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Q11VZ3 (ILVC_CYTH3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:CHU_1149
OrganismCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP]
Taxonomic identifier269798 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190944

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q11VZ3 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 194FC1E4C601AC4C

FASTA49254,293
        10         20         30         40         50         60 
MANYFNTLSL REKLDQLGVC EFMDRSEFSD GVAALKGKKI VIVGCGAQGL NQGLNLRDSG 

        70         80         90        100        110        120 
LDVSYTLRKE AIDSKRQSFL NASENGFKVG TYEELIPTAD LVINLTPDKQ HTAVVSAVMP 

       130        140        150        160        170        180 
LMKKGSTLSY SHGFNIVEEG MQIRKDITVI MVAPKSPGSE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPEGKGWDY AKAYCVGTGG DRAGVLKSSF VAEVKSDLMG EQTILCGLLQ TGSILCFDKM 

       250        260        270        280        290        300 
VEKGIDKGYA SKLIQYGWEV ITESLKHGGI SGMMDRLSNP AKIKAFQVSE ELKDIMRPLF 

       310        320        330        340        350        360 
RKHQDDIISG EFSRIMMEDW ANGDKNLLTW RAATGETAFE KTPAGDVKIA EQEYYDNGLL 

       370        380        390        400        410        420 
MVAMVRAGVE LAFETMTESG IIDESAYYES LHETPLIANT IARKKLFEMN RVISDTAEYG 

       430        440        450        460        470        480 
CYLFDHACKP LLANFMKTVD TDIIGKNFNA GKDNGVDNQM LIAVNEVLRS HPIEIVGAEL 

       490 
REAMTEMKAI VS

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References

[1]"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii."
Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J.
Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33406 / NCIMB 9469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000383 Genomic DNA. Translation: ABG58424.1.
RefSeqYP_677763.1. NC_008255.1.

3D structure databases

ProteinModelPortalQ11VZ3.
SMRQ11VZ3. Positions 3-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11VZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4184521.
GenomeReviewsGene locus CHU_1149 in contig CP000383_GR.
KEGGchu:CHU_1149.
NMPDRfig|269798.12.peg.1102.
PATRIC21593157. VBICytHut34013_1152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycCHUT269798:CHU_1149-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_CYTH3
AccessionPrimary (citable) accession number: Q11VZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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