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Q11VK7

- SYL_CYTH3

UniProt

Q11VK7 - SYL_CYTH3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei698 – 6981ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHUT269798:GJ83-1285-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CHU_1287
    OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
    Taxonomic identifieri269798 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
    ProteomesiUP000001822: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 921921Leucine--tRNA ligasePRO_1000074831Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269798.CHU_1287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11VK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5212"HIGH" regionAdd
    BLAST
    Motifi695 – 6995"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q11VK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADYHFGEVE NKWQSKWNAE KTFKALENSS KPKYFVLDMF PYPSGSGLHV    50
    GHPLGYIASD IMARYKRIKG YNVLHPMGFD SFGLPAEQYA VQTGQHPAIT 100
    TEQNIARYIE QLNKIGFSFD WDREIRTSDP AYYKWTQWIF IQLFNHWYNK 150
    ASDKAEPITN LVKQFETAGN AGINAACDED AVTFTAADWK SYSEKQQSDT 200
    LLKYRLTYLS ETMVNWCPGL GTVLANEEVK DGLSERGGFP VERKKMKQWS 250
    MRITAYADRL LKGLDTIDWP EAMKEMQRYW IGKSLGAMLT FKVVDKDMEL 300
    TVFTTRIDTT FGVTYVSIAP EHEWIGALTS PEQKAAVEEY VTKAKNRSER 350
    DRMSDVKTVS GCFTGSYVTN PFNNEKIPVW IADYVLAGYG TGVVMAVPSS 400
    DERDYKFASF YKLPIISVQE GAHTDITKED FDPKAGTMIN SGFLNGLTVK 450
    QAIPEAIKFI EEKKIGFAKI NFKMRDSIFG RQRYWGEPIP VSYKNDIPYV 500
    LNESELPLAL PAIDEYKPTE TGEPPLARNK AFADKGYELS TMPGWAGSSW 550
    YFMRYMDPQN KTAVAAADKI NYWGQVDLYM GGAEHATGHL LYSRFWNKFL 600
    FDMGITPNDE PFAKLINQGM IQGVSKFAYR INGTNKFVSA GLKKEYDTTP 650
    IHVDVSIVHN DVLDTEAFKK WRPDFASAEF ILENNTYVCG SEVEKMSKSK 700
    FNVVNPDDIV NKYGADTLRM YEMFLGPLEQ SKPWNTNGIE GVYKFLNRFW 750
    RLFHDTAGNF AVSDAQPTAE ELKVLHKTLK RVEEDIERFS FNTPVSTFMI 800
    CVNELGSLKC NKRTILEPLT IALSPLAPHI AEELWSLLGH TTSVSTATYP 850
    AWDEKFLVES NHEYPISING KMRAKLNLPV DMPAAEVEQQ VLANEVVQKW 900
    LEGKAPKKII VIPNKIVNVV M 921
    Length:921
    Mass (Da):104,655
    Last modified:August 22, 2006 - v1
    Checksum:iFEE623E5B6E57BFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG58559.1.
    RefSeqiWP_011584674.1. NC_008255.1.
    YP_677899.1. NC_008255.1.

    Genome annotation databases

    EnsemblBacteriaiABG58559; ABG58559; CHU_1287.
    GeneIDi4185986.
    KEGGichu:CHU_1287.
    PATRICi21593423. VBICytHut34013_1285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG58559.1 .
    RefSeqi WP_011584674.1. NC_008255.1.
    YP_677899.1. NC_008255.1.

    3D structure databases

    ProteinModelPortali Q11VK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269798.CHU_1287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG58559 ; ABG58559 ; CHU_1287 .
    GeneIDi 4185986.
    KEGGi chu:CHU_1287.
    PATRICi 21593423. VBICytHut34013_1285.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CHUT269798:GJ83-1285-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33406 / NCIMB 9469.

    Entry informationi

    Entry nameiSYL_CYTH3
    AccessioniPrimary (citable) accession number: Q11VK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3