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Reviewed, UniProtKB/Swiss-Prot Q11X05 (DCUP_CYTH3)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: CHU_0774
OrganismCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP]
Taxonomic identifier269798 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Sphingobacteria › Sphingobacteriales › Flexibacteraceae › Cytophaga

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Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325635

Regions

Region26 – 305Substrate binding By similarity

Sites

Binding site761Substrate By similarity
Binding site1531Substrate By similarity
Binding site2081Substrate By similarity
Binding site3191Substrate By similarity
Site761Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q11X05-1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 063E4CE96C62932F

FASTA34438,377
        10         20         30         40         50         60 
MQYQNDLILR AARGEAVERT PVWLMRQAGR ILPEYRAVRE KLSGFIELCT TPALAAEVTI 

        70         80         90        100        110        120 
QPVDILGVDA AIIFSDILVI PEAMGLPYEM QESKGPFFPK VITSAADIDA LLATDAADHL 

       130        140        150        160        170        180 
TYVYDAIELA VKELNGRVPL IGFAGAPFTI LAYMIEGQGS KTFSKARRFL YTEPVLAHRL 

       190        200        210        220        230        240 
LEKITLATIA YLKRQVQAGA AMYQIFDSWA GVLPPDQYRE FSLRYIKQIC EAVPQVPRTV 

       250        260        270        280        290        300 
FSKGAFFVRE DFNNFPCETV GLDWNMDIGE SKKIIGPHKT LQGNMDPCAL YLSEEQIRVK 

       310        320        330        340 
AKEMLDAFGT QSHIANLGHG LYPDTDKTKV KCFVDAVKEF GVKK

« Hide

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References

[1]"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii."
Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J.
Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000383 Genomic DNA. Translation: ABG58061.1.
RefSeqYP_677401.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4184144.
GenomeReviewsGene locus CHU_0774 in contig CP000383_GR.
KEGGchu:CHU_0774.
NMPDRfig|269798.12.peg.736.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ11X05.
OMAQ11X05. VFTKGGG.

Enzyme and pathway databases

BioCycCHUT269798:CHU_0774-MON.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_CYTH3
AccessionPrimary (citable) accession number: Q11X05
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 22, 2006
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents