Q11KC6 (KHSE_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Meso_0749

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Homoserine kinase HAMAP MF_00301		PRO_0000300794

Sequences

	Sequence		Length	Mass (Da)
	Q11KC6 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: BB2B9EE2742386BB	FASTA	322	36,289
	10 20 30 40 50 60 MAVYTDISEE ELTAFLRHYP VGKLLSYKGI AEGTENSNYL LHTTAGAYIL TLYERRVDRS 70 80 90 100 110 120 DLPFFLGLME HLARKGVSCP LPVKRLDDGL IGELAGRPAA LITFLEGMWM RRPTALHCGQ 130 140 150 160 170 180 VGKALADLHQ AAEDFPLKRP NALGPEGWRR LWEGAKARAD EVEPGLAREV DAEFALLERD 190 200 210 220 230 240 WPKDLPSGVI HADLFPDNVF FLGGELSGLI DFYFACNDLL AYDLATCLNA WCFEKDISYN 250 260 270 280 290 300 LTKGAALLAG YQAVRPLTRE EIEMLPLLAR GSALRFMLTR LYDWLTIPDG ALVKKRDPLE 310 320 YLRRLRFHRQ VRTASEYGIE LA

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG62149.1.
RefSeq	YP_673314.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11KC6.
SMR	Q11KC6. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11KC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4181127.
GenomeReviews	Gene locus Meso_0749 in contig CP000390_GR.
KEGG	mes:Meso_0749.
NMPDR	fig|266779.1.peg.2887.
PATRIC	21341412. VBICheSp72577_1351.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_0749-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_MESSB

Accession

Primary (citable) accession number: Q11KC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program