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Q12019

- MDN1_YEAST

UniProt

Q12019 - MDN1_YEAST

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Protein

Midasin

Gene

MDN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. Mediates ATP-dependent remodeling of the pre-ribosome just prior to export to allow maturation of 60S subunits into export-competent particles. Removes the ribosome biogenesis factor RSA4 from pre-60S ribosomal subunits in the nucleoplasm to drive nuclear export of the subunit. Involved in 3' processing of the 5.8S rRNA.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi315 – 3228ATPSequence Analysis
Nucleotide bindingi653 – 6608ATPSequence Analysis
Nucleotide bindingi1083 – 10908ATPSequence Analysis
Nucleotide bindingi1368 – 13758ATPSequence Analysis
Nucleotide bindingi1747 – 17548ATPSequence Analysis
Nucleotide bindingi2054 – 20618ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: SGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. protein complex assembly Source: InterPro
  3. ribosomal large subunit assembly Source: SGD
  4. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Midasin
Alternative name(s):
MIDAS-containing protein
Ribosome export/assembly protein 1
Gene namesi
Name:MDN1
Synonyms:REA1
Ordered Locus Names:YLR106C
ORF Names:L2901, L8004.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR106c.
SGDiS000004096. MDN1.

Subcellular locationi

Nucleus 3 Publications

GO - Cellular componenti

  1. nucleoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 49104910MidasinPRO_0000096337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1026 – 10261Phosphothreonine1 Publication
Modified residuei2971 – 29711Phosphoserine2 Publications
Modified residuei4353 – 43531Phosphoserine1 Publication
Modified residuei4388 – 43881Phosphothreonine1 Publication
Modified residuei4555 – 45551Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12019.
PaxDbiQ12019.
PeptideAtlasiQ12019.

Expressioni

Gene expression databases

GenevestigatoriQ12019.

Interactioni

Subunit structurei

Associates with pre-60S ribosomes in the nucleoplasm. Interacts with RSA4 and YTM1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSA4P253826EBI-10633,EBI-21980

Protein-protein interaction databases

BioGridi31379. 63 interactions.
DIPiDIP-6285N.
IntActiQ12019. 39 interactions.
MINTiMINT-613312.
STRINGi4932.YLR106C.

Structurei

3D structure databases

ProteinModelPortaliQ12019.
SMRiQ12019. Positions 816-1196, 1740-1837, 2047-2072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4704 – 4899196VWFAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi768 – 7714Poly-Lys
Compositional biasi2904 – 29074Poly-Leu
Compositional biasi4136 – 41394Poly-Glu

Sequence similaritiesi

Belongs to the midasin family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5271.
GeneTreeiENSGT00550000074802.
HOGENOMiHOG000164494.
InParanoidiQ12019.
KOiK14572.
OMAiRIFLTMD.
OrthoDBiEOG7JMGNQ.

Family and domain databases

Gene3Di3.40.50.300. 12 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07728. AAA_5. 8 hits.
[Graphical view]
PIRSFiPIRSF010340. Midasin. 1 hit.
SMARTiSM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 9 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG
60 70 80 90 100
TILHSRSITG HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP
110 120 130 140 150
VAMPLIEDYL DKENDHFITI LQNPSTQKDS DMFKILLAYY RLLYHNKEVF
160 170 180 190 200
ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL KVLSLYLDMG EKTLNDMLDT
210 220 230 240 250
YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV PECFTIEKKS
260 270 280 290 300
SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ
310 320 330 340 350
LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK
360 370 380 390 400
LLIGTYTSGD KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS
410 420 430 440 450
LLEKRELTIP SRGETVKAAN GFQLISTVRI NEDHQKDSSN KIYNLNMIGM
460 470 480 490 500
RIWNVIELEE PSEEDLTHIL AQKFPILTNL IPKLIDSYKN VKSIYMNTKF
510 520 530 540 550
ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI QSSVYDSIFS
560 570 580 590 600
EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD
610 620 630 640 650
SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL
660 670 680 690 700
LVGETGTGKT TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV
710 720 730 740 750
AVPIQENFET LFNATFSLKK NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM
760 770 780 790 800
AQSILKITNT ENENENAKKK KRRLNTHEKK LLLDKWADFN DSVKKFEAQS
810 820 830 840 850
SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE SISDLLTEPD
860 870 880 890 900
SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY
910 920 930 940 950
VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV
960 970 980 990 1000
DGSNQKPHFS IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS
1010 1020 1030 1040 1050
EAILKPVIEK FTLGRLKNVK SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ
1060 1070 1080 1090 1100
EQAHYIITPF VEKNMMNLVR ATSGKRFPVL IQGPTSSGKT SMIKYLADIT
1110 1120 1130 1140 1150
GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA LRKGYWIVLD
1160 1170 1180 1190 1200
ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY
1210 1220 1230 1240 1250
GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR
1260 1270 1280 1290 1300
QLSIERSASR LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC
1310 1320 1330 1340 1350
RTPQEKVTVK KTLEKVMKVK LDMDQYYASL EDKSLEAIGS VTWTKGMRRL
1360 1370 1380 1390 1400
SVLVSSCLKN KEPVLLVGET GCGKTTICQL LAQFMGRELI TLNAHQNTET
1410 1420 1430 1440 1450
GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE LLQLYSKSDN
1460 1470 1480 1490 1500
KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS
1510 1520 1530 1540 1550
VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL
1560 1570 1580 1590 1600
SPALRNRFTE IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK
1610 1620 1630 1640 1650
KLGGGNATSG VISLRDILAW VEFINKVFPK IQNKSTALIQ GASMVFIDAL
1660 1670 1680 1690 1700
GTNNTAYLAE NENDLKSLRT ECIIQLLKLC GDDLELQQIE TNEIIVTQDE
1710 1720 1730 1740 1750
LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH KPILLEGSPG
1760 1770 1780 1790 1800
VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA
1810 1820 1830 1840 1850
PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH
1860 1870 1880 1890 1900
PNFLVFAAQN PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY
1910 1920 1930 1940 1950
PSIEPDIIAK MIKLMSTLED QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN
1960 1970 1980 1990 2000
QYSICEDVDV FDFVDIIVKQ RFRTISDKNK AQLLIEDIFG KFSTKENFFK
2010 2020 2030 2040 2050
LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV LKAINNNWPL
2060 2070 2080 2090 2100
VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR
2110 2120 2130 2140 2150
QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF
2160 2170 2180 2190 2200
QDFRNRFNRF FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV
2210 2220 2230 2240 2250
KAVEKGHWLI LDNANLCSPS VLDRLNSLLE IDGSLLINEC SQEDGQPRVL
2260 2270 2280 2290 2300
KPHPNFRLFL TMDPKYGELS RAMRNRGVEI YIDELHSRST AFDRLTLGFE
2310 2320 2330 2340 2350
LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC IFAQVHDILL
2360 2370 2380 2390 2400
LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT
2410 2420 2430 2440 2450
FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV
2460 2470 2480 2490 2500
SKYSDKIKSP ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS
2510 2520 2530 2540 2550
AAAFNGRHLK NIPRIPIFCI LYNILTVMSE NLKTESLFCG SNQYQYYWDL
2560 2570 2580 2590 2600
LVIVIAALET AVTKDEARLR VYKELIDSWI ASVKSKSDIE ITPFLNINLE
2610 2620 2630 2640 2650
FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL SEKFDKVRLL
2660 2670 2680 2690 2700
QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN
2710 2720 2730 2740 2750
KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN
2760 2770 2780 2790 2800
KYNYPPIFDV LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI
2810 2820 2830 2840 2850
KQSISDAELL LSSTIKCSPN LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL
2860 2870 2880 2890 2900
KLTLKELCSL IEEKTASETR VTFAEYIFPA LDLAESSKSL EELGEAWITF
2910 2920 2930 2940 2950
GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS WRNVRKVISG
2960 2970 2980 2990 3000
DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ
3010 3020 3030 3040 3050
IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY
3060 3070 3080 3090 3100
IYSINFGFDL LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR
3110 3120 3130 3140 3150
FFKKGDMEDT SIEKVLMYFL TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR
3160 3170 3180 3190 3200
RFRQEQEENE KSNMFKFNDN SDDYEADFRK LFPDYEDTAL VTNEKDISSP
3210 3220 3230 3240 3250
ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL SEDLKNTRIE
3260 3270 3280 3290 3300
ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET
3310 3320 3330 3340 3350
VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY
3360 3370 3380 3390 3400
LAEWEKYASS EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS
3410 3420 3430 3440 3450
IGKWWFYLYE SIVISNFVSE KKETAPNATL LVSSLNLFFS KSTLGEFNAR
3460 3470 3480 3490 3500
LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK FYYQFKPLID ERITNGKKSL
3510 3520 3530 3540 3550
EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR DLLNGDAKTI
3560 3570 3580 3590 3600
IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN
3610 3620 3630 3640 3650
IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK
3660 3670 3680 3690 3700
KRLAYLKTQK SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP
3710 3720 3730 3740 3750
FNNEYLNSSD AFFFKILDLL PKLRSAASNP SDDIPVAAIE RGMALAQSLM
3760 3770 3780 3790 3800
FSLITVRHPL SEFTNDYCKI NGMMLDLEHF TCLKGDIVHS SLKANVDNVR
3810 3820 3830 3840 3850
LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL SSFFVHFNSS
3860 3870 3880 3890 3900
RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG
3910 3920 3930 3940 3950
PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS
3960 3970 3980 3990 4000
ASFKKVMVNV KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL
4010 4020 4030 4040 4050
PVITRYYNAM TVVLERSRIY YTNTSRGMYI LSTILHSLAK NGFCSPQPPS
4060 4070 4080 4090 4100
EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD EDLTEDAQNE NKEQQDKDER
4110 4120 4130 4140 4150
DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL DEEIDDLNED
4160 4170 4180 4190 4200
DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE
4210 4220 4230 4240 4250
GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI
4260 4270 4280 4290 4300
ETLDLPEDMN LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI
4310 4320 4330 4340 4350
ESDNENDEPG PEEDAGETET ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ
4360 4370 4380 4390 4400
AMSDEEELKQ DAAMEENKEK GGEQNTEGLD GVEEKADTED IDQEAAVQQD
4410 4420 4430 4440 4450
SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN EESREEATAA
4460 4470 4480 4490 4500
LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE
4510 4520 4530 4540 4550
TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE
4560 4570 4580 4590 4600
EEMLSDIDAH DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS
4610 4620 4630 4640 4650
EIQSLIENIE DNPPDASASL TPERSLEESR ELWHKSEIST ADLVSRLGEQ
4660 4670 4680 4690 4700
LRLILEPTLA TKLKGDYKTG KRLNMKRIIP YIASQFRKDK IWLRRTKPSK
4710 4720 4730 4740 4750
RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA GGLSIVKFGE
4760 4770 4780 4790 4800
NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM
4810 4820 4830 4840 4850
VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES
4860 4870 4880 4890 4900
ILDMSQVNYI PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL
4910
RQYFTDLASS
Length:4,910
Mass (Da):559,308
Last modified:November 1, 1996 - v1
Checksum:iE4E873BEDF6E1E5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53876 Genomic DNA. Translation: AAB67548.1.
Z73278 Genomic DNA. Translation: CAA97671.1.
X89514 Genomic DNA. Translation: CAA61684.1.
Z73279 Genomic DNA. Translation: CAA97673.1.
BK006945 Genomic DNA. Translation: DAA09422.1.
PIRiS64942.
RefSeqiNP_013207.1. NM_001181993.1.

Genome annotation databases

EnsemblFungiiYLR106C; YLR106C; YLR106C.
GeneIDi850796.
KEGGisce:YLR106C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53876 Genomic DNA. Translation: AAB67548.1 .
Z73278 Genomic DNA. Translation: CAA97671.1 .
X89514 Genomic DNA. Translation: CAA61684.1 .
Z73279 Genomic DNA. Translation: CAA97673.1 .
BK006945 Genomic DNA. Translation: DAA09422.1 .
PIRi S64942.
RefSeqi NP_013207.1. NM_001181993.1.

3D structure databases

ProteinModelPortali Q12019.
SMRi Q12019. Positions 816-1196, 1740-1837, 2047-2072.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31379. 63 interactions.
DIPi DIP-6285N.
IntActi Q12019. 39 interactions.
MINTi MINT-613312.
STRINGi 4932.YLR106C.

Proteomic databases

MaxQBi Q12019.
PaxDbi Q12019.
PeptideAtlasi Q12019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR106C ; YLR106C ; YLR106C .
GeneIDi 850796.
KEGGi sce:YLR106C.

Organism-specific databases

CYGDi YLR106c.
SGDi S000004096. MDN1.

Phylogenomic databases

eggNOGi COG5271.
GeneTreei ENSGT00550000074802.
HOGENOMi HOG000164494.
InParanoidi Q12019.
KOi K14572.
OMAi RIFLTMD.
OrthoDBi EOG7JMGNQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-32254-MONOMER.

Miscellaneous databases

NextBioi 967011.
PROi Q12019.

Gene expression databases

Genevestigatori Q12019.

Family and domain databases

Gene3Di 3.40.50.300. 12 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR012099. Midasin.
IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF07728. AAA_5. 8 hits.
[Graphical view ]
PIRSFi PIRSF010340. Midasin. 1 hit.
SMARTi SM00382. AAA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 9 hits.
SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Sequence analysis of a 37.6 kbp cosmid clone from the right arm of Saccharomyces cerevisiae chromosome XII, carrying YAP3, HOG1, SNR6, tRNA-Arg3 and 23 new open reading frames, among which several homologies to proteins involved in cell division control and to mammalian growth factors and other animal proteins are found."
    Verhasselt P., Volckaert G.
    Yeast 13:241-250(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-115.
    Strain: ATCC 90840 / EAY235 / FY23.
  4. "Identification of a 60S preribosomal particle that is closely linked to nuclear export."
    Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E.
    Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT.
  5. "Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."
    Garbarino J.E., Gibbons I.R.
    BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
  6. "60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm."
    Nissan T.A., Bassler J., Petfalski E., Tollervey D., Hurt E.
    EMBO J. 21:5539-5547(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN PRE-60S RIBOSOMES, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits."
    Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E.
    J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits."
    Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E.
    Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1026; SER-2971; SER-4353 AND THR-4388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits."
    Ulbrich C., Diepholz M., Bassler J., Kressler D., Pertschy B., Galani K., Bottcher B., Hurt E.
    Cell 138:911-922(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH THE PRE-60S PARTICLE, INTERACTION WITH RSA4.
  12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2971 AND SER-4555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly."
    Bassler J., Kallas M., Pertschy B., Ulbrich C., Thoms M., Hurt E.
    Mol. Cell 38:712-721(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RSA4 AND YTM1.

Entry informationi

Entry nameiMDN1_YEAST
AccessioniPrimary (citable) accession number: Q12019
Secondary accession number(s): D6VYA6, Q7LGX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3