Q11EH9 (XYLA_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Meso_2820

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Xylose isomerase HAMAP MF_00455		PRO_1000026446
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Metal binding	231	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 1 By similarity
	Metal binding	267	1	Magnesium 2 By similarity
	Metal binding	270	1	Magnesium 2 By similarity
	Metal binding	295	1	Magnesium 1 By similarity
	Metal binding	306	1	Magnesium 2 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	338	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11EH9 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 8222359A6A2DD1AD	FASTA	436	48,817
	10 20 30 40 50 60 MSTGFFGNLQ PISYEGPQSD NPLAFRHYNP DEVVLGKRLE DHLRFAVCYW HTFVWPGGDP 70 80 90 100 110 120 FGGQTFERPW FGDTMERARL KADVAFELFE ILGVPFFTFH DADVRPEGAS YSESVARLND 130 140 150 160 170 180 IADYIAAKME KTGVRLLWGT ANLFSHRRFM AGAATNPDPD VFAYAAATVK ACIDVTKRLN 190 200 210 220 230 240 GENYVLWGGR EGYETLLNTD LGRELDQLGR FLSMVVDYKH RIGFKGAILI EPKPQEPTKH 250 260 270 280 290 300 QYDFDVGTVY GFLKRYGLED EVKVNIEQGH ALLAGHSFEH ELALAATLGI FGSIDMNRND 310 320 330 340 350 360 YQSGWDTDQF PNNAPEAALA YYYILQAGGF TTGGTNFDAK LRRQSLDPED LVAAHIGGMD 370 380 390 400 410 420 ICAQGLKAAA RMIEDKALSG PLEERYSGWN ATEAQAMLKG ERSLEAIAER VARENLDPKP 430 RSGRQEKLEN IINRYV

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG64196.1.
RefSeq	YP_675361.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11EH9.
SMR	Q11EH9. Positions 4-436.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11EH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4179915.
GenomeReviews	Gene locus Meso_2820 in contig CP000390_GR.
KEGG	mes:Meso_2820.
NMPDR	fig|266779.1.peg.1352.
PATRIC	21345892. VBICheSp72577_3559.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
OMA	LLGWDTD.
PhylomeDB	Q11EH9.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_2820-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_MESSB

Accession

Primary (citable) accession number: Q11EH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program