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Protein

Serine/threonine-protein kinase ENV7

Gene

ENV7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in vacuolar processing and morphology.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69ATPPROSITE-ProRule annotation1
Active sitei215Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • protein phosphorylation Source: GO_Central
  • regulation of vacuole fusion, non-autophagic Source: SGD
  • vacuolar protein processing Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ENV7 (EC:2.7.11.1)
Alternative name(s):
Late endosome and vacuole interface protein 7
Gene namesi
Name:ENV7
Ordered Locus Names:YPL236C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL236C.
SGDiS000006157. ENV7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

Leads to internal accumulation of precursor CPY.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002559771 – 364Serine/threonine-protein kinase ENV7Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi13S-palmitoyl cysteine1 Publication1
Lipidationi14S-palmitoyl cysteine1 Publication1
Lipidationi15S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ12003.
PRIDEiQ12003.

PTM databases

SwissPalmiQ12003.

Interactioni

Protein-protein interaction databases

BioGridi35926. 73 interactors.
DIPiDIP-6626N.
IntActiQ12003. 2 interactors.
MINTiMINT-659141.
STRINGi4932.YPL236C.

Structurei

3D structure databases

ProteinModelPortaliQ12003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 364Protein kinasePROSITE-ProRule annotationAdd BLAST335

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075037.
HOGENOMiHOG000157694.
InParanoidiQ12003.
KOiK08856.
OMAiSFVYLAQ.
OrthoDBiEOG092C3QZI.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PfamiView protein in Pfam
PF00069. Pkinase. 2 hits.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISIVLELFQ NLCCCRGFSD ATIRVNDKRY RIQRLLGEGG MSFVYLVQLS
60 70 80 90 100
KNSLIIDNGI ATPELYALKK IICPSVESIS NGMREIENYK RFQSPYVIKS
110 120 130 140 150
IDSQVMQEKD GSKTIYIVLP YYSLGSLQDS INRRLLEGTF VSEAECVRIM
160 170 180 190 200
LGVTRGLLCL HDPASRQDNA TSRVNVDAVS MTYSDETAML LEDTPLEMDM
210 220 230 240 250
LSSNSAGSIA YAHRDITPSN ILFSSDGLPV IGDLGSCSQA DITIENRHQL
260 270 280 290 300
SELQEWVNDN CTLPYTPPEL LNLKLNQVLS SKVDIWSLGC TFYTLMFGIS
310 320 330 340 350
PFEREEQIHG ASLTYAINTG KYSFPRNSRF SEGLLSVIKK CIQVDPIQRP
360
TTSQLLNLLQ DLDT
Length:364
Mass (Da):40,749
Last modified:November 1, 1996 - v1
Checksum:i3A7439E4077BAD20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67751 Genomic DNA. Translation: CAA91608.1.
Z73591 Genomic DNA. Translation: CAA97953.1.
Z73592 Genomic DNA. Translation: CAA97954.1.
BK006949 Genomic DNA. Translation: DAA11200.1.
PIRiS61028.
RefSeqiNP_015088.1. NM_001184050.1.

Genome annotation databases

EnsemblFungiiYPL236C; YPL236C; YPL236C.
GeneIDi855840.
KEGGisce:YPL236C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiENV7_YEAST
AccessioniPrimary (citable) accession number: Q12003
Secondary accession number(s): D6W3D4, Q7LGU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names