Reviewed, UniProtKB/Swiss-Prot Q11L77 (TDH_MESSB)

Names and origin

Protein names

Recommended name:
    L-threonine 3-dehydrogenase
    EC=1.1.1.103

Gene names

Name:	tdh
Ordered Locus Names:	Meso_0444

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	L-threonine 3-dehydrogenase HAMAP MF_00627		PRO_1000051644
Sites
	Metal binding	42	1	Zinc 1; catalytic By similarity
	Metal binding	67	1	Zinc 1; catalytic By similarity
	Metal binding	97	1	Zinc 2 By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	103	1	Zinc 2 By similarity
	Metal binding	111	1	Zinc 2 By similarity
	Metal binding	152	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11L77-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 70877B78CDB76DAC	FASTA	344	37,428
	10 20 30 40 50 60 MTNMMKALVK AKPEEGLWME RVPLPEIGPN DVLIKVRKAA ICGTDVHIWN WDEWARKTVP 70 80 90 100 110 120 VPLVTGHEFV GEVVDVGSAV TEYRIGQRVS GEGHIVCGHC RNCRAGRGHL CRNTLGVGVH 130 140 150 160 170 180 RPGAFAEYIS LPQHNVVAIP DDVPDEIAAI FDPLGNAVHT ALSFDLVGED VLVTGAGPIG 190 200 210 220 230 240 IMGALVAQCV GARKVVITDI NPGRLALAKK LGVRHVVNAR EEKLTDVMRK LGMTEGFDVG 250 260 270 280 290 300 LEMSGSASAF RDMIDVMNNG GKIAILGIAP TGFEIDWNKV IFKMLHLKGI YGREMFETWY 310 320 330 340 KMIALVQGPL DISGLITHRI SADDYREGFA AMRSGEAGKV VMDW

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000390 Genomic DNA. Translation: ABG61848.1.
RefSeq	YP_673013.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q11L77.
Genome annotation databases
GeneID	4179985.
GenomeReviews	Gene locus Meso_0444 in contig CP000390_GR.
KEGG	mes:Meso_0444.
NMPDR	fig|266779.1.peg.2591.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q11L77.
OMA	IWMVDAP.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_0444-MON.
Family and domain databases
HAMAP	MF_00627. [Tree]
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR004627. L-Threonine_3-DHase. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProDom	PD040557. GroES_related. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00692. tdh. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_MESSB

Accession

Primary (citable) accession number: Q11L77

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)