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Protein

Radiation-sensitive protein 28

Gene

RAD28

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcription-coupled repair nucleotide excision repair (NER) of UV-induced DNA lesions.2 Publications

GO - Biological processi

  • DNA repair Source: SGD

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-29645-MONOMER
ReactomeiR-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
Radiation-sensitive protein 28
Gene namesi
Name:RAD28
Ordered Locus Names:YDR030C
ORF Names:YD9813.08c
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR030C
SGDiS000002437 RAD28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686971 – 506Radiation-sensitive protein 28Add BLAST506

Proteomic databases

PaxDbiQ12021
PRIDEiQ12021

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DUN1P390092EBI-29718,EBI-6194

Protein-protein interaction databases

BioGridi32079, 34 interactors
DIPiDIP-5177N
IntActiQ12021, 18 interactors
STRINGi4932.YDR030C

Structurei

3D structure databases

ProteinModelPortaliQ12021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 94WD 1Add BLAST40
Repeati193 – 233WD 2Add BLAST41
Repeati285 – 325WD 3Add BLAST41
Repeati357 – 396WD 4Add BLAST40
Repeati404 – 451WD 5Add BLAST48

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000009065
HOGENOMiHOG000065962
InParanoidiQ12021
KOiK10570
OMAiDNGMFFT
OrthoDBiEOG092C1TMB

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q12021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFLEFRVG NISLNEFYRR TIQSEFERIL EDPLSNMKNY RFSKQSNYST
60 70 80 90 100
KEKTPLSIGV NCLDIDDTGQ VLLGGGDDGS LSIWGLDESL HRNDEGEQEL
110 120 130 140 150
INKRLNYIKR QPHQSDDEPA QIMGYKNKRT RINDNNTMRL VHSFQTQRNK
160 170 180 190 200
YRMYRQSSAA VPVQRSHISN KTDSPIGFSE TLSETDSEAS ISHHKYGITT
210 220 230 240 250
LKWYKADNGM FFTGSNDKTV KIWDTNRFEA VQDINLGYKI NQIDNNVVDD
260 270 280 290 300
SSLLVVASED YYPRLIDLRT MNSGVTALGM GNQTRMQSEI LCCKFNPVRE
310 320 330 340 350
QIIACGDMEG GVKLWDLRMR NRLYSELKRN KNRFKTINND DNDDQSDVYF
360 370 380 390 400
SSNQSKAHLR CCSDIVWNSE GSELCSVGMD GKLNVWRPFT EILQPEGLAS
410 420 430 440 450
YSQLGTQDLS RIKYKKRVSR RLLWFDKFLL CITDNGEVEI YNTEEKKLWN
460 470 480 490 500
KLEYPMVNQV KKNQASHCQF SSMIVQTNIM NSVGLKLFFG TNNNTVSDGG

SIFECS
Length:506
Mass (Da):58,230
Last modified:November 1, 1996 - v1
Checksum:i3517F97D9C1F4874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47814 Genomic DNA Translation: CAA87809.1
Z74326 Genomic DNA Translation: CAA98852.1
BK006938 Genomic DNA Translation: DAA11874.1
PIRiS50937
RefSeqiNP_010313.3, NM_001180338.3

Genome annotation databases

EnsemblFungiiYDR030C; YDR030C; YDR030C
GeneIDi851594
KEGGisce:YDR030C

Similar proteinsi

Entry informationi

Entry nameiRAD28_YEAST
AccessioniPrimary (citable) accession number: Q12021
Secondary accession number(s): D6VS14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health