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Q11JT7 (DAPA_MESSB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:Meso_0941
OrganismMesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000340967

Regions

Region48 – 492Pyruvate binding By similarity

Sites

Active site1621Schiff-base intermediate with substrate By similarity
Binding site1061Pyruvate By similarity
Site1331Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11JT7 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: E5AD45E3A97240D8

FASTA29331,303
        10         20         30         40         50         60 
MFRGSITALV TPFRQDGSLD KKAFGALVEW QIAEGSSGLV PVGTTGESPT LTHDEHQEVI 

        70         80         90        100        110        120 
RLCVEAANKR VPVIAGAGSN STREAISFAE HAEKVGADAL LVVTPYYNKP NQRGLYEHFA 

       130        140        150        160        170        180 
AIARSTSLPI FIYNIPPRSV VDMLPETMAR LAADFKNIVG VKDATAKLDR VSEQREACGP 

       190        200        210        220        230        240 
DFIQLSGEDA TALGFNAHGG VGCISVTANV APRLCAEFQA ASLRGDGARA IELQDRLFPL 

       250        260        270        280        290 
HKALFLEPNP AGAKYALSRL GRLENVLRSP LVTVEASTAE KIDAAMKHAG LLN

« Hide

References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000390 Genomic DNA. Translation: ABG62338.1.
RefSeqYP_673503.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11JT7.
SMRQ11JT7. Positions 1-292.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11JT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4180318.
GenomeReviewsGene locus Meso_0941 in contig CP000390_GR.
KEGGmes:Meso_0941.
NMPDRfig|266779.1.peg.3911.
PATRIC21341828. VBICheSp72577_1555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMAHFKAVHD.
PhylomeDBQ11JT7.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycMSP266779:MESO_0941-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_MESSB
AccessionPrimary (citable) accession number: Q11JT7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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