Q11IV0 (PURQ_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine synthase 1
EC=6.3.5.3

Alternative name(s):
Phosphoribosylformylglycinamidine synthase I
Short name=FGAM synthase I

Gene names

Name:	purQ
Ordered Locus Names:	Meso_1279

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00421
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00421
Subunit structure	Heterodimer of two subunits, PurQ and PurL By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Domain	Glutamine amidotransferase
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glutamine metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Phosphoribosylformylglycinamidine synthase 1 HAMAP-Rule MF_00421		PRO_0000252711
Regions
	Domain	3 – 222	220	Glutamine amidotransferase type-1
Sites
	Active site	86	1	Nucleophile By similarity
	Active site	196	1	By similarity
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11IV0 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 1F45EC7BDC6B12BC	FASTA	222	23,334
	10 20 30 40 50 60 MKSAVIQLPG LNRDRDMIAA LTKISGQAPV TVWQTETELP EVDLIVIPGG FSYGDYLRCG 70 80 90 100 110 120 AIAARMPVMK AVAEKAAKGV LVIGVCNGFQ ILLEAGLLPG ALMRNASLKF VCREVKLQVA 130 140 150 160 170 180 NANTAFTRAY APGQIIRCPV AHHDGNFFAA PETLARIEGE GQVAFRYAEG TNPNGSINDI 190 200 210 220 AGIVNGAGNV LGLMPHPENL VEAAHGGTDG RALFESVLGR AA

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG62675.1.
RefSeq	YP_673840.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11IV0.
ModBase	Search...
Protein-protein interaction databases
STRING	266779.Meso_1279.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG62675; ABG62675; Meso_1279.
GeneID	4180538.
KEGG	mes:Meso_1279.
PATRIC	21342554. VBICheSp72577_1910.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0047.
HOGENOM	HOG000238240.
KO	K01952.
OMA	VLYRYCS.
ProtClustDB	PRK03619.
Enzyme and pathway databases
BioCyc	CSP266779:GI09-1347-MONOMER.
UniPathway	UPA00074; UER00128.
Family and domain databases
HAMAP	MF_00421. PurQ.
InterPro	IPR017926. GATASE_1. IPR010075. PRibForGlyAmidine_synth_I. [Graphical view]
PIRSF	PIRSF001586. FGAM_synth_I. 1 hit.
TIGRFAMs	TIGR01737. FGAM_synth_I. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PURQ_MESSB

Accession

Primary (citable) accession number: Q11IV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program