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Q11VK7

- SYL_CYTH3

UniProt

Q11VK7 - SYL_CYTH3

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Protein

Leucine--tRNA ligase

Gene
leuS, CHU_1287
Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei698 – 6981ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-1285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CHU_1287
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
ProteomesiUP000001822: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 921921Leucine--tRNA ligaseUniRule annotationPRO_1000074831Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_1287.

Structurei

3D structure databases

ProteinModelPortaliQ11VK7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotationAdd
BLAST
Motifi695 – 6995"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11VK7-1 [UniParc]FASTAAdd to Basket

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MADYHFGEVE NKWQSKWNAE KTFKALENSS KPKYFVLDMF PYPSGSGLHV    50
GHPLGYIASD IMARYKRIKG YNVLHPMGFD SFGLPAEQYA VQTGQHPAIT 100
TEQNIARYIE QLNKIGFSFD WDREIRTSDP AYYKWTQWIF IQLFNHWYNK 150
ASDKAEPITN LVKQFETAGN AGINAACDED AVTFTAADWK SYSEKQQSDT 200
LLKYRLTYLS ETMVNWCPGL GTVLANEEVK DGLSERGGFP VERKKMKQWS 250
MRITAYADRL LKGLDTIDWP EAMKEMQRYW IGKSLGAMLT FKVVDKDMEL 300
TVFTTRIDTT FGVTYVSIAP EHEWIGALTS PEQKAAVEEY VTKAKNRSER 350
DRMSDVKTVS GCFTGSYVTN PFNNEKIPVW IADYVLAGYG TGVVMAVPSS 400
DERDYKFASF YKLPIISVQE GAHTDITKED FDPKAGTMIN SGFLNGLTVK 450
QAIPEAIKFI EEKKIGFAKI NFKMRDSIFG RQRYWGEPIP VSYKNDIPYV 500
LNESELPLAL PAIDEYKPTE TGEPPLARNK AFADKGYELS TMPGWAGSSW 550
YFMRYMDPQN KTAVAAADKI NYWGQVDLYM GGAEHATGHL LYSRFWNKFL 600
FDMGITPNDE PFAKLINQGM IQGVSKFAYR INGTNKFVSA GLKKEYDTTP 650
IHVDVSIVHN DVLDTEAFKK WRPDFASAEF ILENNTYVCG SEVEKMSKSK 700
FNVVNPDDIV NKYGADTLRM YEMFLGPLEQ SKPWNTNGIE GVYKFLNRFW 750
RLFHDTAGNF AVSDAQPTAE ELKVLHKTLK RVEEDIERFS FNTPVSTFMI 800
CVNELGSLKC NKRTILEPLT IALSPLAPHI AEELWSLLGH TTSVSTATYP 850
AWDEKFLVES NHEYPISING KMRAKLNLPV DMPAAEVEQQ VLANEVVQKW 900
LEGKAPKKII VIPNKIVNVV M 921
Length:921
Mass (Da):104,655
Last modified:August 22, 2006 - v1
Checksum:iFEE623E5B6E57BFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000383 Genomic DNA. Translation: ABG58559.1.
RefSeqiWP_011584674.1. NC_008255.1.
YP_677899.1. NC_008255.1.

Genome annotation databases

EnsemblBacteriaiABG58559; ABG58559; CHU_1287.
GeneIDi4185986.
KEGGichu:CHU_1287.
PATRICi21593423. VBICytHut34013_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000383 Genomic DNA. Translation: ABG58559.1 .
RefSeqi WP_011584674.1. NC_008255.1.
YP_677899.1. NC_008255.1.

3D structure databases

ProteinModelPortali Q11VK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269798.CHU_1287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG58559 ; ABG58559 ; CHU_1287 .
GeneIDi 4185986.
KEGGi chu:CHU_1287.
PATRICi 21593423. VBICytHut34013_1285.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CHUT269798:GJ83-1285-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33406 / NCIMB 9469.

Entry informationi

Entry nameiSYL_CYTH3
AccessioniPrimary (citable) accession number: Q11VK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi