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Q12019 (MDN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Midasin
Alternative name(s):
MIDAS-containing protein
Ribosome export/assembly protein 1
Gene names
Name:MDN1
Synonyms:REA1
Ordered Locus Names:YLR106C
ORF Names:L8004.13
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length4910 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. Mediates ATP-dependent remodeling of the pre-ribosome just prior to export to allow maturation of 60S subunits into export-competent particles. Removes the ribosome biogenesis factor RSA4 from pre-60S ribosomal subunits in the nucleoplasm to drive nuclear export of the subunit. Involved in 3' processing of the 5.8S rRNA. Ref.7 Ref.8 Ref.10 Ref.12

Subunit structure

Associates with pre-60S ribosomes in the nucleoplasm. Interacts with RSA4 and YTM1. Ref.3 Ref.5 Ref.8 Ref.10 Ref.12

Subcellular location

Nucleus Ref.3 Ref.4 Ref.7.

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the midasin family.

Contains 1 VWFA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSA4P253826EBI-10633,EBI-21980

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 49104910Midasin
PRO_0000096337

Regions

Domain4704 – 4899196VWFA
Nucleotide binding315 – 3228ATP Potential
Nucleotide binding653 – 6608ATP Potential
Nucleotide binding1083 – 10908ATP Potential
Nucleotide binding1368 – 13758ATP Potential
Nucleotide binding1747 – 17548ATP Potential
Nucleotide binding2054 – 20618ATP Potential
Compositional bias768 – 7714Poly-Lys
Compositional bias2904 – 29074Poly-Leu
Compositional bias4136 – 41394Poly-Glu

Amino acid modifications

Modified residue10261Phosphothreonine Ref.9
Modified residue29711Phosphoserine Ref.9 Ref.11
Modified residue43531Phosphoserine Ref.9
Modified residue43881Phosphothreonine Ref.9
Modified residue45551Phosphoserine Ref.11

Sequences

Sequence LengthMass (Da)Tools
Q12019 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E4E873BEDF6E1E5B

FASTA4,910559,308
        10         20         30         40         50         60 
MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG TILHSRSITG 

        70         80         90        100        110        120 
HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP VAMPLIEDYL DKENDHFITI 

       130        140        150        160        170        180 
LQNPSTQKDS DMFKILLAYY RLLYHNKEVF ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL 

       190        200        210        220        230        240 
KVLSLYLDMG EKTLNDMLDT YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV 

       250        260        270        280        290        300 
PECFTIEKKS SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ 

       310        320        330        340        350        360 
LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK LLIGTYTSGD 

       370        380        390        400        410        420 
KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS LLEKRELTIP SRGETVKAAN 

       430        440        450        460        470        480 
GFQLISTVRI NEDHQKDSSN KIYNLNMIGM RIWNVIELEE PSEEDLTHIL AQKFPILTNL 

       490        500        510        520        530        540 
IPKLIDSYKN VKSIYMNTKF ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI 

       550        560        570        580        590        600 
QSSVYDSIFS EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD 

       610        620        630        640        650        660 
SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL LVGETGTGKT 

       670        680        690        700        710        720 
TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV AVPIQENFET LFNATFSLKK 

       730        740        750        760        770        780 
NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM AQSILKITNT ENENENAKKK KRRLNTHEKK 

       790        800        810        820        830        840 
LLLDKWADFN DSVKKFEAQS SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE 

       850        860        870        880        890        900 
SISDLLTEPD SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY 

       910        920        930        940        950        960 
VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV DGSNQKPHFS 

       970        980        990       1000       1010       1020 
IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS EAILKPVIEK FTLGRLKNVK 

      1030       1040       1050       1060       1070       1080 
SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ EQAHYIITPF VEKNMMNLVR ATSGKRFPVL 

      1090       1100       1110       1120       1130       1140 
IQGPTSSGKT SMIKYLADIT GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA 

      1150       1160       1170       1180       1190       1200 
LRKGYWIVLD ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY 

      1210       1220       1230       1240       1250       1260 
GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR QLSIERSASR 

      1270       1280       1290       1300       1310       1320 
LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC RTPQEKVTVK KTLEKVMKVK 

      1330       1340       1350       1360       1370       1380 
LDMDQYYASL EDKSLEAIGS VTWTKGMRRL SVLVSSCLKN KEPVLLVGET GCGKTTICQL 

      1390       1400       1410       1420       1430       1440 
LAQFMGRELI TLNAHQNTET GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE 

      1450       1460       1470       1480       1490       1500 
LLQLYSKSDN KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS 

      1510       1520       1530       1540       1550       1560 
VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL SPALRNRFTE 

      1570       1580       1590       1600       1610       1620 
IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK KLGGGNATSG VISLRDILAW 

      1630       1640       1650       1660       1670       1680 
VEFINKVFPK IQNKSTALIQ GASMVFIDAL GTNNTAYLAE NENDLKSLRT ECIIQLLKLC 

      1690       1700       1710       1720       1730       1740 
GDDLELQQIE TNEIIVTQDE LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH 

      1750       1760       1770       1780       1790       1800 
KPILLEGSPG VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA 

      1810       1820       1830       1840       1850       1860 
PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH PNFLVFAAQN 

      1870       1880       1890       1900       1910       1920 
PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY PSIEPDIIAK MIKLMSTLED 

      1930       1940       1950       1960       1970       1980 
QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN QYSICEDVDV FDFVDIIVKQ RFRTISDKNK 

      1990       2000       2010       2020       2030       2040 
AQLLIEDIFG KFSTKENFFK LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV 

      2050       2060       2070       2080       2090       2100 
LKAINNNWPL VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR 

      2110       2120       2130       2140       2150       2160 
QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF QDFRNRFNRF 

      2170       2180       2190       2200       2210       2220 
FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV KAVEKGHWLI LDNANLCSPS 

      2230       2240       2250       2260       2270       2280 
VLDRLNSLLE IDGSLLINEC SQEDGQPRVL KPHPNFRLFL TMDPKYGELS RAMRNRGVEI 

      2290       2300       2310       2320       2330       2340 
YIDELHSRST AFDRLTLGFE LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC 

      2350       2360       2370       2380       2390       2400 
IFAQVHDILL LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT 

      2410       2420       2430       2440       2450       2460 
FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV SKYSDKIKSP 

      2470       2480       2490       2500       2510       2520 
ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS AAAFNGRHLK NIPRIPIFCI 

      2530       2540       2550       2560       2570       2580 
LYNILTVMSE NLKTESLFCG SNQYQYYWDL LVIVIAALET AVTKDEARLR VYKELIDSWI 

      2590       2600       2610       2620       2630       2640 
ASVKSKSDIE ITPFLNINLE FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL 

      2650       2660       2670       2680       2690       2700 
SEKFDKVRLL QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN 

      2710       2720       2730       2740       2750       2760 
KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN KYNYPPIFDV 

      2770       2780       2790       2800       2810       2820 
LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI KQSISDAELL LSSTIKCSPN 

      2830       2840       2850       2860       2870       2880 
LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL KLTLKELCSL IEEKTASETR VTFAEYIFPA 

      2890       2900       2910       2920       2930       2940 
LDLAESSKSL EELGEAWITF GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS 

      2950       2960       2970       2980       2990       3000 
WRNVRKVISG DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ 

      3010       3020       3030       3040       3050       3060 
IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY IYSINFGFDL 

      3070       3080       3090       3100       3110       3120 
LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR FFKKGDMEDT SIEKVLMYFL 

      3130       3140       3150       3160       3170       3180 
TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR RFRQEQEENE KSNMFKFNDN SDDYEADFRK 

      3190       3200       3210       3220       3230       3240 
LFPDYEDTAL VTNEKDISSP ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL 

      3250       3260       3270       3280       3290       3300 
SEDLKNTRIE ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET 

      3310       3320       3330       3340       3350       3360 
VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY LAEWEKYASS 

      3370       3380       3390       3400       3410       3420 
EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS IGKWWFYLYE SIVISNFVSE 

      3430       3440       3450       3460       3470       3480 
KKETAPNATL LVSSLNLFFS KSTLGEFNAR LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK 

      3490       3500       3510       3520       3530       3540 
FYYQFKPLID ERITNGKKSL EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR 

      3550       3560       3570       3580       3590       3600 
DLLNGDAKTI IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN 

      3610       3620       3630       3640       3650       3660 
IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK KRLAYLKTQK 

      3670       3680       3690       3700       3710       3720 
SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP FNNEYLNSSD AFFFKILDLL 

      3730       3740       3750       3760       3770       3780 
PKLRSAASNP SDDIPVAAIE RGMALAQSLM FSLITVRHPL SEFTNDYCKI NGMMLDLEHF 

      3790       3800       3810       3820       3830       3840 
TCLKGDIVHS SLKANVDNVR LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL 

      3850       3860       3870       3880       3890       3900 
SSFFVHFNSS RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG 

      3910       3920       3930       3940       3950       3960 
PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS ASFKKVMVNV 

      3970       3980       3990       4000       4010       4020 
KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL PVITRYYNAM TVVLERSRIY 

      4030       4040       4050       4060       4070       4080 
YTNTSRGMYI LSTILHSLAK NGFCSPQPPS EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD 

      4090       4100       4110       4120       4130       4140 
EDLTEDAQNE NKEQQDKDER DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL 

      4150       4160       4170       4180       4190       4200 
DEEIDDLNED DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE 

      4210       4220       4230       4240       4250       4260 
GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI ETLDLPEDMN 

      4270       4280       4290       4300       4310       4320 
LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI ESDNENDEPG PEEDAGETET 

      4330       4340       4350       4360       4370       4380 
ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ AMSDEEELKQ DAAMEENKEK GGEQNTEGLD 

      4390       4400       4410       4420       4430       4440 
GVEEKADTED IDQEAAVQQD SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN 

      4450       4460       4470       4480       4490       4500 
EESREEATAA LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE 

      4510       4520       4530       4540       4550       4560 
TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE EEMLSDIDAH 

      4570       4580       4590       4600       4610       4620 
DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS EIQSLIENIE DNPPDASASL 

      4630       4640       4650       4660       4670       4680 
TPERSLEESR ELWHKSEIST ADLVSRLGEQ LRLILEPTLA TKLKGDYKTG KRLNMKRIIP 

      4690       4700       4710       4720       4730       4740 
YIASQFRKDK IWLRRTKPSK RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA 

      4750       4760       4770       4780       4790       4800 
GGLSIVKFGE NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM 

      4810       4820       4830       4840       4850       4860 
VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES ILDMSQVNYI 

      4870       4880       4890       4900       4910 
PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL RQYFTDLASS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Identification of a 60S preribosomal particle that is closely linked to nuclear export."
Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SUBUNIT.
[4]"Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
Garbarino J.E., Gibbons I.R.
BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[5]"60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm."
Nissan T.A., Bassler J., Petfalski E., Tollervey D., Hurt E.
EMBO J. 21:5539-5547(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN PRE-60S RIBOSOMES, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1026; SER-2971; SER-4353 AND THR-4388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits."
Ulbrich C., Diepholz M., Bassler J., Kressler D., Pertschy B., Galani K., Bottcher B., Hurt E.
Cell 138:911-922(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ASSOCIATION WITH THE PRE-60S PARTICLE, INTERACTION WITH RSA4.
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2971 AND SER-4555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly."
Bassler J., Kallas M., Pertschy B., Ulbrich C., Thoms M., Hurt E.
Mol. Cell 38:712-721(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RSA4 AND YTM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53876 Genomic DNA. Translation: AAB67548.1.
Z73278 Genomic DNA. Translation: CAA97671.1.
BK006945 Genomic DNA. Translation: DAA09422.1.
PIRS64942.
RefSeqNP_013207.1. NM_001181993.1.

3D structure databases

ProteinModelPortalQ12019.
SMRQ12019. Positions 295-472, 649-684, 816-1235, 1363-1388, 1479-1580, 1733-1897, 2050-2079, 2199-2239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31379. 63 interactions.
DIPDIP-6285N.
IntActQ12019. 39 interactions.
MINTMINT-613312.
STRING4932.YLR106C.

Proteomic databases

PaxDbQ12019.
PeptideAtlasQ12019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR106C; YLR106C; YLR106C.
GeneID850796.
KEGGsce:YLR106C.

Organism-specific databases

CYGDYLR106c.
SGDS000004096. MDN1.

Phylogenomic databases

eggNOGCOG5271.
GeneTreeENSGT00550000074802.
HOGENOMHOG000164494.
KOK14572.
OMAWQPHESG.
OrthoDBEOG7JMGNQ.

Enzyme and pathway databases

BioCycYEAST:G3O-32254-MONOMER.

Gene expression databases

GenevestigatorQ12019.

Family and domain databases

Gene3D3.40.50.300. 12 hits.
InterProIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR002035. VWF_A.
[Graphical view]
PfamPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFPIRSF010340. Midasin. 1 hit.
SMARTSM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 9 hits.
SSF53300. SSF53300. 1 hit.
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio967011.
PROQ12019.

Entry information

Entry nameMDN1_YEAST
AccessionPrimary (citable) accession number: Q12019
Secondary accession number(s): D6VYA6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families