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Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

Meso_1332

Organism
Chelativorans sp. (strain BNC1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

adenosylcob(III)alaminUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processDNA synthesisUniRule annotation
LigandCobalaminUniRule annotation, Cobalt, Nucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12-dependent ribonucleotide reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Ordered Locus Names:Meso_1332Imported
OrganismiChelativorans sp. (strain BNC1)Imported
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
Proteomesi
  • UP000001820 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_1332.

Structurei

3D structure databases

ProteinModelPortaliQ11IP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 147Ribonuc_red_2_NInterPro annotationAdd BLAST117
Domaini198 – 734RIBORED_LARGEInterPro annotationAdd BLAST537
Domaini816 – 912RIBORED_LARGEInterPro annotationAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1168 – 1195Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase class-2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4107RTZ. Bacteria.
COG0209. LUCA.
HOGENOMiHOG000021770.
KOiK00525.
OMAiPQQVSAC.
OrthoDBiPOG091H0FGZ.

Family and domain databases

CDDicd02888. RNR_II_dimer. 1 hit.
InterProiView protein in InterPro
IPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
IPR029072. YebC-like.
PfamiView protein in Pfam
PF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 2 hits.
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF75625. SSF75625. 1 hit.
TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11IP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIERRFTKE GQSPYSEIPF RKALSEIKNP DGSIVFRLDD IDVPAQFSQV
60 70 80 90 100
AADILAQKYF RKAGVPARLK KVEENDVPSF LWRSVADEAA LSELPEEQRY
110 120 130 140 150
GSETDARQVF TRLAGTWTYW GWKGGYFDSE ADARAFMDEL SYMLATQRVA
160 170 180 190 200
PNSPQWFNTG LHWAYGIDGP GQGHYYVDPF TGKLTKSKSA YEHPQPHACF
210 220 230 240 250
IQSVADDLVN EGGIMDLWVR EARLFKYGSG TGSNFSQLRG EGEKLSGGGK
260 270 280 290 300
SSGLMSFLKI GDRAAGAIKS GGTTRRAAKM VIVDADHPDI EAFIDWKVNE
310 320 330 340 350
EQKVAALVTG SKIVRKHLDA IMKACINCEG ANDDCFDPAK NPALKREIKA
360 370 380 390 400
AKKNAVPENY VKRVIQFAKQ GYTSIEFKTY DTDWDSEAYL TVSGQNSNNS
410 420 430 440 450
VSIKDDFLRA VENDGDWTLI RRIDGKPGKT IKARDLWEKI GYAAWASADP
460 470 480 490 500
GLHFNTTMND WHTSPAAGPI RASNPCSEYM FLDDTACNLA SINLLAYRGK
510 520 530 540 550
DGRIDIEGYE HSVRLWTIVL EISVMMAQFP SKEIAKLSYE YRTLGLGYAN
560 570 580 590 600
IGGLLMTSGI PYDSDEGRAI CGALTAIMTG VAYATSAEMA AELGAFPDYE
610 620 630 640 650
RNADAMLRVM RNHRRAAHGL AEGYERLAVN PVPLKAEDCP DPALTAHARA
660 670 680 690 700
AWDRALELGQ KHGYRNAQAT VIAPTGTIGL VMDCDTTGIE PDFALVKFKK
710 720 730 740 750
LAGGGYFKII NRAVPEALRT LGYSESQIAE IEAYAVGHGN LNQAPGVNPS
760 770 780 790 800
TLKTKGFTDE KIAALNEALK SAFDIKFVFN QWTLGADWLK ETFGFTQDQL
810 820 830 840 850
DDFSFELLPA LGFSRKDIEA ANIHVCGAMT LEGAPHLKDE HLPVFDCANP
860 870 880 890 900
CGKIGKRYLS VESHIRMMAA AQPFISGAIS KTINMPNEAT VEDCKNAYML
910 920 930 940 950
SWKLALKANA LYRDGSKLSQ PLNSSLIADD EEEEDDAVEA LVAQPMAARA
960 970 980 990 1000
AQITEKIVER VIERVVRERE KLPNRRKGYT QKAVVGGHKV YLRTGEFDDG
1010 1020 1030 1040 1050
RLGEIFIDMH KEGAAFRAMM NNFAIAISLG LQYGVPLEEY VEAFTFTKFE
1060 1070 1080 1090 1100
PAGMVQGNDA IKNATSILDY VFRELAVSYL GRNDLAHVDT SDFDKTALGR
1110 1120 1130 1140 1150
GITEGKATPF SKGLYRGASP LKVVSGKTEP KGEASASPAR AQSAGSNVRA
1160 1170 1180 1190 1200
LSSGATVTAL KPAYAGLQEE ATAFRRDYEE RAKELAQEAA EEEGLNALFT
1210 1220 1230 1240 1250
EEAADEAAEA KKVESHRRQQ AIAQGYTGNM CSECQNFTMV RNGTCEKCDT

CGATSGCS
Length:1,258
Mass (Da):138,039
Last modified:August 22, 2006 - v1
Checksum:i6DB56C0BA718A70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG62728.1.
RefSeqiWP_011580671.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG62728; ABG62728; Meso_1332.
KEGGimes:Meso_1332.

Similar proteinsi

Entry informationi

Entry nameiQ11IP7_CHESB
AccessioniPrimary (citable) accession number: Q11IP7
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported