Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q11ES4 (HEMH_MESSB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Meso_2724
OrganismMesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Ferrochelatase HAMAP MF_00323
PRO_1000116059

Sites

Metal binding2231Iron By similarity
Metal binding3041Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11ES4 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 11081121559B0E8A

FASTA35340,169
        10         20         30         40         50         60 
MTLERTGRDE EKALTQPPSG HSSVQAGKVG VLLVNLGTPD GTDYWPMRRY LGEFLSDRRV 

        70         80         90        100        110        120 
IEWPRAVWYP ILYGIILARR PKKSGALYAK IWNREQNESP LRTFTRAQGQ KLATALADKE 

       130        140        150        160        170        180 
NVIVDWAMRY GSPSIETVTK SLIERGCDRI VMFPLYPQYS ATTTATVNDK FFEALIEMRH 

       190        200        210        220        230        240 
QPAVRTVPAY PEEPVYIDAL VRSIERHLAT LDFEPEVVVA SYHGIPQSYA RRGDPYYEQC 

       250        260        270        280        290        300 
LATTARVRER LGWDEKKLIT TFQSRFGPEE WLQPYTDKTV EQLARDGVRS IAVINPGFVS 

       310        320        330        340        350 
DCLETLEEIA VEADRTFREA GGKNFTHIPC LNDSDEGMAV IESLIRREMS GWA

« Hide

References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000390 Genomic DNA. Translation: ABG64101.1.
RefSeqYP_675266.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11ES4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ11ES4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4180424.
GenomeReviewsGene locus Meso_2724 in contig CP000390_GR.
KEGGmes:Meso_2724.
NMPDRfig|266779.1.peg.1258.
PATRIC21345676. VBICheSp72577_3452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBQ11ES4.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycMSP266779:MESO_2724-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_MESSB
AccessionPrimary (citable) accession number: Q11ES4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents