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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46S-adenosyl-L-methionineUniRule annotation1
Binding sitei71S-adenosyl-L-methionineUniRule annotation1
Active sitei120By similarity1
Binding sitei120S-adenosyl-L-methionineUniRule annotation1
Binding sitei156SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCHUT269798:G1G6N-1514-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CHU_1543
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
Proteomesi
  • UP000001822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881431 – 221tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST221

Proteomic databases

PRIDEiQ11UV2

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_1543

Structurei

3D structure databases

ProteinModelPortaliQ11UV2
SMRiQ11UV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UGT Bacteria
COG0220 LUCA
HOGENOMiHOG000251689
KOiK03439
OMAiWITFPDP
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q11UV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKLMRFK WNEEVHNLFQ PEKENYKAYK GKWHEYFKND NPVILEVGCG
60 70 80 90 100
RAEYTTGLAA LFPENNYIGL DIKGARLWKG SSLSIETGLT NTAFIRTKLQ
110 120 130 140 150
NLEEFFEPGE VKGIWITFPD PKPRESEAKL RLSGLRFMNI YRRLMPAGGK
160 170 180 190 200
VFFKTDNRVL FDHTLEVLTD QTLKIKDLVF THDLYQSPLL AEHYGIQTTY
210 220
EKTYLNQGVQ INYLKFEFLP L
Length:221
Mass (Da):25,884
Last modified:August 22, 2006 - v1
Checksum:i89915B9EC2C3BA26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA Translation: ABG58814.1
RefSeqiWP_011584929.1, NZ_FPJX01000010.1

Genome annotation databases

EnsemblBacteriaiABG58814; ABG58814; CHU_1543
KEGGichu:CHU_1543

Entry informationi

Entry nameiTRMB_CYTH3
AccessioniPrimary (citable) accession number: Q11UV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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