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Q11PP6 (Q11PP6_CYTH3) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
Name:iscS EMBL ABG60617.1
Ordered Locus Names:CHU_3381
OrganismCytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP] EMBL ABG60617.1
Taxonomic identifier269798 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga ›

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
Q11PP6 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 540337C0D6770312

FASTA43248,766
        10         20         30         40         50         60 
MPTKFLITRA YSVQLDKEDP LAEFRKEFLF PGPPAAKAYF CGHSLGLQPK RTKELMLHEL 

        70         80         90        100        110        120 
ADWEKWGVEG HWKAANPWLH YHQSFAKPLS VLAGAYPDEV VAMNSLTTNL HFMLASFYRP 

       130        140        150        160        170        180 
AGKKIKIITE AWNFPSDRFA LESLVKLYGY DPKKVIIELK PGKKNTALTT EEICASIQKN 

       190        200        210        220        230        240 
KDSLALVVLS GVNYYSGQAF DMERISQATH LAGAFVGFDL AHAIGNIPLH LHDWKVDFAV 

       250        260        270        280        290        300 
WCSYKYLNGG PGAVGGAFVH QKHGHDKTTP RMAGWWGHDH NTRFNLEGTY KPLSGAAGFQ 

       310        320        330        340        350        360 
VSNAPVFNMI GLKASLDIFM QAGLTAINKK RTTMFNYMVF LIHALCTEDQ KKAFSIQMIT 

       370        380        390        400        410        420 
PVTQQQHGSM LSIRVEKNKG KQLFDLLSKQ GFMLDWREPD VIRIAPVPLY NKYQEIYSFV 

       430 
LELSKHAVLV RL

« Hide

References

[1]"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii."
Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J.
Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33406 / NCIMB 9469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000383 Genomic DNA. Translation: ABG60617.1.
RefSeqYP_679960.1. NC_008255.1.

3D structure databases

ProteinModelPortalQ11PP6.
ModBaseSearch...

Protein-protein interaction databases

STRING269798.CHU_3381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG60617; ABG60617; CHU_3381.
GeneID4187170.
KEGGchu:CHU_3381.
PATRIC21597641. VBICytHut34013_3365.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242438.
KOK01556.
OMAMVSFYRP.

Enzyme and pathway databases

BioCycCHUT269798:GJ83-3377-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ11PP6_CYTH3
AccessionPrimary (citable) accession number: Q11PP6
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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