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Protein

Phosphoglycerate mutase 2

Gene

GPM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be non-functional.

Miscellaneous

Present with 2020 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (TDH1), Glyceraldehyde-3-phosphate dehydrogenase 2 (TDH2), Glyceraldehyde-3-phosphate dehydrogenase 3 (TDH3)
  2. Phosphoglycerate kinase (PGK1)
  3. Phosphoglycerate mutase 2 (GPM2), Phosphoglycerate mutase 3 (GPM3), Phosphoglycerate mutase 1 (GPM1)
  4. Enolase 2 (ENO2), Enolase-related protein 2 (ERR2), Enolase-related protein 1 (ERR1), Enolase-related protein 3 (ERR3), Enolase 1 (ENO1)
  5. Pyruvate kinase 2 (PYK2), Pyruvate kinase 1 (CDC19)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17Tele-phosphohistidine intermediateBy similarity1
Binding sitei73SubstrateBy similarity1
Active sitei126Proton donor/acceptorBy similarity1
Binding sitei137SubstrateBy similarity1
Sitei242Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

BioCyciYEAST:G3O-29450-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 2 (EC:5.4.2.11)
Short name:
PGAM 2
Alternative name(s):
BPG-dependent PGAM 2
MPGM 2
Phosphoglyceromutase 2
Gene namesi
Name:GPM2
Ordered Locus Names:YDL021W
ORF Names:D2835
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL021W
SGDiS000002179 GPM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798401 – 311Phosphoglycerate mutase 2Add BLAST311

Proteomic databases

MaxQBiQ12008
PaxDbiQ12008
PRIDEiQ12008
TopDownProteomicsiQ12008

PTM databases

iPTMnetiQ12008

Interactioni

Protein-protein interaction databases

BioGridi32034, 42 interactors
IntActiQ12008, 4 interactors
MINTiQ12008
STRINGi4932.YDL021W

Structurei

3D structure databases

ProteinModelPortaliQ12008
SMRiQ12008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 23Substrate bindingBy similarity8
Regioni29 – 30Substrate bindingBy similarity2
Regioni126 – 129Substrate bindingBy similarity4
Regioni153 – 154Substrate bindingBy similarity2
Regioni243 – 244Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075884
HOGENOMiHOG000221682
InParanoidiQ12008
KOiK01834
OMAiDYEGKPP
OrthoDBiEOG092C3A2P

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 2 hits
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q12008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASTPSNVM TLFLLRHGQS ELNHENIFCG WIDAKLTEKG KEQARHSAEL
60 70 80 90 100
IEQYCKANNL RLPQIGYTSR LIRTQQTIET MCEEFKLKPQ LQVVYDFNKI
110 120 130 140 150
KLGDEFGSDD KDNMKIPILQ TWRLNERHYG SWQGQRKPNV LKEYGKDKYM
160 170 180 190 200
FIRRDYEGKP PPVDLDREMI QQENEKGSST GYEFKEPNRQ IKYELECSNH
210 220 230 240 250
DIVLPDSESL REVVYRLNPF LQNVILKLAN QYDESSCLIV GHGSSVRSLL
260 270 280 290 300
KILEGISDDD IKNVDIPNGI PLVVELDKNN GLKFIRKFYL DPESAKINAE
310
KVRNEGFIKN P
Length:311
Mass (Da):36,073
Last modified:November 1, 1997 - v1
Checksum:i1E53ECAAF06C932C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48432 Genomic DNA Translation: CAA88338.1
Z74069 Genomic DNA Translation: CAA98580.1
AY692876 Genomic DNA Translation: AAT92895.1
BK006938 Genomic DNA Translation: DAA11829.1
PIRiS52498
RefSeqiNP_010263.1, NM_001180080.1

Genome annotation databases

EnsemblFungiiYDL021W; YDL021W; YDL021W
GeneIDi851541
KEGGisce:YDL021W

Similar proteinsi

Entry informationi

Entry nameiPMG2_YEAST
AccessioniPrimary (citable) accession number: Q12008
Secondary accession number(s): D6VRW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health