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Q12019

- MDN1_YEAST

UniProt

Q12019 - MDN1_YEAST

Protein

Midasin

Gene

MDN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. Mediates ATP-dependent remodeling of the pre-ribosome just prior to export to allow maturation of 60S subunits into export-competent particles. Removes the ribosome biogenesis factor RSA4 from pre-60S ribosomal subunits in the nucleoplasm to drive nuclear export of the subunit. Involved in 3' processing of the 5.8S rRNA.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi315 – 3228ATPSequence Analysis
    Nucleotide bindingi653 – 6608ATPSequence Analysis
    Nucleotide bindingi1083 – 10908ATPSequence Analysis
    Nucleotide bindingi1368 – 13758ATPSequence Analysis
    Nucleotide bindingi1747 – 17548ATPSequence Analysis
    Nucleotide bindingi2054 – 20618ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. protein complex assembly Source: InterPro
    3. ribosomal large subunit assembly Source: SGD
    4. rRNA processing Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Midasin
    Alternative name(s):
    MIDAS-containing protein
    Ribosome export/assembly protein 1
    Gene namesi
    Name:MDN1
    Synonyms:REA1
    Ordered Locus Names:YLR106C
    ORF Names:L2901, L8004.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR106c.
    SGDiS000004096. MDN1.

    Subcellular locationi

    Nucleus 3 Publications

    GO - Cellular componenti

    1. nucleoplasm Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 49104910MidasinPRO_0000096337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1026 – 10261Phosphothreonine1 Publication
    Modified residuei2971 – 29711Phosphoserine2 Publications
    Modified residuei4353 – 43531Phosphoserine1 Publication
    Modified residuei4388 – 43881Phosphothreonine1 Publication
    Modified residuei4555 – 45551Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12019.
    PaxDbiQ12019.
    PeptideAtlasiQ12019.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12019.

    Interactioni

    Subunit structurei

    Associates with pre-60S ribosomes in the nucleoplasm. Interacts with RSA4 and YTM1.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RSA4P253826EBI-10633,EBI-21980

    Protein-protein interaction databases

    BioGridi31379. 63 interactions.
    DIPiDIP-6285N.
    IntActiQ12019. 39 interactions.
    MINTiMINT-613312.
    STRINGi4932.YLR106C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12019.
    SMRiQ12019. Positions 649-680, 816-1234, 1364-1394, 1740-1837, 2048-2081.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4704 – 4899196VWFAPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi768 – 7714Poly-Lys
    Compositional biasi2904 – 29074Poly-Leu
    Compositional biasi4136 – 41394Poly-Glu

    Sequence similaritiesi

    Belongs to the midasin family.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5271.
    GeneTreeiENSGT00550000074802.
    HOGENOMiHOG000164494.
    KOiK14572.
    OMAiRIFLTMD.
    OrthoDBiEOG7JMGNQ.

    Family and domain databases

    Gene3Di3.40.50.300. 12 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR012099. Midasin.
    IPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF07728. AAA_5. 8 hits.
    [Graphical view]
    PIRSFiPIRSF010340. Midasin. 1 hit.
    SMARTiSM00382. AAA. 6 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 9 hits.
    SSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12019-1 [UniParc]FASTAAdd to Basket

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    MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG     50
    TILHSRSITG HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP 100
    VAMPLIEDYL DKENDHFITI LQNPSTQKDS DMFKILLAYY RLLYHNKEVF 150
    ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL KVLSLYLDMG EKTLNDMLDT 200
    YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV PECFTIEKKS 250
    SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ 300
    LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK 350
    LLIGTYTSGD KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS 400
    LLEKRELTIP SRGETVKAAN GFQLISTVRI NEDHQKDSSN KIYNLNMIGM 450
    RIWNVIELEE PSEEDLTHIL AQKFPILTNL IPKLIDSYKN VKSIYMNTKF 500
    ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI QSSVYDSIFS 550
    EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD 600
    SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL 650
    LVGETGTGKT TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV 700
    AVPIQENFET LFNATFSLKK NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM 750
    AQSILKITNT ENENENAKKK KRRLNTHEKK LLLDKWADFN DSVKKFEAQS 800
    SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE SISDLLTEPD 850
    SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY 900
    VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV 950
    DGSNQKPHFS IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS 1000
    EAILKPVIEK FTLGRLKNVK SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ 1050
    EQAHYIITPF VEKNMMNLVR ATSGKRFPVL IQGPTSSGKT SMIKYLADIT 1100
    GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA LRKGYWIVLD 1150
    ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY 1200
    GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR 1250
    QLSIERSASR LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC 1300
    RTPQEKVTVK KTLEKVMKVK LDMDQYYASL EDKSLEAIGS VTWTKGMRRL 1350
    SVLVSSCLKN KEPVLLVGET GCGKTTICQL LAQFMGRELI TLNAHQNTET 1400
    GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE LLQLYSKSDN 1450
    KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS 1500
    VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL 1550
    SPALRNRFTE IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK 1600
    KLGGGNATSG VISLRDILAW VEFINKVFPK IQNKSTALIQ GASMVFIDAL 1650
    GTNNTAYLAE NENDLKSLRT ECIIQLLKLC GDDLELQQIE TNEIIVTQDE 1700
    LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH KPILLEGSPG 1750
    VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA 1800
    PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH 1850
    PNFLVFAAQN PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY 1900
    PSIEPDIIAK MIKLMSTLED QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN 1950
    QYSICEDVDV FDFVDIIVKQ RFRTISDKNK AQLLIEDIFG KFSTKENFFK 2000
    LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV LKAINNNWPL 2050
    VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR 2100
    QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF 2150
    QDFRNRFNRF FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV 2200
    KAVEKGHWLI LDNANLCSPS VLDRLNSLLE IDGSLLINEC SQEDGQPRVL 2250
    KPHPNFRLFL TMDPKYGELS RAMRNRGVEI YIDELHSRST AFDRLTLGFE 2300
    LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC IFAQVHDILL 2350
    LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT 2400
    FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV 2450
    SKYSDKIKSP ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS 2500
    AAAFNGRHLK NIPRIPIFCI LYNILTVMSE NLKTESLFCG SNQYQYYWDL 2550
    LVIVIAALET AVTKDEARLR VYKELIDSWI ASVKSKSDIE ITPFLNINLE 2600
    FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL SEKFDKVRLL 2650
    QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN 2700
    KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN 2750
    KYNYPPIFDV LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI 2800
    KQSISDAELL LSSTIKCSPN LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL 2850
    KLTLKELCSL IEEKTASETR VTFAEYIFPA LDLAESSKSL EELGEAWITF 2900
    GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS WRNVRKVISG 2950
    DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ 3000
    IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY 3050
    IYSINFGFDL LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR 3100
    FFKKGDMEDT SIEKVLMYFL TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR 3150
    RFRQEQEENE KSNMFKFNDN SDDYEADFRK LFPDYEDTAL VTNEKDISSP 3200
    ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL SEDLKNTRIE 3250
    ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET 3300
    VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY 3350
    LAEWEKYASS EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS 3400
    IGKWWFYLYE SIVISNFVSE KKETAPNATL LVSSLNLFFS KSTLGEFNAR 3450
    LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK FYYQFKPLID ERITNGKKSL 3500
    EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR DLLNGDAKTI 3550
    IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN 3600
    IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK 3650
    KRLAYLKTQK SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP 3700
    FNNEYLNSSD AFFFKILDLL PKLRSAASNP SDDIPVAAIE RGMALAQSLM 3750
    FSLITVRHPL SEFTNDYCKI NGMMLDLEHF TCLKGDIVHS SLKANVDNVR 3800
    LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL SSFFVHFNSS 3850
    RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG 3900
    PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS 3950
    ASFKKVMVNV KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL 4000
    PVITRYYNAM TVVLERSRIY YTNTSRGMYI LSTILHSLAK NGFCSPQPPS 4050
    EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD EDLTEDAQNE NKEQQDKDER 4100
    DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL DEEIDDLNED 4150
    DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE 4200
    GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI 4250
    ETLDLPEDMN LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI 4300
    ESDNENDEPG PEEDAGETET ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ 4350
    AMSDEEELKQ DAAMEENKEK GGEQNTEGLD GVEEKADTED IDQEAAVQQD 4400
    SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN EESREEATAA 4450
    LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE 4500
    TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE 4550
    EEMLSDIDAH DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS 4600
    EIQSLIENIE DNPPDASASL TPERSLEESR ELWHKSEIST ADLVSRLGEQ 4650
    LRLILEPTLA TKLKGDYKTG KRLNMKRIIP YIASQFRKDK IWLRRTKPSK 4700
    RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA GGLSIVKFGE 4750
    NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM 4800
    VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES 4850
    ILDMSQVNYI PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL 4900
    RQYFTDLASS 4910
    Length:4,910
    Mass (Da):559,308
    Last modified:November 1, 1996 - v1
    Checksum:iE4E873BEDF6E1E5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53876 Genomic DNA. Translation: AAB67548.1.
    Z73278 Genomic DNA. Translation: CAA97671.1.
    X89514 Genomic DNA. Translation: CAA61684.1.
    Z73279 Genomic DNA. Translation: CAA97673.1.
    BK006945 Genomic DNA. Translation: DAA09422.1.
    PIRiS64942.
    RefSeqiNP_013207.1. NM_001181993.1.

    Genome annotation databases

    EnsemblFungiiYLR106C; YLR106C; YLR106C.
    GeneIDi850796.
    KEGGisce:YLR106C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53876 Genomic DNA. Translation: AAB67548.1 .
    Z73278 Genomic DNA. Translation: CAA97671.1 .
    X89514 Genomic DNA. Translation: CAA61684.1 .
    Z73279 Genomic DNA. Translation: CAA97673.1 .
    BK006945 Genomic DNA. Translation: DAA09422.1 .
    PIRi S64942.
    RefSeqi NP_013207.1. NM_001181993.1.

    3D structure databases

    ProteinModelPortali Q12019.
    SMRi Q12019. Positions 649-680, 816-1234, 1364-1394, 1740-1837, 2048-2081.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31379. 63 interactions.
    DIPi DIP-6285N.
    IntActi Q12019. 39 interactions.
    MINTi MINT-613312.
    STRINGi 4932.YLR106C.

    Proteomic databases

    MaxQBi Q12019.
    PaxDbi Q12019.
    PeptideAtlasi Q12019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR106C ; YLR106C ; YLR106C .
    GeneIDi 850796.
    KEGGi sce:YLR106C.

    Organism-specific databases

    CYGDi YLR106c.
    SGDi S000004096. MDN1.

    Phylogenomic databases

    eggNOGi COG5271.
    GeneTreei ENSGT00550000074802.
    HOGENOMi HOG000164494.
    KOi K14572.
    OMAi RIFLTMD.
    OrthoDBi EOG7JMGNQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32254-MONOMER.

    Miscellaneous databases

    NextBioi 967011.
    PROi Q12019.

    Gene expression databases

    Genevestigatori Q12019.

    Family and domain databases

    Gene3Di 3.40.50.300. 12 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011704. ATPase_dyneun-rel_AAA.
    IPR012099. Midasin.
    IPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF07728. AAA_5. 8 hits.
    [Graphical view ]
    PIRSFi PIRSF010340. Midasin. 1 hit.
    SMARTi SM00382. AAA. 6 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 9 hits.
    SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Sequence analysis of a 37.6 kbp cosmid clone from the right arm of Saccharomyces cerevisiae chromosome XII, carrying YAP3, HOG1, SNR6, tRNA-Arg3 and 23 new open reading frames, among which several homologies to proteins involved in cell division control and to mammalian growth factors and other animal proteins are found."
      Verhasselt P., Volckaert G.
      Yeast 13:241-250(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-115.
      Strain: ATCC 90840 / EAY235 / FY23.
    4. "Identification of a 60S preribosomal particle that is closely linked to nuclear export."
      Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
      Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT.
    5. "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
      Garbarino J.E., Gibbons I.R.
      BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
    6. "60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm."
      Nissan T.A., Bassler J., Petfalski E., Tollervey D., Hurt E.
      EMBO J. 21:5539-5547(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN PRE-60S RIBOSOMES, IDENTIFICATION BY MASS SPECTROMETRY.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
      Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
      J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
      Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
      Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1026; SER-2971; SER-4353 AND THR-4388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits."
      Ulbrich C., Diepholz M., Bassler J., Kressler D., Pertschy B., Galani K., Bottcher B., Hurt E.
      Cell 138:911-922(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH THE PRE-60S PARTICLE, INTERACTION WITH RSA4.
    12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2971 AND SER-4555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly."
      Bassler J., Kallas M., Pertschy B., Ulbrich C., Thoms M., Hurt E.
      Mol. Cell 38:712-721(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RSA4 AND YTM1.

    Entry informationi

    Entry nameiMDN1_YEAST
    AccessioniPrimary (citable) accession number: Q12019
    Secondary accession number(s): D6VYA6, Q7LGX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 538 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3