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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi495MagnesiumUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCHUT269798:G1G6N-1758-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CHU_1786
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
Proteomesi
  • UP000001822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296151 – 717Polyribonucleotide nucleotidyltransferaseAdd BLAST717

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_1786

Structurei

3D structure databases

ProteinModelPortaliQ11U61
SMRiQ11U61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 624KHUniRule annotationAdd BLAST63
Domaini634 – 703S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.101 hit
3.30.230.702 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q11U61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGLTIIN KTITLPDGRE IQIETGKLAK QADGSAVVKL GNAMILATVV
60 70 80 90 100
SAKEAKPGVD FMPLSVDYQE KFASNGKIPG GFLKRESRLS DYEILISRLV
110 120 130 140 150
DRAMRPLFPE DFHADTQVAI TLISADADVL PDALACLAAQ AAMSVSDIPF
160 170 180 190 200
NGPVSEVRVI SLNGEFIINP KPAQIEKAEL ELIVAASYDN VIMVEGEMSE
210 220 230 240 250
VSEELMLNAI KVAHDAIRTQ CIVLKELESA AGKTEKRTYS HEVNDWDLKK
260 270 280 290 300
KINDAVYQQV YEVAKLGNAN KNTRAEGFKA VKKAYIESLP ADHTEDLTLI
310 320 330 340 350
GKYYHDVEKD AVRNLILDER KRLDGRSLEQ IRPIWSEVGY LPSAHGSAIF
360 370 380 390 400
TRGETQSLTT VTFGTRLDEQ MIDSAMFSGN NKLMLHYNFP GFSTGEVKPN
410 420 430 440 450
RGPGRREVGH GNLAYRAIKK VMPPEIENPY TIRIVSDILE SNGSSSMATV
460 470 480 490 500
CAGTLALMDA GIKIKAPVSG IAMGLITDTK TGRWAVLSDI LGDEDHLGDM
510 520 530 540 550
DFKVTGTEKG ITACQMDIKV DGLSYDILSQ ALQQANRGRL HILSEMKKTL
560 570 580 590 600
ATPREDLKPH APRMIMIQIP KELIGAVIGP GGKIIQEIQK TSGATVNIEE
610 620 630 640 650
KDNAGWVSIF SKDKTALDSA LSQIKGIVTL PEVGEVYEGK VKSITAFGAF
660 670 680 690 700
VEFLPGKDGL LHISEIKWER LDTMEGVLEV GETVKVKLVE VDKKTGKYRL
710
SRKVLIPKPE QQATSNS
Length:717
Mass (Da):78,480
Last modified:August 22, 2006 - v1
Checksum:i696766F9F37EAAFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA Translation: ABG59053.1
RefSeqiWP_011585170.1, NZ_FPJX01000003.1

Genome annotation databases

EnsemblBacteriaiABG59053; ABG59053; CHU_1786
KEGGichu:CHU_1786

Similar proteinsi

Entry informationi

Entry nameiPNP_CYTH3
AccessioniPrimary (citable) accession number: Q11U61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 22, 2006
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome