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Q11G79

- FTHS_CHESB

UniProt

Q11G79 - FTHS_CHESB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP266779:GI09-2241-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Meso_2204
    OrganismiChelativorans sp. (strain BNC1)
    Taxonomic identifieri266779 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
    ProteomesiUP000001820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293045Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266779.Meso_2204.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11G79.
    SMRiQ11G79. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11G79-1 [UniParc]FASTAAdd to Basket

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    MADVKSDIEI ARAARKKPIQ EIGAGLGIAS EHLLPYGHDK AKVSAEFIAE    50
    ARKRPDGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
    LGPCFGMKGG AAGGGYAQVI PMEDINLHFT GDFHAVTSAH NLLSALIDNH 150
    IYWGNELGID TRRVTWRRVM DMNDRALREI VCSLGGVANG YPREGGFDIT 200
    VASEVMAILC LAKDLGDLEK RLGDIIVAYR RDKSPVFARD LKADGAMAVL 250
    LRDALQPNLV QTLENNPAFV HGGPFANIAH GCNSVMATST ALKLADYVVT 300
    EAGFGADLGA EKFFDIKCRK TGLKPAAAVI VATVRALKMN GGVKKEDLGA 350
    EDVDALIRGC ANLGRHIENI KQFGVPAIVA INHFETDTPA EIEAVRAYVG 400
    AQGEEAVLCR HWAEGSAGIE ELAHKVVALA ESRASQFAPL YPDNMPLFEK 450
    INTIVRRIYR GSRAVADGTV LAQLKQWEDQ GYGHLPVCMA KTQYSFSTDS 500
    NLRGAPVDHV VPVREVRLSA GAGFVVAICG EIMTMPGLPR APSAEKIFLN 550
    EAGYIEGLF 559
    Length:559
    Mass (Da):59,886
    Last modified:August 22, 2006 - v1
    Checksum:i0F1D840D1A791FED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG63596.1.
    RefSeqiWP_011581538.1. NC_008254.1.
    YP_674761.1. NC_008254.1.

    Genome annotation databases

    EnsemblBacteriaiABG63596; ABG63596; Meso_2204.
    GeneIDi4181898.
    KEGGimes:Meso_2204.
    PATRICi21344552. VBICheSp72577_2897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG63596.1 .
    RefSeqi WP_011581538.1. NC_008254.1.
    YP_674761.1. NC_008254.1.

    3D structure databases

    ProteinModelPortali Q11G79.
    SMRi Q11G79. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266779.Meso_2204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG63596 ; ABG63596 ; Meso_2204 .
    GeneIDi 4181898.
    KEGGi mes:Meso_2204.
    PATRICi 21344552. VBICheSp72577_2897.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CSP266779:GI09-2241-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BNC1.

    Entry informationi

    Entry nameiFTHS_CHESB
    AccessioniPrimary (citable) accession number: Q11G79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3