Reviewed, UniProtKB/Swiss-Prot Q11XA9 (RLMF_CYTH3)

Names and origin

Protein names

Recommended name:
    Ribosomal RNA large subunit methyltransferase F
    EC=2.1.1.48
Alternative name(s):
    23S rRNA mA1618 methyltransferase
    rRNA adenine N-6-methyltransferase

Gene names

Name:	rlmF
Ordered Locus Names:	CHU_0670

Organism

Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP]

Taxonomic identifier

269798 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Sphingobacteria › Sphingobacteriales › Flexibacteraceae › Cytophaga

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically methylates the adenine in position 1618 of 23S rRNA By similarity.
Catalytic activity	S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine. HAMAP MF_01848
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the methyltransferase superfamily. METT10D/rlmF family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA modification Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rRNA (adenine-N6-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Ribosomal RNA large subunit methyltransferase F HAMAP MF_01848		PRO_0000349900

Sequences

	Sequence		Length	Mass (Da)
	Q11XA9-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 31F267FEE478B215	FASTA	322	35,944
	10 20 30 40 50 60 MAEKNKKEHP VTKDRLHPRN KHRERYDFDA LIATTPELAQ YVTLNIYNDQ SIDFFNPAAV 70 80 90 100 110 120 LCLNQALLKH YYGIDEWNIP EGYLCPPIPG RADYIHNIAA LLGTSANDVI PVGPAIKCLD 130 140 150 160 170 180 IGVGANCVYP IIGNNEYGWS FVGADVDPVS VASAKNIVDK NKVLQGNVEI RLQNHPLDIF 190 200 210 220 230 240 YGIIGEGERF DVTICNPPFH ASAEDAAAGT LRKLSNLQHK KVTKANLNFG GQHNELWCEG 250 260 270 280 290 300 GESAFVREMI LESKKFAASC LWFSTLISKQ TNLQKAYDQL EVLAPFDVRT IPMGQGNKSS 310 320 RLIAWTFQSK EAQAKWVSAR WK

References

[1]

"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii." Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J. Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000383 Genomic DNA. Translation: ABG57957.1.
RefSeq	YP_677297.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4185673.
GenomeReviews	Gene locus CHU_0670 in contig CP000383_GR.
KEGG	chu:CHU_0670.
NMPDR	fig|269798.12.peg.637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q11XA9.
OMA	Q11XA9. LNFGGQN.
Family and domain databases
HAMAP	MF_01848. [Tree]
InterPro	IPR016909. S-AdoMet-dep_MeTrfase_YbiN_prd. IPR010286. SAM-Mtase_prd. [Graphical view]
PANTHER	PTHR13393. DUF890. 1 hit.
Pfam	PF05971. Methyltransf_10. 1 hit. [Graphical view]
PIRSF	PIRSF029038. Mtase_YbiN_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMF_CYTH3

Accession

Primary (citable) accession number: Q11XA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)