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Protein

Translation machinery-associated protein 46

Gene

TMA46

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 114C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri158 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 46
Alternative name(s):
DRG family-regulatory protein 1
Gene namesi
Name:TMA46
Synonyms:DFRP1
Ordered Locus Names:YOR091W
ORF Names:YOR3160w
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR091W.
SGDiS000005617. TMA46.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376381 – 345Translation machinery-associated protein 46Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12000.
PRIDEiQ12000.

PTM databases

iPTMnetiQ12000.

Interactioni

Subunit structurei

Interacts with RBG1 and with translating ribosomes.2 Publications

Protein-protein interaction databases

BioGridi34489. 21 interactors.
IntActiQ12000. 5 interactors.
MINTiMINT-1326214.

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi222 – 227Combined sources6
Helixi230 – 232Combined sources3
Helixi235 – 237Combined sources3
Helixi243 – 265Combined sources23
Helixi272 – 281Combined sources10
Helixi306 – 317Combined sources12
Helixi320 – 322Combined sources3
Beta strandi323 – 325Combined sources3
Beta strandi329 – 331Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67C/D205-345[»]
ProteinModelPortaliQ12000.
SMRiQ12000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H15/TMA46 family.Curated
Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 114C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri158 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000015818.
HOGENOMiHOG000177574.
InParanoidiQ12000.
OMAiITMENFA.
OrthoDBiEOG092C4PJG.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR032378. ZC3H15/TMA46_C.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKKGKQAQ AAGKKKDNVD KTFGMKNKNR STKVQKYIKQ VQSQSDPKKE
60 70 80 90 100
EMRLKKLEEK KRREAEEAER RALFNPVADQ RVRAGVDPKS MVCALFKLGN
110 120 130 140 150
CNKGAKCKFS HDLNVGRRME KKDLYQDTRS EKENDTMDNW DEEKLRKVIL
160 170 180 190 200
SKHGNPKTTT DKVCKYFIEA VENGKYGWFW ICPNGGDKCM YRHSLPEGFV
210 220 230 240 250
LKTNEQKRLE RESLEKQPKI TLEEFIETER GKLDKSKLTP ITIANFAQWK
260 270 280 290 300
KDHVIAKINA EKKLSSKRKP TGREIILKMS AENKSFETDN ADMPDDVTQG
310 320 330 340
SAWDLTEFTD ALKKADHQDD GGIKDYGDGS NPTFDIKKAN SATLA
Length:345
Mass (Da):39,514
Last modified:May 30, 2006 - v2
Checksum:iF1D2C384881C4DAA
GO

Sequence cautioni

The sequence CAA64012 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA99288 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64012.1. Different initiation.
Z74999 Genomic DNA. Translation: CAA99288.1. Different initiation.
BK006948 Genomic DNA. Translation: DAA10868.1.
PIRiS61651.
RefSeqiNP_014734.2. NM_001183510.1.

Genome annotation databases

EnsemblFungiiYOR091W; YOR091W; YOR091W.
GeneIDi854258.
KEGGisce:YOR091W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64012.1. Different initiation.
Z74999 Genomic DNA. Translation: CAA99288.1. Different initiation.
BK006948 Genomic DNA. Translation: DAA10868.1.
PIRiS61651.
RefSeqiNP_014734.2. NM_001183510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A9AX-ray2.67C/D205-345[»]
ProteinModelPortaliQ12000.
SMRiQ12000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34489. 21 interactors.
IntActiQ12000. 5 interactors.
MINTiMINT-1326214.

PTM databases

iPTMnetiQ12000.

Proteomic databases

MaxQBiQ12000.
PRIDEiQ12000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR091W; YOR091W; YOR091W.
GeneIDi854258.
KEGGisce:YOR091W.

Organism-specific databases

EuPathDBiFungiDB:YOR091W.
SGDiS000005617. TMA46.

Phylogenomic databases

GeneTreeiENSGT00390000015818.
HOGENOMiHOG000177574.
InParanoidiQ12000.
OMAiITMENFA.
OrthoDBiEOG092C4PJG.

Enzyme and pathway databases

BioCyciYEAST:G3O-33625-MONOMER.

Miscellaneous databases

PROiQ12000.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR032378. ZC3H15/TMA46_C.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMA46_YEAST
AccessioniPrimary (citable) accession number: Q12000
Secondary accession number(s): D6W2F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4220 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.