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Q11WJ0

- UPPP_CYTH3

UniProt

Q11WJ0 - UPPP_CYTH3

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCHUT269798:GJ83-950-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA
    Ordered Locus Names:CHU_0949
    OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
    Taxonomic identifieri269798 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
    ProteomesiUP000001822: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Undecaprenyl-diphosphatasePRO_0000290704Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269798.CHU_0949.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei69 – 8921HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei132 – 15221HelicalUniRule annotationAdd
    BLAST
    Transmembranei172 – 19221HelicalUniRule annotationAdd
    BLAST
    Transmembranei208 – 22821HelicalUniRule annotationAdd
    BLAST
    Transmembranei238 – 25821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiPIVFDIY.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q11WJ0-1 [UniParc]FASTAAdd to Basket

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    MTWLESIILA IVEGVTEFLP VSSTGHMIIT SALMGIKSDP FTKVFEVAIQ    50
    FGAILSVVVL YFKRFFKSCD FYFKLFVAFI PTAIVGLLLK KHIDTWLENV 100
    WVVASTLLVG GIVLLFVDKW FQKNETEGEE EVSYQTGFLI GCFQCLAMIP 150
    GVSRSAATII GGLTQKLTRK AAAEFSFFLA VPTMFAATAK SLYDEKELIL 200
    ESTDKIPLLL LGNVVAFIVA MLAIKFFINI LTKYGFKAFG YYRIALGALL 250
    LILLAMHVDL QVV 263
    Length:263
    Mass (Da):29,183
    Last modified:August 22, 2006 - v1
    Checksum:iDA643E5CE23E3C26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG58226.1.
    RefSeqiWP_011584341.1. NC_008255.1.
    YP_677566.1. NC_008255.1.

    Genome annotation databases

    EnsemblBacteriaiABG58226; ABG58226; CHU_0949.
    GeneIDi4183647.
    KEGGichu:CHU_0949.
    PATRICi21592747. VBICytHut34013_0949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG58226.1 .
    RefSeqi WP_011584341.1. NC_008255.1.
    YP_677566.1. NC_008255.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269798.CHU_0949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG58226 ; ABG58226 ; CHU_0949 .
    GeneIDi 4183647.
    KEGGi chu:CHU_0949.
    PATRICi 21592747. VBICytHut34013_0949.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi PIVFDIY.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci CHUT269798:GJ83-950-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33406 / NCIMB 9469.

    Entry informationi

    Entry nameiUPPP_CYTH3
    AccessioniPrimary (citable) accession number: Q11WJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3