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Protein

D-alanine--D-alanine ligase

Gene

ddlA

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:CHU_0924Imported
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)Imported
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
Proteomesi
  • UP000001822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_0924.

Family & Domainsi

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000121145.
KOiK01921.
OMAiVHTIPKD.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 4 hits.
PF01820. Dala_Dala_lig_N. 2 hits.
SUPFAMiSSF52440. SSF52440. 2 hits.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 2 hits.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11WL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGIIFGGQ SREREISFAG GRTVYDNLNK DIFTTVPIFV DSLGQFILLD
60 70 80 90 100
WQYIYKGTIR DFYPPFEFLP KSIHGFQVYV ESLGDLPKEE RDAMIQKVGR
110 120 130 140 150
KIEPSDLKEL IDFAFLALHG PYGEDGAIQG MLDWNNIPYS GSGILPSAIG
160 170 180 190 200
INKYIQKKLV AQASFNGPNY VTYKKSTWLK GADTKALLAH FESSVGFPFV
210 220 230 240 250
VKAPSQGSSI GITVISERNE EKLKQALNRS FFLQEITAAD WNTKTEHAKI
260 270 280 290 300
KWVATLTDIR DGIGMPVNDV LQGKTIYHPE ELLAHLNQSL SSKERVLLES
310 320 330 340 350
LDNEEEIIIE SFIKGQEFSC IVIQDEDGNP IALPPTGIVK GNDFFDYRSK
360 370 380 390 400
YLPGMSRKIT PIDIPGEQVE LIRSECCRLY STLQFNVYAR IDGFISPEGE
410 420 430 440 450
VFLNDPNTTS GMMPSSFFFH QAAEIGLNPS QFLTYIIRTS IQERIKDGKR
460 470 480 490 500
SLRYKQLLAT LDQAISSEKN SSKEKIKIAV VMGGYSSERH ISVESGRNIF
510 520 530 540 550
EKLSSSTKYQ PLPVFLTGSD EQHRLFILPI NILLKDNADD IREKVINFKG
560 570 580 590 600
HHPIIEHIAK ETESISSRYV SNAIKDPKEI SYKELSELVD GVFIALHGRP
610 620 630 640 650
GEDGSMQKEL EKYQLPYNGS GIQSSQITIN KFETNRILRE HGISVANHRM
660 670 680 690 700
VYKQEWLDAG EKLLSEIESG FIYPIIAKPS DDGCSSAVKK IKNRDELRAY
710 720 730 740 750
TRLMFGEEAI QGSVSSSVLG LKYNEEFPQK DYFLIEDLVS KGNAKHFLEV
760 770 780 790 800
TGGLMTRFND KGNVEYEIFE PSESLATGDV LSLEEKFLAG EGQNITPARY
810 820 830 840 850
TTNKADYEQV ASEVRATLKR VAEVLNIQGY ARIDAFVRVF ENNRSETIII
860 870 880 890
EVNSLPGMTP ATCIFHQTAI NGYKPYDFID NILTFGIERE KKKLAKI
Length:897
Mass (Da):101,061
Last modified:August 22, 2006 - v1
Checksum:i74C2C50264BFB669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG58203.1.
RefSeqiWP_011584318.1. NZ_FPJX01000005.1.

Genome annotation databases

EnsemblBacteriaiABG58203; ABG58203; CHU_0924.
KEGGichu:CHU_0924.

Similar proteinsi

Entry informationi

Entry nameiQ11WL3_CYTH3
AccessioniPrimary (citable) accession number: Q11WL3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported