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Q11G79 (FTHS_MESSB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Meso_2204
OrganismMesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293045

Regions

Nucleotide binding68 – 758ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11G79 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 0F1D840D1A791FED

FASTA55959,886
        10         20         30         40         50         60 
MADVKSDIEI ARAARKKPIQ EIGAGLGIAS EHLLPYGHDK AKVSAEFIAE ARKRPDGRLI 

        70         80         90        100        110        120 
LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS LGPCFGMKGG AAGGGYAQVI 

       130        140        150        160        170        180 
PMEDINLHFT GDFHAVTSAH NLLSALIDNH IYWGNELGID TRRVTWRRVM DMNDRALREI 

       190        200        210        220        230        240 
VCSLGGVANG YPREGGFDIT VASEVMAILC LAKDLGDLEK RLGDIIVAYR RDKSPVFARD 

       250        260        270        280        290        300 
LKADGAMAVL LRDALQPNLV QTLENNPAFV HGGPFANIAH GCNSVMATST ALKLADYVVT 

       310        320        330        340        350        360 
EAGFGADLGA EKFFDIKCRK TGLKPAAAVI VATVRALKMN GGVKKEDLGA EDVDALIRGC 

       370        380        390        400        410        420 
ANLGRHIENI KQFGVPAIVA INHFETDTPA EIEAVRAYVG AQGEEAVLCR HWAEGSAGIE 

       430        440        450        460        470        480 
ELAHKVVALA ESRASQFAPL YPDNMPLFEK INTIVRRIYR GSRAVADGTV LAQLKQWEDQ 

       490        500        510        520        530        540 
GYGHLPVCMA KTQYSFSTDS NLRGAPVDHV VPVREVRLSA GAGFVVAICG EIMTMPGLPR 

       550 
APSAEKIFLN EAGYIEGLF 

« Hide

References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000390 Genomic DNA. Translation: ABG63596.1.
RefSeqYP_674761.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11G79.
SMRQ11G79. Positions 7-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266779.Meso_2204.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG63596; ABG63596; Meso_2204.
GeneID4181898.
KEGGmes:Meso_2204.
PATRIC21344552. VBICheSp72577_2897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycCSP266779:GI09-2241-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_MESSB
AccessionPrimary (citable) accession number: Q11G79
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways