Q11NV3 (Q11NV3_CYTH3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipoprotein signal peptidase HAMAP MF_00161
EC=3.4.23.36 HAMAP MF_00161

Alternative name(s):
Prolipoprotein signal peptidase HAMAP MF_00161
Signal peptidase II HAMAP MF_00161

Gene names

Name:	lspA HAMAP MF_00161
Ordered Locus Names:	CHU_3677

Organism

Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) [Complete proteome] [HAMAP] EMBL ABG60910.1

Taxonomic identifier

269798 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Cytophaga

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161
Catalytic activity	Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161
Pathway	Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.
Sequence similarities	Belongs to the peptidase A8 family. HAMAP MF_00161

Ontologies

Keywords
Cellular component	Cell inner membrane HAMAP MF_00161 Cell membrane Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00161
Molecular function	Aspartyl protease HAMAP MF_00161 Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	6 – 26	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	67 – 87	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	96 – 116	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	164 – 184	21	Helical; By similarity HAMAP MF_00161
Sites
	Active site	113	1	By similarity HAMAP MF_00161
	Active site	172	1	By similarity HAMAP MF_00161

Sequences

	Sequence		Length	Mass (Da)
	Q11NV3 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 04B91E59D992C42F	FASTA	205	23,569
	10 20 30 40 50 60 MRYTKYFLLT IGIILIDQVI KLWVFETFPF EGYEHPSLRL GDWFKLHYIT NEGMAFGIKL 70 80 90 100 110 120 AGVYGKLILS LFRLVAMVGI SYYLYLMAKK GMHEGFLWCI ALILGGAMGN VVDSTFYGVF 130 140 150 160 170 180 LDLPTSDAPM LWFHGRVIDM FYVDICNCLI PEWVPVLGGS YYPLWPIFNF ADASIFVGVA 190 200 LILIYQKKFF PEKDGVKEKE QHVQV

References

[1]

"Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii." Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B., McBride M.J. Appl. Environ. Microbiol. 73:3536-3546(2007) [PubMed: 17400776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000383 Genomic DNA. Translation: ABG60910.1.
RefSeq	YP_680253.1. NC_008255.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q11NV3.
Protein family/group databases
MEROPS	A08.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4184650.
GenomeReviews	Gene locus CHU_3677 in contig CP000383_GR.
KEGG	chu:CHU_3677.
NMPDR	fig|269798.12.peg.3503.
PATRIC	21598235. VBICytHut34013_3662.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG78647.
HOGENOM	HBG724422.
OMA	HGKVVDM.
Family and domain databases
HAMAP	MF_00161. LspA. [Tree]
InterPro	IPR001872. Peptidase_A8. [Graphical view]
KO	K03101.
Pfam	PF01252. Peptidase_A8. 1 hit. [Graphical view]
PRINTS	PR00781. LIPOSIGPTASE.
ProtoNet	Search...

Entry information

Entry name

Q11NV3_CYTH3

Accession

Primary (citable) accession number: Q11NV3

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)