Q11L82 (LPXK_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraacyldisaccharide 4'-kinase
EC=2.7.1.130

Alternative name(s):
Lipid A 4'-kinase

Gene names

Name:	lpxK
Ordered Locus Names:	Meso_0439

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity. HAMAP MF_00409
Catalytic activity	ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409
Sequence similarities	Belongs to the LpxK family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetraacyldisaccharide 4'-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Tetraacyldisaccharide 4'-kinase HAMAP MF_00409		PRO_0000291214
Regions
	Nucleotide binding	55 – 62	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q11L82 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 730FBD7B7555BD05	FASTA	343	37,399
	10 20 30 40 50 60 MAASEAPPFW WEKPDWRAWA LWPLSSAYGF AASARLRAAK REKIPAAVLC IGNLTVGGEG 70 80 90 100 110 120 KTPIAIALAR HAMRKGLTVG FLSRGYGGSH FKPHIVSPED DSARAVGDEP LLLARQALTV 130 140 150 160 170 180 ISRDRAAGAR RLVQAGCNLI IMDDGFQSAR LHMDYALIVV DAMRGLGNGH VFPAGPMRAP 190 200 210 220 230 240 LTEQMRFADG VVTMGEGDAA DIVVRSASRA GRPVYSARIR PRSRNGLKGK RVLAFAGIGN 250 260 270 280 290 300 PRKFYATLKA CGADIVLERS FPDHHLFTEE DVSELSREAA KESLLLVTTE KDFVRLQNSM 310 320 330 340 QPMRDFAASV QALKVEAVFD EPGAPDAIIN AAQQAWRERM LKR

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG61843.1.
RefSeq	YP_673008.1. NC_008254.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q11L82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4179980.
GenomeReviews	Gene locus Meso_0439 in contig CP000390_GR.
KEGG	mes:Meso_0439.
NMPDR	fig|266779.1.peg.2586.
PATRIC	21340758. VBICheSp72577_1025.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1663.
HOGENOM	HBG663914.
OMA	VILMDDG.
PhylomeDB	Q11L82.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_0439-MONOMER.
Family and domain databases
HAMAP	MF_00409. LpxK. [Tree]
InterPro	IPR003758. Tetraacyldisaccharide_4-kinase. [Graphical view]
KO	K00912.
Pfam	PF02606. LpxK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00682. LpxK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXK_MESSB

Accession

Primary (citable) accession number: Q11L82

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program