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Q11X05 (DCUP_CYTH3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:CHU_0774
OrganismCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP]
Taxonomic identifier269798 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325635

Regions

Region26 – 305Substrate binding By similarity

Sites

Binding site761Substrate By similarity
Binding site1531Substrate By similarity
Binding site2081Substrate By similarity
Binding site3191Substrate By similarity
Site761Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11X05 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 063E4CE96C62932F

FASTA34438,377
        10         20         30         40         50         60 
MQYQNDLILR AARGEAVERT PVWLMRQAGR ILPEYRAVRE KLSGFIELCT TPALAAEVTI 

        70         80         90        100        110        120 
QPVDILGVDA AIIFSDILVI PEAMGLPYEM QESKGPFFPK VITSAADIDA LLATDAADHL 

       130        140        150        160        170        180 
TYVYDAIELA VKELNGRVPL IGFAGAPFTI LAYMIEGQGS KTFSKARRFL YTEPVLAHRL 

       190        200        210        220        230        240 
LEKITLATIA YLKRQVQAGA AMYQIFDSWA GVLPPDQYRE FSLRYIKQIC EAVPQVPRTV 

       250        260        270        280        290        300 
FSKGAFFVRE DFNNFPCETV GLDWNMDIGE SKKIIGPHKT LQGNMDPCAL YLSEEQIRVK 

       310        320        330        340 
AKEMLDAFGT QSHIANLGHG LYPDTDKTKV KCFVDAVKEF GVKK

« Hide

References

[1]"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii."
Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J.
Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33406 / NCIMB 9469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000383 Genomic DNA. Translation: ABG58061.1.
RefSeqYP_677401.1. NC_008255.1.

3D structure databases

ProteinModelPortalQ11X05.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11X05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4184144.
GenomeReviewsGene locus CHU_0774 in contig CP000383_GR.
KEGGchu:CHU_0774.
NMPDRfig|269798.12.peg.736.
PATRIC21592387. VBICytHut34013_0770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBCLSK2530560.

Enzyme and pathway databases

BioCycCHUT269798:CHU_0774-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CYTH3
AccessionPrimary (citable) accession number: Q11X05
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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