Q11J68 (ARGC_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Meso_1161

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000065142
Sites
	Active site	116	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11J68 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 3DB0518A69AF63CE	FASTA	310	33,593
	10 20 30 40 50 60 MTAKIFIDGE HGTTGLQIRA RLGERRDIEL LSIPVERRKD PAARAEFLNA ADIAILCLPD 70 80 90 100 110 120 DAARESVSLI ANDTTRVIDA STAYRVSEGW AYGFPEMDKS QSKAIAQAKR VANPGCWPQG 130 140 150 160 170 180 PIALLRPLVS AGLLPADFPV TINGITGYSG GGRSMIEDYE GKGEDAPEFF PYGLTLSHKH 190 200 210 220 230 240 LPELRTYAKL ARDPLMQPVV GNFAQGMITM VPLQLGHLPR VPKGEELHAA IADHYAGIEG 250 260 270 280 290 300 SAVEVAPFQA IERSPEIEPE RYNDTNTMRL YVFANDARAQ ALLLAVYDNL GKGASGAAVQ 310 NLDLMLSGLR

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG62557.1.
RefSeq	YP_673722.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11J68.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11J68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4179620.
GenomeReviews	Gene locus Meso_1161 in contig CP000390_GR.
KEGG	mes:Meso_1161.
NMPDR	fig|266779.1.peg.2424.
PATRIC	21342296. VBICheSp72577_1784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	PIFVPSV.
ProtClustDB	PRK11863.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_1161-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MESSB

Accession

Primary (citable) accession number: Q11J68

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program