ID   BIOD_CYTH3              Reviewed;         206 AA.
AC   Q11QU6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   05-MAY-2009, entry version 20.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=CHU_2977;
OS   Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469).
OC   Bacteria; Bacteroidetes; Sphingobacteria; Sphingobacteriales;
OC   Flexibacteraceae; Cytophaga.
OX   NCBI_TaxID=269798;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17400776; DOI=10.1128/AEM.00225-07;
RA   Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C.,
RA   Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P.,
RA   Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B.,
RA   Wilson D.B., McBride M.J.;
RT   "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT   hutchinsonii.";
RL   Appl. Environ. Microbiol. 73:3536-3546(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000383; ABG60218.1; -; Genomic_DNA.
DR   RefSeq; YP_679560.1; -.
DR   GeneID; 4185086; -.
DR   GenomeReviews; CP000383_GR; CHU_2977.
DR   KEGG; chu:CHU_2977; -.
DR   NMPDR; fig|269798.12.peg.2842; -.
DR   HOGENOM; Q11QU6; -.
DR   OMA; Q11QU6; SPHWAAE.
DR   BioCyc; CHUT269798:CHU_2977-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    206       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302504.
FT   NP_BIND       8     16       ATP (By similarity).
SQ   SEQUENCE   206 AA;  22683 MW;  5C2D2F081B2D480C CRC64;
     MKKYFITAIS TDSGKTLVSA ILTNALQADY WKPVQAGLEE TDSNTIRTLL HSGHSIIHPE
     AYALKQAVSP HAAARNEGVE IVLAAIQLPD TNGNDLIIEG AGGVLVPLND TDVVADLITQ
     FDAEVILVSN LYLGSINHTL LTAQELKRRN IRVKGIVFNG PRNEESERII LKHTGYKVLL
     HVSPEEKITK EVVTAYAVKL FDNWYE
//