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Protein

Phosducin-like protein 2

Gene

PLP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for cell growth. Inhibits early G-protein signaling events following pheromone stimulation.1 Publication

Miscellaneous

Present with 7700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin binding Source: SGD
  • G-protein beta/gamma-subunit complex binding Source: SGD

GO - Biological processi

  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
  • protein folding Source: SGD
  • queuosine biosynthetic process Source: GO_Central

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processPheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-33768-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 2
Alternative name(s):
Viral IAP-associated factor 1 homolog
Gene namesi
Name:PLP2Imported
Synonyms:VIAF1Imported
Ordered Locus Names:YOR281C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR281C
SGDiS000005807 PLP2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637621 – 286Phosducin-like protein 2Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12017
PaxDbiQ12017
PRIDEiQ12017

PTM databases

iPTMnetiQ12017

Interactioni

Subunit structurei

Interacts with the G protein beta-gamma subunit complex (STE4-STE18 complex).1 Publication

GO - Molecular functioni

  • actin binding Source: SGD

Protein-protein interaction databases

BioGridi34669, 52 interactors
DIPiDIP-5004N
IntActiQ12017, 11 interactors
MINTiQ12017
STRINGi4932.YOR281C

Structurei

3D structure databases

ProteinModelPortaliQ12017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 286Thioredoxin foldBy similarityAdd BLAST191

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144176
HOGENOMiHOG000184445
InParanoidiQ12017
OMAiIKFCEIR
OrthoDBiEOG092C4BML

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q12017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEPMFQVQ VDESEDSEWN DILRAKGVIP ERAPSPTAKL EEALEEAIAK
60 70 80 90 100
QHENRLEDKD LSDLEELEDD EDEDFLEAYK IKRLNEIRKL QERSKFGEVF
110 120 130 140 150
HINKPEYNKE VTLASQGKKY EGAQTNDNGE EDDGGVYVFV HLSLQSKLQS
160 170 180 190 200
RILSHLFQSA ACKFREIKFV EIPANRAIEN YPESNCPTLI VYYRGEVIKN
210 220 230 240 250
MITLLELGGN NSKMEDFEDF MVKVGAVAEG DNRLIMNRDD EESREERKLH
260 270 280
YGEKKSIRSG IRGKFNVGIG GNDDGNINDD DDGFFD
Length:286
Mass (Da):32,793
Last modified:November 1, 1996 - v1
Checksum:i414A696FFBDBD833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110514 mRNA Translation: AAG21890.1
X89633 Genomic DNA Translation: CAA61786.1
Z75189 Genomic DNA Translation: CAA99507.1
AY558032 Genomic DNA Translation: AAS56358.1
BK006948 Genomic DNA Translation: DAA11046.1
PIRiS67183
RefSeqiNP_014924.3, NM_001183700.3

Genome annotation databases

EnsemblFungiiYOR281C; YOR281C; YOR281C
GeneIDi854456
KEGGisce:YOR281C

Similar proteinsi

Entry informationi

Entry nameiPLP2_YEAST
AccessioniPrimary (citable) accession number: Q12017
Secondary accession number(s): D6W2Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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