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Q11G79

- FTHS_CHESB

UniProt

Q11G79 - FTHS_CHESB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP266779:GI09-2241-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Meso_2204
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293045Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_2204.

Structurei

3D structure databases

ProteinModelPortaliQ11G79.
SMRiQ11G79. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11G79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVKSDIEI ARAARKKPIQ EIGAGLGIAS EHLLPYGHDK AKVSAEFIAE
60 70 80 90 100
ARKRPDGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS
110 120 130 140 150
LGPCFGMKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLSALIDNH
160 170 180 190 200
IYWGNELGID TRRVTWRRVM DMNDRALREI VCSLGGVANG YPREGGFDIT
210 220 230 240 250
VASEVMAILC LAKDLGDLEK RLGDIIVAYR RDKSPVFARD LKADGAMAVL
260 270 280 290 300
LRDALQPNLV QTLENNPAFV HGGPFANIAH GCNSVMATST ALKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK TGLKPAAAVI VATVRALKMN GGVKKEDLGA
360 370 380 390 400
EDVDALIRGC ANLGRHIENI KQFGVPAIVA INHFETDTPA EIEAVRAYVG
410 420 430 440 450
AQGEEAVLCR HWAEGSAGIE ELAHKVVALA ESRASQFAPL YPDNMPLFEK
460 470 480 490 500
INTIVRRIYR GSRAVADGTV LAQLKQWEDQ GYGHLPVCMA KTQYSFSTDS
510 520 530 540 550
NLRGAPVDHV VPVREVRLSA GAGFVVAICG EIMTMPGLPR APSAEKIFLN

EAGYIEGLF
Length:559
Mass (Da):59,886
Last modified:August 22, 2006 - v1
Checksum:i0F1D840D1A791FED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG63596.1.
RefSeqiWP_011581538.1. NC_008254.1.
YP_674761.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG63596; ABG63596; Meso_2204.
GeneIDi4181898.
KEGGimes:Meso_2204.
PATRICi21344552. VBICheSp72577_2897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG63596.1 .
RefSeqi WP_011581538.1. NC_008254.1.
YP_674761.1. NC_008254.1.

3D structure databases

ProteinModelPortali Q11G79.
SMRi Q11G79. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266779.Meso_2204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG63596 ; ABG63596 ; Meso_2204 .
GeneIDi 4181898.
KEGGi mes:Meso_2204.
PATRICi 21344552. VBICheSp72577_2897.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CSP266779:GI09-2241-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiFTHS_CHESB
AccessioniPrimary (citable) accession number: Q11G79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3