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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
Binding sitei88 – 881S-adenosyl-L-methionineUniRule annotation
Binding sitei133 – 1331S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCHUT269798:GJ83-2706-MONOMER.
UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:CHU_2710Imported
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)Imported
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
ProteomesiUP000001822 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_2710.

Structurei

3D structure databases

ProteinModelPortaliQ11RK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1172S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249464.
KOiK03183.
OMAiCLEFSHV.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11RK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATVKPYQE MESGKREQVE LMFNNISPKY DLLNRVLSLG IDKIWRKQAL
60 70 80 90 100
NLLKQDKPAH ILDVATGTAD LAIEAATRLK PTSVVGIDIA EDMLQIGRGK
110 120 130 140 150
IAKKNLDKII RLEKGDSEKI NFPDNTFDAV IVSFGVRNFE HLEIGLAEIH
160 170 180 190 200
RVLKPAGSIM VLEFSKPQNA PFKQVYQFYF KNILPTVGKL ISKDSAAYTY
210 220 230 240
LPDSVNAFPD GKAFCSILEK TGFTIKHYKP YTFGVCTAYV GKK
Length:243
Mass (Da):27,205
Last modified:August 22, 2006 - v1
Checksum:i50BF980D42D47E7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG59961.1.
RefSeqiWP_011586071.1. NC_008255.1.
YP_679303.1. NC_008255.1.

Genome annotation databases

EnsemblBacteriaiABG59961; ABG59961; CHU_2710.
KEGGichu:CHU_2710.
PATRICi21596303. VBICytHut34013_2709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG59961.1.
RefSeqiWP_011586071.1. NC_008255.1.
YP_679303.1. NC_008255.1.

3D structure databases

ProteinModelPortaliQ11RK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269798.CHU_2710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG59961; ABG59961; CHU_2710.
KEGGichu:CHU_2710.
PATRICi21596303. VBICytHut34013_2709.

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249464.
KOiK03183.
OMAiCLEFSHV.
OrthoDBiEOG6M6JSB.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
BioCyciCHUT269798:GJ83-2706-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33406 / NCIMB 9469Imported.

Entry informationi

Entry nameiQ11RK3_CYTH3
AccessioniPrimary (citable) accession number: Q11RK3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: May 27, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.