Q12019 (MDN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Midasin

Alternative name(s):
MIDAS-containing protein
Ribosome export/assembly protein 1

Gene names

Name:	MDN1
Synonyms:	REA1
Ordered Locus Names:	YLR106C
ORF Names:	L8004.13

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	4910 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. Mediates ATP-dependent remodeling of the pre-ribosome just prior to export to allow maturation of 60S subunits into export-competent particles. Removes the ribosome biogenesis factor RSA4 from pre-60S ribosomal subunits in the nucleoplasm to drive nuclear export of the subunit. Involved in 3' processing of the 5.8S rRNA. Ref.7 Ref.8 Ref.11 Ref.12
Subunit structure	Associates with pre-60S ribosomes in the nucleoplasm. Interacts with RSA4 and YTM1. Ref.3 Ref.5 Ref.8 Ref.11 Ref.12
Subcellular location	Nucleus Ref.3 Ref.4 Ref.7.
Miscellaneous	Present with 538 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the midasin family. Contains 1 VWFA domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein complex assembly Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from mutant phenotype PubMed 12837249. Source: SGD ribosomal large subunit assembly Inferred from mutant phenotype Ref.7. Source: SGD
Cellular_component	mitochondrion Inferred from direct assay PubMed 14576278PubMed 16823961. Source: SGD nucleoplasm Inferred from direct assay Ref.7. Source: SGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from sequence or structural similarity Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RSA4	P25382	6	EBI-10633,EBI-21980

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4910	4910	Midasin		PRO_0000096337
Regions
	Domain	4704 – 4899	196	VWFA
	Nucleotide binding	315 – 322	8	ATP Potential
	Nucleotide binding	653 – 660	8	ATP Potential
	Nucleotide binding	1083 – 1090	8	ATP Potential
	Nucleotide binding	1368 – 1375	8	ATP Potential
	Nucleotide binding	1747 – 1754	8	ATP Potential
	Nucleotide binding	2054 – 2061	8	ATP Potential
	Compositional bias	768 – 771	4	Poly-Lys
	Compositional bias	2904 – 2907	4	Poly-Leu
	Compositional bias	4136 – 4139	4	Poly-Glu
Amino acid modifications
	Modified residue	478	1	Phosphothreonine Ref.10
	Modified residue	1026	1	Phosphothreonine Ref.10
	Modified residue	2971	1	Phosphoserine Ref.10
	Modified residue	4353	1	Phosphoserine Ref.10
	Modified residue	4388	1	Phosphothreonine Ref.9 Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Q12019 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E4E873BEDF6E1E5B	FASTA	4,910	559,308
	10 20 30 40 50 60 MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG TILHSRSITG 70 80 90 100 110 120 HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP VAMPLIEDYL DKENDHFITI 130 140 150 160 170 180 LQNPSTQKDS DMFKILLAYY RLLYHNKEVF ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL 190 200 210 220 230 240 KVLSLYLDMG EKTLNDMLDT YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV 250 260 270 280 290 300 PECFTIEKKS SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ 310 320 330 340 350 360 LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK LLIGTYTSGD 370 380 390 400 410 420 KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS LLEKRELTIP SRGETVKAAN 430 440 450 460 470 480 GFQLISTVRI NEDHQKDSSN KIYNLNMIGM RIWNVIELEE PSEEDLTHIL AQKFPILTNL 490 500 510 520 530 540 IPKLIDSYKN VKSIYMNTKF ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI 550 560 570 580 590 600 QSSVYDSIFS EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD 610 620 630 640 650 660 SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL LVGETGTGKT 670 680 690 700 710 720 TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV AVPIQENFET LFNATFSLKK 730 740 750 760 770 780 NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM AQSILKITNT ENENENAKKK KRRLNTHEKK 790 800 810 820 830 840 LLLDKWADFN DSVKKFEAQS SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE 850 860 870 880 890 900 SISDLLTEPD SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY 910 920 930 940 950 960 VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV DGSNQKPHFS 970 980 990 1000 1010 1020 IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS EAILKPVIEK FTLGRLKNVK 1030 1040 1050 1060 1070 1080 SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ EQAHYIITPF VEKNMMNLVR ATSGKRFPVL 1090 1100 1110 1120 1130 1140 IQGPTSSGKT SMIKYLADIT GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA 1150 1160 1170 1180 1190 1200 LRKGYWIVLD ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY 1210 1220 1230 1240 1250 1260 GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR QLSIERSASR 1270 1280 1290 1300 1310 1320 LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC RTPQEKVTVK KTLEKVMKVK 1330 1340 1350 1360 1370 1380 LDMDQYYASL EDKSLEAIGS VTWTKGMRRL SVLVSSCLKN KEPVLLVGET GCGKTTICQL 1390 1400 1410 1420 1430 1440 LAQFMGRELI TLNAHQNTET GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE 1450 1460 1470 1480 1490 1500 LLQLYSKSDN KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS 1510 1520 1530 1540 1550 1560 VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL SPALRNRFTE 1570 1580 1590 1600 1610 1620 IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK KLGGGNATSG VISLRDILAW 1630 1640 1650 1660 1670 1680 VEFINKVFPK IQNKSTALIQ GASMVFIDAL GTNNTAYLAE NENDLKSLRT ECIIQLLKLC 1690 1700 1710 1720 1730 1740 GDDLELQQIE TNEIIVTQDE LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH 1750 1760 1770 1780 1790 1800 KPILLEGSPG VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA 1810 1820 1830 1840 1850 1860 PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH PNFLVFAAQN 1870 1880 1890 1900 1910 1920 PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY PSIEPDIIAK MIKLMSTLED 1930 1940 1950 1960 1970 1980 QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN QYSICEDVDV FDFVDIIVKQ RFRTISDKNK 1990 2000 2010 2020 2030 2040 AQLLIEDIFG KFSTKENFFK LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV 2050 2060 2070 2080 2090 2100 LKAINNNWPL VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR 2110 2120 2130 2140 2150 2160 QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF QDFRNRFNRF 2170 2180 2190 2200 2210 2220 FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV KAVEKGHWLI LDNANLCSPS 2230 2240 2250 2260 2270 2280 VLDRLNSLLE IDGSLLINEC SQEDGQPRVL KPHPNFRLFL TMDPKYGELS RAMRNRGVEI 2290 2300 2310 2320 2330 2340 YIDELHSRST AFDRLTLGFE LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC 2350 2360 2370 2380 2390 2400 IFAQVHDILL LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT 2410 2420 2430 2440 2450 2460 FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV SKYSDKIKSP 2470 2480 2490 2500 2510 2520 ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS AAAFNGRHLK NIPRIPIFCI 2530 2540 2550 2560 2570 2580 LYNILTVMSE NLKTESLFCG SNQYQYYWDL LVIVIAALET AVTKDEARLR VYKELIDSWI 2590 2600 2610 2620 2630 2640 ASVKSKSDIE ITPFLNINLE FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL 2650 2660 2670 2680 2690 2700 SEKFDKVRLL QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN 2710 2720 2730 2740 2750 2760 KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN KYNYPPIFDV 2770 2780 2790 2800 2810 2820 LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI KQSISDAELL LSSTIKCSPN 2830 2840 2850 2860 2870 2880 LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL KLTLKELCSL IEEKTASETR VTFAEYIFPA 2890 2900 2910 2920 2930 2940 LDLAESSKSL EELGEAWITF GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS 2950 2960 2970 2980 2990 3000 WRNVRKVISG DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ 3010 3020 3030 3040 3050 3060 IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY IYSINFGFDL 3070 3080 3090 3100 3110 3120 LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR FFKKGDMEDT SIEKVLMYFL 3130 3140 3150 3160 3170 3180 TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR RFRQEQEENE KSNMFKFNDN SDDYEADFRK 3190 3200 3210 3220 3230 3240 LFPDYEDTAL VTNEKDISSP ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL 3250 3260 3270 3280 3290 3300 SEDLKNTRIE ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET 3310 3320 3330 3340 3350 3360 VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY LAEWEKYASS 3370 3380 3390 3400 3410 3420 EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS IGKWWFYLYE SIVISNFVSE 3430 3440 3450 3460 3470 3480 KKETAPNATL LVSSLNLFFS KSTLGEFNAR LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK 3490 3500 3510 3520 3530 3540 FYYQFKPLID ERITNGKKSL EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR 3550 3560 3570 3580 3590 3600 DLLNGDAKTI IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN 3610 3620 3630 3640 3650 3660 IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK KRLAYLKTQK 3670 3680 3690 3700 3710 3720 SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP FNNEYLNSSD AFFFKILDLL 3730 3740 3750 3760 3770 3780 PKLRSAASNP SDDIPVAAIE RGMALAQSLM FSLITVRHPL SEFTNDYCKI NGMMLDLEHF 3790 3800 3810 3820 3830 3840 TCLKGDIVHS SLKANVDNVR LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL 3850 3860 3870 3880 3890 3900 SSFFVHFNSS RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG 3910 3920 3930 3940 3950 3960 PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS ASFKKVMVNV 3970 3980 3990 4000 4010 4020 KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL PVITRYYNAM TVVLERSRIY 4030 4040 4050 4060 4070 4080 YTNTSRGMYI LSTILHSLAK NGFCSPQPPS EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD 4090 4100 4110 4120 4130 4140 EDLTEDAQNE NKEQQDKDER DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL 4150 4160 4170 4180 4190 4200 DEEIDDLNED DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE 4210 4220 4230 4240 4250 4260 GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI ETLDLPEDMN 4270 4280 4290 4300 4310 4320 LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI ESDNENDEPG PEEDAGETET 4330 4340 4350 4360 4370 4380 ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ AMSDEEELKQ DAAMEENKEK GGEQNTEGLD 4390 4400 4410 4420 4430 4440 GVEEKADTED IDQEAAVQQD SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN 4450 4460 4470 4480 4490 4500 EESREEATAA LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE 4510 4520 4530 4540 4550 4560 TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE EEMLSDIDAH 4570 4580 4590 4600 4610 4620 DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS EIQSLIENIE DNPPDASASL 4630 4640 4650 4660 4670 4680 TPERSLEESR ELWHKSEIST ADLVSRLGEQ LRLILEPTLA TKLKGDYKTG KRLNMKRIIP 4690 4700 4710 4720 4730 4740 YIASQFRKDK IWLRRTKPSK RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA 4750 4760 4770 4780 4790 4800 GGLSIVKFGE NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM 4810 4820 4830 4840 4850 4860 VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES ILDMSQVNYI 4870 4880 4890 4900 4910 PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL RQYFTDLASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Identification of a 60S preribosomal particle that is closely linked to nuclear export." Bassler J., Grandi P., Gadal O., Lessmann T., Petfalski E., Tollervey D., Lechner J., Hurt E. Mol. Cell 8:517-529(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT.
[4]	"Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein." Garbarino J.E., Gibbons I.R. BMC Genomics 3:18-18(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[5]	"60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm." Nissan T.A., Bassler J., Petfalski E., Tollervey D., Hurt E. EMBO J. 21:5539-5547(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN PRE-60S RIBOSOMES, MASS SPECTROMETRY.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits." Galani K., Nissan T.A., Petfalski E., Tollervey D., Hurt E. J. Biol. Chem. 279:55411-55418(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]	"A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits." Nissan T.A., Galani K., Maco B., Tollervey D., Aebi U., Hurt E. Mol. Cell 15:295-301(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[9]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4388, MASS SPECTROMETRY.
[10]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-478; THR-1026; SER-2971; SER-4353 AND THR-4388, MASS SPECTROMETRY.
[11]	"Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits." Ulbrich C., Diepholz M., Bassler J., Kressler D., Pertschy B., Galani K., Bottcher B., Hurt E. Cell 138:911-922(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ASSOCIATION WITH THE PRE-60S PARTICLE, INTERACTION WITH RSA4.
[12]	"The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly." Bassler J., Kallas M., Pertschy B., Ulbrich C., Thoms M., Hurt E. Mol. Cell 38:712-721(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RSA4 AND YTM1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U53876 Genomic DNA. Translation: AAB67548.1. Z73278 Genomic DNA. Translation: CAA97671.1. BK006945 Genomic DNA. Translation: DAA09422.1.
PIR	S64942.
RefSeq	NP_013207.1. NM_001181993.1.
3D structure databases
ProteinModelPortal	Q12019.
SMR	Q12019. Positions 816-1195, 1743-1879.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6285N.
IntAct	Q12019. 42 interactions.
MINT	MINT-613312.
STRING	4932.YLR106C.
Proteomic databases
PaxDb	Q12019.
PeptideAtlas	Q12019.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR106C; YLR106C; YLR106C.
GeneID	850796.
KEGG	sce:YLR106C.
Organism-specific databases
CYGD	YLR106c.
SGD	S000004096. MDN1.
Phylogenomic databases
eggNOG	COG5271.
GeneTree	ENSGT00550000074802.
HOGENOM	HOG000164494.
KO	K14572.
OMA	ERVHKRL.
OrthoDB	EOG4XPTPX.
Gene expression databases
ArrayExpress	Q12019.
Genevestigator	Q12019.
GermOnline	YLR106C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR012099. Midasin. IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR002035. VWF_A. [Graphical view]
Pfam	PF07728. AAA_5. 8 hits. [Graphical view]
PIRSF	PIRSF010340. Midasin. 1 hit.
SMART	SM00382. AAA. 6 hits. SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	967011.

Entry information

Entry name

MDN1_YEAST

Accession

Primary (citable) accession number: Q12019
Secondary accession number(s): D6VYA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program