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Q11WJ0

- UPPP_CYTH3

UniProt

Q11WJ0 - UPPP_CYTH3

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, CHU_0949
Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:CHU_0949
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
ProteomesiUP000001822: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei41 – 6121Helical; Reviewed predictionAdd
BLAST
Transmembranei69 – 8921Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Transmembranei132 – 15221Helical; Reviewed predictionAdd
BLAST
Transmembranei172 – 19221Helical; Reviewed predictionAdd
BLAST
Transmembranei208 – 22821Helical; Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Undecaprenyl-diphosphataseUniRule annotationPRO_0000290704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_0949.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiPIVFDIY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11WJ0-1 [UniParc]FASTAAdd to Basket

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MTWLESIILA IVEGVTEFLP VSSTGHMIIT SALMGIKSDP FTKVFEVAIQ    50
FGAILSVVVL YFKRFFKSCD FYFKLFVAFI PTAIVGLLLK KHIDTWLENV 100
WVVASTLLVG GIVLLFVDKW FQKNETEGEE EVSYQTGFLI GCFQCLAMIP 150
GVSRSAATII GGLTQKLTRK AAAEFSFFLA VPTMFAATAK SLYDEKELIL 200
ESTDKIPLLL LGNVVAFIVA MLAIKFFINI LTKYGFKAFG YYRIALGALL 250
LILLAMHVDL QVV 263
Length:263
Mass (Da):29,183
Last modified:August 22, 2006 - v1
Checksum:iDA643E5CE23E3C26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000383 Genomic DNA. Translation: ABG58226.1.
RefSeqiWP_011584341.1. NC_008255.1.
YP_677566.1. NC_008255.1.

Genome annotation databases

EnsemblBacteriaiABG58226; ABG58226; CHU_0949.
GeneIDi4183647.
KEGGichu:CHU_0949.
PATRICi21592747. VBICytHut34013_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000383 Genomic DNA. Translation: ABG58226.1 .
RefSeqi WP_011584341.1. NC_008255.1.
YP_677566.1. NC_008255.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269798.CHU_0949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG58226 ; ABG58226 ; CHU_0949 .
GeneIDi 4183647.
KEGGi chu:CHU_0949.
PATRICi 21592747. VBICytHut34013_0949.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi PIVFDIY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CHUT269798:GJ83-950-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33406 / NCIMB 9469.

Entry informationi

Entry nameiUPPP_CYTH3
AccessioniPrimary (citable) accession number: Q11WJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi