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Protein

AP-1 complex subunit gamma-1

Gene

APL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin.1 Publication

Miscellaneous

Present with 4850 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • clathrin binding Source: SGD

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • intracellular protein transport Source: InterPro
  • vesicle-mediated transport Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34188-MONOMER
ReactomeiR-SCE-432720 Lysosome Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-1
Alternative name(s):
Clathrin assembly protein complex 1 gamma large chain
Clathrin assembly protein large gamma chain
Gamma-adaptin
Gene namesi
Name:APL4
Ordered Locus Names:YPR029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR029C
SGDiS000006233 APL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937641 – 832AP-1 complex subunit gamma-1Add BLAST832

Proteomic databases

MaxQBiQ12028
PaxDbiQ12028
PRIDEiQ12028

PTM databases

iPTMnetiQ12028

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin binding Source: SGD

Protein-protein interaction databases

BioGridi36207, 177 interactors
DIPiDIP-3913N
IntActiQ12028, 30 interactors
MINTiQ12028
STRINGi4932.YPR029C

Structurei

3D structure databases

ProteinModelPortaliQ12028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini733 – 832GAEAdd BLAST100

Phylogenomic databases

GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
InParanoidiQ12028
KOiK12391
OMAiWHVDTML
OrthoDBiEOG092C0BGI

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit

Sequencei

Sequence statusi: Complete.

Q12028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSLRSFIK DVRGAKTLAD ERAIITKQSA KIRTKLRDDH LPHEKRRVNI
60 70 80 90 100
QKLLYLYILG EKTHFGQVES INLIASDDFV DKRLGYLAAT LLLDESEDLL
110 120 130 140 150
TLLTNMLNND LHHPNKYAVS LALTSLGFLS SPELARDLYP DVENIIKNSR
160 170 180 190 200
DPFLLKKALQ CAAKLIFKDV SLLEIFNIED ITKILSSHSI CTHGVLLGVT
210 220 230 240 250
KIIQSILLIG LNRKKDEDED EDGIDYSNDI LSPLSLLLRD FFIRLENMNS
260 270 280 290 300
KNIEPGYDVQ GICDPFLQCE IIYTLKLYFQ VGELLNSNNV LDYKDNFCDL
310 320 330 340 350
LTRIATNTDS TKNSGQAILY ETVKTIFSLD LNQPLRVLGI NILAKFLAGK
360 370 380 390 400
DNNTKYVSLN TLLKVVPQEP TAVQRHRKFI SHCLQDTDVS IRMRALELSF
410 420 430 440 450
AILDDSNLVE LVNELMKFLA KQDEDSKDLI IYTIDHLIDT FDTRVVKDES
460 470 480 490 500
WKLDVFFNIL KLVGSFINYE KINDILIIIN NTSQLSDKSE FLRKMLTISL
510 520 530 540 550
NGTSAEISEE NIGWQLVLIW CIGEYGDLVL NEGNKNGADI INESSITDYL
560 570 580 590 600
LTLQELYTAT NLKIINYILT AALKLSVRFH DAKNIEKLRQ LILSYTDSTD
610 620 630 640 650
LSLQMKSNQY EIFFNQSISV KKIILETMPK FEKITEEQDN GKALSKNLIS
660 670 680 690 700
NEPVDLLSDL LGEDSKAESK ASTGDNVKPI DILEEIFGEK NDIAQVPKNA
710 720 730 740 750
NKEESINHSS AVEANSGVTL PLDANKIYDS SSLNVYASLL SANSGLAHLD
760 770 780 790 800
LYFQAKSLIS DLKTFCAVPK AQKLTLGQLY PSSTINASQI CKQSLKISGS
810 820 830
GKLKLRVKLD FHLNGSSSIT NEQFDHKFDE TL
Length:832
Mass (Da):93,624
Last modified:November 1, 1996 - v1
Checksum:iABB619E9DC4F565C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95025.1
Z49274 Genomic DNA Translation: CAA89283.1
BK006949 Genomic DNA Translation: DAA11455.1
PIRiS54503
RefSeqiNP_015354.1, NM_001184126.1

Genome annotation databases

EnsemblFungiiYPR029C; YPR029C; YPR029C
GeneIDi856141
KEGGisce:YPR029C

Similar proteinsi

Entry informationi

Entry nameiAP1G1_YEAST
AccessioniPrimary (citable) accession number: Q12028
Secondary accession number(s): D6W439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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