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Q11U61

- PNP_CYTH3

UniProt

Q11U61 - PNP_CYTH3

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi495 – 4951MagnesiumUniRule annotation
Metal bindingi501 – 5011MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-1789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CHU_1786
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
ProteomesiUP000001822: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Polyribonucleotide nucleotidyltransferasePRO_0000329615Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_1786.

Structurei

3D structure databases

ProteinModelPortaliQ11U61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 62463KHUniRule annotationAdd
BLAST
Domaini634 – 70370S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiQAKEGRQ.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11U61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYPGLTIIN KTITLPDGRE IQIETGKLAK QADGSAVVKL GNAMILATVV
60 70 80 90 100
SAKEAKPGVD FMPLSVDYQE KFASNGKIPG GFLKRESRLS DYEILISRLV
110 120 130 140 150
DRAMRPLFPE DFHADTQVAI TLISADADVL PDALACLAAQ AAMSVSDIPF
160 170 180 190 200
NGPVSEVRVI SLNGEFIINP KPAQIEKAEL ELIVAASYDN VIMVEGEMSE
210 220 230 240 250
VSEELMLNAI KVAHDAIRTQ CIVLKELESA AGKTEKRTYS HEVNDWDLKK
260 270 280 290 300
KINDAVYQQV YEVAKLGNAN KNTRAEGFKA VKKAYIESLP ADHTEDLTLI
310 320 330 340 350
GKYYHDVEKD AVRNLILDER KRLDGRSLEQ IRPIWSEVGY LPSAHGSAIF
360 370 380 390 400
TRGETQSLTT VTFGTRLDEQ MIDSAMFSGN NKLMLHYNFP GFSTGEVKPN
410 420 430 440 450
RGPGRREVGH GNLAYRAIKK VMPPEIENPY TIRIVSDILE SNGSSSMATV
460 470 480 490 500
CAGTLALMDA GIKIKAPVSG IAMGLITDTK TGRWAVLSDI LGDEDHLGDM
510 520 530 540 550
DFKVTGTEKG ITACQMDIKV DGLSYDILSQ ALQQANRGRL HILSEMKKTL
560 570 580 590 600
ATPREDLKPH APRMIMIQIP KELIGAVIGP GGKIIQEIQK TSGATVNIEE
610 620 630 640 650
KDNAGWVSIF SKDKTALDSA LSQIKGIVTL PEVGEVYEGK VKSITAFGAF
660 670 680 690 700
VEFLPGKDGL LHISEIKWER LDTMEGVLEV GETVKVKLVE VDKKTGKYRL
710
SRKVLIPKPE QQATSNS
Length:717
Mass (Da):78,480
Last modified:August 22, 2006 - v1
Checksum:i696766F9F37EAAFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG59053.1.
RefSeqiWP_011585170.1. NC_008255.1.
YP_678395.1. NC_008255.1.

Genome annotation databases

EnsemblBacteriaiABG59053; ABG59053; CHU_1786.
GeneIDi4184682.
KEGGichu:CHU_1786.
PATRICi21594419. VBICytHut34013_1775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG59053.1 .
RefSeqi WP_011585170.1. NC_008255.1.
YP_678395.1. NC_008255.1.

3D structure databases

ProteinModelPortali Q11U61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269798.CHU_1786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG59053 ; ABG59053 ; CHU_1786 .
GeneIDi 4184682.
KEGGi chu:CHU_1786.
PATRICi 21594419. VBICytHut34013_1775.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi QAKEGRQ.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CHUT269798:GJ83-1789-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33406 / NCIMB 9469.

Entry informationi

Entry nameiPNP_CYTH3
AccessioniPrimary (citable) accession number: Q11U61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3