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Q11YZ8 (Q11YZ8_CYTH3) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384
Ordered Locus Names:CHU_0074
OrganismCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP] EMBL ABG57368.1
Taxonomic identifier269798 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm By similarity HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis HAMAP MF_00384
   Cellular componentCytoplasm HAMAP MF_00384
   LigandATP-binding HAMAP MF_00384
Nucleotide-binding
   Molecular functionKinase HAMAP MF_00384 EMBL ABG57368.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding91 – 10111ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
Q11YZ8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: BFB5A1A4577A61CC

FASTA30932,434
        10         20         30         40         50         60 
MKDSIKVFAP ATVANVSCGF DVLGFAVDNP GDEVLLRLSD KKGVRITSIT GDDGRLPKDA 

        70         80         90        100        110        120 
EKNTVSISIL RYLETLGIEQ GIEIELTKKM PLGSGLGSSA ASTVAGVYAI NQLLGNKMEV 

       130        140        150        160        170        180 
KDLLPFAMEG EFLACGSAHA DNVAPCLYGG FVLVRSYDPL DVVKLPVPAN LYATIIHPHV 

       190        200        210        220        230        240 
EVQTKDARNI LPKQIALSQA VAQWGNVGGL VAGLLMNDTS LIGRSMQDHI VEPARSVLIP 

       250        260        270        280        290        300 
GFDDVKKAAL DAGALGCSIS GSGPSIFALS TSQEAAQKIG QAMKKGFDAI NIGSDVYVST 


VNQQGPKVI

« Hide

References

[1]"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii."
Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J.
Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000383 Genomic DNA. Translation: ABG57368.1.
RefSeqYP_676708.1. NC_008255.1.

3D structure databases

ProteinModelPortalQ11YZ8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11YZ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4186393.
GenomeReviewsGene locus CHU_0074 in contig CP000383_GR.
KEGGchu:CHU_0074.
NMPDRfig|269798.12.peg.68.
PATRIC21590959. VBICytHut34013_0069.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHBG646290.
OMAGSAHADN.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ11YZ8_CYTH3
AccessionPrimary (citable) accession number: Q11YZ8
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info