ID   K6PF_CYTH3              Reviewed;         328 AA.
AC   Q11RE2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=6-phosphofructokinase;
DE            Short=Phosphofructokinase;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphohexokinase;
GN   Name=pfkA; OrderedLocusNames=CHU_2773;
OS   Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469).
OC   Bacteria; Bacteroidetes; Sphingobacteria; Sphingobacteriales;
OC   Flexibacteraceae; Cytophaga.
OX   NCBI_TaxID=269798;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17400776; DOI=10.1128/AEM.00225-07;
RA   Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C.,
RA   Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P.,
RA   Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B.,
RA   Wilson D.B., McBride M.J.;
RT   "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT   hutchinsonii.";
RL   Appl. Environ. Microbiol. 73:3536-3546(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000383; ABG60022.1; -; Genomic_DNA.
DR   RefSeq; YP_679364.1; -.
DR   GeneID; 4186262; -.
DR   GenomeReviews; CP000383_GR; CHU_2773.
DR   KEGG; chu:CHU_2773; -.
DR   NMPDR; fig|269798.12.peg.2660; -.
DR   HOGENOM; Q11RE2; -.
DR   OMA; Q11RE2; CLGVDTA.
DR   BioCyc; CHUT269798:CHU_2773-MON; -.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00339; -; 1.
DR   InterPro; IPR012003; ATP_PFK_prok.
DR   InterPro; IPR012828; PFKA_ATP.
DR   InterPro; IPR000023; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   Pfam; PF00365; PFK; 1.
DR   PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   ProDom; PD000707; Ppfruckinase; 1.
DR   TIGRFAMs; TIGR02482; PFKA_ATP; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
KW   Magnesium; Metal-binding; Nucleotide-binding; Transferase.
FT   CHAIN         1    328       6-phosphofructokinase.
FT                                /FTId=PRO_1000059756.
FT   NP_BIND      21     25       ATP (By similarity).
FT   NP_BIND     155    159       ATP (By similarity).
FT   NP_BIND     172    188       ATP (By similarity).
FT   ACT_SITE    128    128       Proton acceptor (By similarity).
FT   METAL       186    186       Magnesium; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       188    188       Magnesium (By similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     247    247       Substrate (By similarity).
FT   BINDING     253    253       Substrate (By similarity).
FT   BINDING     256    256       Substrate (By similarity).
SQ   SEQUENCE   328 AA;  35478 MW;  A3897A05791AB459 CRC64;
     MKKIAVYTSG GDAPGMNACI RAAVRAGHYH NLEVYGIVRG YDGMINGNFI ELDNRAVSNI
     IQKGGTILKS ARSEEFRSPE GRRKAFDQIQ KFGIDGLVAI GGNGTFTGAE LFYNEYQIPC
     VGAPGTIDND LYGSDFTIGY DTAVNTCLAA IDKIRDTADA HERVFFIEVM GRDTGYIAVR
     SAISGGAEMA IIPEFPYDKN VVINRLKHGT SDTKASHIII VAEGHQEGRA SMIARDIKEA
     LPQLDCRVTT LGHVQRGGGP SAADRVLASR LGLATVEGLL EGRANVMAGI IDHKVVYTPF
     IDTITKRKPI NEDLLSLAEK LNGRSYKV
//