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Q11PQ4

- SYE_CYTH3

UniProt

Q11PQ4 - SYE_CYTH3

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei269 – 2691ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHUT269798:GJ83-3369-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:CHU_3373
    OrganismiCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
    Taxonomic identifieri269798 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeCytophaga
    ProteomesiUP000001822: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Glutamate--tRNA ligasePRO_0000330966Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269798.CHU_3373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11PQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi14 – 2411"HIGH" regionAdd
    BLAST
    Motifi266 – 2705"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiKKLWFFN.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11PQ4-1 [UniParc]FASTAAdd to Basket

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    MSDTNKQVRV RFAPSPTGPL HIGGVRTALY NYLFARKMGG KMLLRIEDTD    50
    QNRFVPGAEA YIQEALAWVG IVIDEGAGVG GPHAPYKQSE RKPMYREYAE 100
    KLIAEGNAYY AFDTSEELEA MKERLKAAKV ASPSYNMVTR MQMNNSLTLP 150
    EDEVKRRLDA GDEYVIRLKV PRKEEIRLND MIRGWVVVHS STIDDKVLLK 200
    SDGMPTYHLA NIVDDHLMEI THVIRGEEWL PSAPLHVLLY RFLGWEDTMP 250
    QFAHLPLLLK PDGNGKLSKR DADAGGFPIF PLDWKDPASG DTWIGFKQQG 300
    YLQEATTNFL AFLGWNPGTQ QELFTMDELI EAFTVERIGK SGTKFDINKA 350
    KWYNQQYMRQ LPDETLTRLL KEEADKHQAK YDAAKLPLIA QMLKERLTFA 400
    KDYWIEGQFF FEAPETFDEK VASTKWNAEA VTVISAYKEA LAAYTGEFNA 450
    ENVKHVLHEV LEKADVKIGK IMQALRLALT GAGAGPDLMQ FIEIVGKEEA 500
    IKRMQFALIT LSEKVNS 517
    Length:517
    Mass (Da):58,622
    Last modified:August 22, 2006 - v1
    Checksum:iDC98D665678A2C4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG60609.1.
    RefSeqiYP_679952.1. NC_008255.1.

    Genome annotation databases

    EnsemblBacteriaiABG60609; ABG60609; CHU_3373.
    GeneIDi4187162.
    KEGGichu:CHU_3373.
    PATRICi21597625. VBICytHut34013_3357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000383 Genomic DNA. Translation: ABG60609.1 .
    RefSeqi YP_679952.1. NC_008255.1.

    3D structure databases

    ProteinModelPortali Q11PQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269798.CHU_3373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG60609 ; ABG60609 ; CHU_3373 .
    GeneIDi 4187162.
    KEGGi chu:CHU_3373.
    PATRICi 21597625. VBICytHut34013_3357.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi KKLWFFN.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci CHUT269798:GJ83-3369-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33406 / NCIMB 9469.

    Entry informationi

    Entry nameiSYE_CYTH3
    AccessioniPrimary (citable) accession number: Q11PQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3