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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei698 – 6981ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-1285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CHU_1287
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
ProteomesiUP000001822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 921921Leucine--tRNA ligasePRO_1000074831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_1287.

Structurei

3D structure databases

ProteinModelPortaliQ11VK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi695 – 6995"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11VK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYHFGEVE NKWQSKWNAE KTFKALENSS KPKYFVLDMF PYPSGSGLHV
60 70 80 90 100
GHPLGYIASD IMARYKRIKG YNVLHPMGFD SFGLPAEQYA VQTGQHPAIT
110 120 130 140 150
TEQNIARYIE QLNKIGFSFD WDREIRTSDP AYYKWTQWIF IQLFNHWYNK
160 170 180 190 200
ASDKAEPITN LVKQFETAGN AGINAACDED AVTFTAADWK SYSEKQQSDT
210 220 230 240 250
LLKYRLTYLS ETMVNWCPGL GTVLANEEVK DGLSERGGFP VERKKMKQWS
260 270 280 290 300
MRITAYADRL LKGLDTIDWP EAMKEMQRYW IGKSLGAMLT FKVVDKDMEL
310 320 330 340 350
TVFTTRIDTT FGVTYVSIAP EHEWIGALTS PEQKAAVEEY VTKAKNRSER
360 370 380 390 400
DRMSDVKTVS GCFTGSYVTN PFNNEKIPVW IADYVLAGYG TGVVMAVPSS
410 420 430 440 450
DERDYKFASF YKLPIISVQE GAHTDITKED FDPKAGTMIN SGFLNGLTVK
460 470 480 490 500
QAIPEAIKFI EEKKIGFAKI NFKMRDSIFG RQRYWGEPIP VSYKNDIPYV
510 520 530 540 550
LNESELPLAL PAIDEYKPTE TGEPPLARNK AFADKGYELS TMPGWAGSSW
560 570 580 590 600
YFMRYMDPQN KTAVAAADKI NYWGQVDLYM GGAEHATGHL LYSRFWNKFL
610 620 630 640 650
FDMGITPNDE PFAKLINQGM IQGVSKFAYR INGTNKFVSA GLKKEYDTTP
660 670 680 690 700
IHVDVSIVHN DVLDTEAFKK WRPDFASAEF ILENNTYVCG SEVEKMSKSK
710 720 730 740 750
FNVVNPDDIV NKYGADTLRM YEMFLGPLEQ SKPWNTNGIE GVYKFLNRFW
760 770 780 790 800
RLFHDTAGNF AVSDAQPTAE ELKVLHKTLK RVEEDIERFS FNTPVSTFMI
810 820 830 840 850
CVNELGSLKC NKRTILEPLT IALSPLAPHI AEELWSLLGH TTSVSTATYP
860 870 880 890 900
AWDEKFLVES NHEYPISING KMRAKLNLPV DMPAAEVEQQ VLANEVVQKW
910 920
LEGKAPKKII VIPNKIVNVV M
Length:921
Mass (Da):104,655
Last modified:August 22, 2006 - v1
Checksum:iFEE623E5B6E57BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG58559.1.
RefSeqiWP_011584674.1. NC_008255.1.

Genome annotation databases

EnsemblBacteriaiABG58559; ABG58559; CHU_1287.
KEGGichu:CHU_1287.
PATRICi21593423. VBICytHut34013_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG58559.1.
RefSeqiWP_011584674.1. NC_008255.1.

3D structure databases

ProteinModelPortaliQ11VK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269798.CHU_1287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG58559; ABG58559; CHU_1287.
KEGGichu:CHU_1287.
PATRICi21593423. VBICytHut34013_1285.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-1285-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33406 / NCIMB 9469.

Entry informationi

Entry nameiSYL_CYTH3
AccessioniPrimary (citable) accession number: Q11VK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.