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Protein

Malate dehydrogenase

Gene

mdh

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADUniRule annotation1
Binding sitei82SubstrateUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei95NADUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADUniRule annotation6
Nucleotide bindingi118 – 120NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:CHU_3020
OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Taxonomic identifieri269798 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
Proteomesi
  • UP000001822 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264701 – 312Malate dehydrogenaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi269798.CHU_3020.

Structurei

3D structure databases

ProteinModelPortaliQ11QQ3.
SMRiQ11QQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11QQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVVGAGN VGATCADVLA YREIVNEVIL LDIKEGVAEG KALDIWQKAP
60 70 80 90 100
ITQYDTKTTG VTNDYSKTAN SDVVVITSGL PRKPGMTRDD LISTNAGIVR
110 120 130 140 150
AVTESVVKYS PNAIIIVVSN PLDVMTYCAH ITSKLPRNKV IGMAGVLDTA
160 170 180 190 200
RYRAFLADEI GCSPKEIQGM LLGGHGDTMV PLPRYTTVGG IPVTELVEAD
210 220 230 240 250
KLNAIIERTK NGGGELVKLM GTSAWYAPGA AAAQMVEAIV KDQKKIIPVC
260 270 280 290 300
IKLEGEYGID DCYLGVPAVI GKNGIEKVIE LKLNAEEKAL METSRKHVKE
310
VMNVLDGLPQ QA
Length:312
Mass (Da):33,351
Last modified:August 22, 2006 - v1
Checksum:iB0C3C5CA64561F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000383 Genomic DNA. Translation: ABG60261.1.
RefSeqiWP_011586371.1. NZ_FPJX01000002.1.

Genome annotation databases

EnsemblBacteriaiABG60261; ABG60261; CHU_3020.
KEGGichu:CHU_3020.

Similar proteinsi

Entry informationi

Entry nameiMDH_CYTH3
AccessioniPrimary (citable) accession number: Q11QQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families