A.54.1.4. the mitochondrial tricarboxylate carrier (mtc) family.

    Proteomic databases

    MaxQBi Q12029.
    PaxDbi Q12029.
    PeptideAtlasi Q12029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR271C ; YOR271C ; YOR271C .
    GeneIDi 854445.
    KEGGi sce:YOR271C.

    Organism-specific databases

    CYGDi YOR271c.
    SGDi S000005797. FSF1.

    Phylogenomic databases

    eggNOGi NOG283056.
    GeneTreei ENSGT00390000002026.
    HOGENOMi HOG000203440.
    OMAi WGRVRHS.
    OrthoDBi EOG74J9JJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33761-MONOMER.

    Miscellaneous databases

    NextBioi 976697.
    PROi Q12029.

    Gene expression databases

    Genevestigatori Q12029.

    Family and domain databases

    InterProi IPR004686. Mtc.
    [Graphical view ]
    PANTHERi PTHR11153. PTHR11153. 1 hit.
    Pfami PF03820. Mtc. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00798. mtc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae."
      Cheret G., Bernardi A., Sor F.J.
      Yeast 12:1059-1064(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. "In silico analyses of Fsf1 sequences, a new group of fungal proteins orthologous to the metazoan sideroblastic anemia-related sideroflexin family."
      Miotto G., Tessaro S., Rotta G.A., Bonatto D.
      Fungal Genet. Biol. 44:740-753(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFSF1_YEAST
    AccessioniPrimary (citable) accession number: Q12029
    Secondary accession number(s): D6W2X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 9290 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3