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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP266779:GI09-2241-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Meso_2204
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293045Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_2204.

Structurei

3D structure databases

ProteinModelPortaliQ11G79.
SMRiQ11G79. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11G79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVKSDIEI ARAARKKPIQ EIGAGLGIAS EHLLPYGHDK AKVSAEFIAE
60 70 80 90 100
ARKRPDGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS
110 120 130 140 150
LGPCFGMKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLSALIDNH
160 170 180 190 200
IYWGNELGID TRRVTWRRVM DMNDRALREI VCSLGGVANG YPREGGFDIT
210 220 230 240 250
VASEVMAILC LAKDLGDLEK RLGDIIVAYR RDKSPVFARD LKADGAMAVL
260 270 280 290 300
LRDALQPNLV QTLENNPAFV HGGPFANIAH GCNSVMATST ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK TGLKPAAAVI VATVRALKMN GGVKKEDLGA
360 370 380 390 400
EDVDALIRGC ANLGRHIENI KQFGVPAIVA INHFETDTPA EIEAVRAYVG
410 420 430 440 450
AQGEEAVLCR HWAEGSAGIE ELAHKVVALA ESRASQFAPL YPDNMPLFEK
460 470 480 490 500
INTIVRRIYR GSRAVADGTV LAQLKQWEDQ GYGHLPVCMA KTQYSFSTDS
510 520 530 540 550
NLRGAPVDHV VPVREVRLSA GAGFVVAICG EIMTMPGLPR APSAEKIFLN

EAGYIEGLF
Length:559
Mass (Da):59,886
Last modified:August 22, 2006 - v1
Checksum:i0F1D840D1A791FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG63596.1.
RefSeqiWP_011581538.1. NC_008254.1.
YP_674761.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG63596; ABG63596; Meso_2204.
KEGGimes:Meso_2204.
PATRICi21344552. VBICheSp72577_2897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG63596.1.
RefSeqiWP_011581538.1. NC_008254.1.
YP_674761.1. NC_008254.1.

3D structure databases

ProteinModelPortaliQ11G79.
SMRiQ11G79. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266779.Meso_2204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG63596; ABG63596; Meso_2204.
KEGGimes:Meso_2204.
PATRICi21344552. VBICheSp72577_2897.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciCSP266779:GI09-2241-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiFTHS_CHESB
AccessioniPrimary (citable) accession number: Q11G79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.