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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68S-adenosyl-L-methionineUniRule annotation1
Binding sitei88S-adenosyl-L-methionineUniRule annotation1
Binding sitei133S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processMenaquinone biosynthesisUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCHUT269798:G1G6N-2667-MONOMER
UniPathwayiUPA00079; UER00169

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:CHU_2710Imported
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)Imported
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
Proteomesi
  • UP000001822 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_2710

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 117S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DDZ Bacteria
COG2226 LUCA
HOGENOMiHOG000249464
KOiK03183
OMAiVRNFENL
OrthoDBiPOG091H01LK

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q11RK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATVKPYQE MESGKREQVE LMFNNISPKY DLLNRVLSLG IDKIWRKQAL
60 70 80 90 100
NLLKQDKPAH ILDVATGTAD LAIEAATRLK PTSVVGIDIA EDMLQIGRGK
110 120 130 140 150
IAKKNLDKII RLEKGDSEKI NFPDNTFDAV IVSFGVRNFE HLEIGLAEIH
160 170 180 190 200
RVLKPAGSIM VLEFSKPQNA PFKQVYQFYF KNILPTVGKL ISKDSAAYTY
210 220 230 240
LPDSVNAFPD GKAFCSILEK TGFTIKHYKP YTFGVCTAYV GKK
Length:243
Mass (Da):27,205
Last modified:August 22, 2006 - v1
Checksum:i50BF980D42D47E7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA Translation: ABG59961.1
RefSeqiWP_011586071.1, NZ_FPJX01000002.1

Genome annotation databases

EnsemblBacteriaiABG59961; ABG59961; CHU_2710
KEGGichu:CHU_2710

Similar proteinsi

Entry informationi

Entry nameiQ11RK3_CYTH3
AccessioniPrimary (citable) accession number: Q11RK3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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