Q11HY2 (GLPK_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	Meso_1598

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Glycerol kinase HAMAP MF_00186		PRO_1000020745
Regions
	Nucleotide binding	411 – 415	5	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	16	1	ATP By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	243	1	Substrate By similarity
	Binding site	265	1	ATP By similarity
	Binding site	308	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11HY2 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 3E01253D5FD26CB4	FASTA	500	54,246
	10 20 30 40 50 60 MTGYILAIDQ GTTSSRAVIF DGAMKIVAVG QKEFPQHYPA SGWVEHDPED IWKSVVATVK 70 80 90 100 110 120 TALRKAKLEA SRITAIGITN QRETAVIWDR ATGMPIHNAI VWQDRRTAPL CAKLKKAGLE 130 140 150 160 170 180 PKFTRKTGLL LDPYFSGTKF AWLLDNVKGA RRRAEKGELL AGTIDTYLIW RLTGGRMHAT 190 200 210 220 230 240 DATNASRTLL YNISKNAWDA DLLKILRIPT ALLPEVKDCA AEFGVTEKKI FGAEIPILGV 250 260 270 280 290 300 AGDQQAATIG QACFEPGMLK STYGTGCFAV LNTGERLIRS KNRLLSTIAY RLDGKTTYAL 310 320 330 340 350 360 EGSIFIAGAA VQWLRDGIKV IGKAAESGAL AERSDETQQI YLVPAFVGLG APHWDADARG 370 380 390 400 410 420 AIFGLTRNSG PAEFARAALE SVAYQTHDLL VAMKRDCGNT FGKTVLRVDG GMVASSWTMQ 430 440 450 460 470 480 CLADILDAPV DSPTITETTA LGAAWLAGSK AGIWPDRATF AKSWALERRF EPQMDGRQRK 490 500 AKLAGWADAV SRTLTARAPC

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG62993.1.
RefSeq	YP_674158.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11HY2.
SMR	Q11HY2. Positions 4-494.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11HY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4180115.
GenomeReviews	Gene locus Meso_1598 in contig CP000390_GR.
KEGG	mes:Meso_1598.
NMPDR	fig|266779.1.peg.344.
PATRIC	21343244. VBICheSp72577_2250.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0554.
HOGENOM	HBG511469.
OMA	CYQTRDL.
PhylomeDB	Q11HY2.
ProtClustDB	CLSK863056.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_1598-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_MESSB

Accession

Primary (citable) accession number: Q11HY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program