Reviewed, UniProtKB/Swiss-Prot Q11QU6 (BIOD_CYTH3)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase
    DTB synthetase
      Short name=DTBS

Gene names

Name:	bioD
Ordered Locus Names:	CHU_2977

Organism

Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP]

Taxonomic identifier

269798 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Sphingobacteria › Sphingobacteriales › Flexibacteraceae › Cytophaga

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 6-carboxyhexanoyl-CoA: step 3/4. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Dethiobiotin synthetase HAMAP MF_00336		PRO_0000302504
Regions
	Nucleotide binding	8 – 16	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11QU6-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 5C2D2F081B2D480C	FASTA	206	22,683
	10 20 30 40 50 60 MKKYFITAIS TDSGKTLVSA ILTNALQADY WKPVQAGLEE TDSNTIRTLL HSGHSIIHPE 70 80 90 100 110 120 AYALKQAVSP HAAARNEGVE IVLAAIQLPD TNGNDLIIEG AGGVLVPLND TDVVADLITQ 130 140 150 160 170 180 FDAEVILVSN LYLGSINHTL LTAQELKRRN IRVKGIVFNG PRNEESERII LKHTGYKVLL 190 200 HVSPEEKITK EVVTAYAVKL FDNWYE

References

[1]

"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii." Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J. Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000383 Genomic DNA. Translation: ABG60218.1.
RefSeq	YP_679560.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4185086.
GenomeReviews	Gene locus CHU_2977 in contig CP000383_GR.
KEGG	chu:CHU_2977.
NMPDR	fig|269798.12.peg.2842.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q11QU6.
OMA	Q11QU6. SPHWAAE.
Enzyme and pathway databases
BioCyc	CHUT269798:CHU_2977-MON.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD_CYTH3

Accession

Primary (citable) accession number: Q11QU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 22, 2006
Last modified:	May 5, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)