ID   HUTH_MESSB              Reviewed;         511 AA.
AC   Q11E18;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Histidine ammonia-lyase;
DE            Short=Histidase;
DE            EC=4.3.1.3;
GN   Name=hutH; OrderedLocusNames=Meso_2985;
OS   Mesorhizobium sp. (strain BNC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Richardson P.;
RT   "Complete sequence of chromosome of Mesorhizobium sp. BNC1.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO),
CC       which is formed autocatalytically by cyclization and dehydration
CC       of residues Ala-Ser-Gly (By similarity).
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
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DR   EMBL; CP000390; ABG64357.1; -; Genomic_DNA.
DR   RefSeq; YP_675522.1; -.
DR   GeneID; 4181421; -.
DR   GenomeReviews; CP000390_GR; Meso_2985.
DR   KEGG; mes:Meso_2985; -.
DR   NMPDR; fig|266779.1.peg.1513; -.
DR   HOGENOM; Q11E18; -.
DR   OMA; Q11E18; AHMAAVM.
DR   BioCyc; MSP266779:MESO_2985-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016211; F:ammonia ligase activity; IEA:InterPro.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:HAMAP.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006548; P:histidine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00229; -; 1.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR001106; Phe/His_NH3-lyase.
DR   Pfam; PF00221; PAL; 1.
DR   TIGRFAMs; TIGR01225; hutH; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Lyase.
FT   CHAIN         1    511       Histidine ammonia-lyase.
FT                                /FTId=PRO_1000021560.
FT   MOD_RES     143    143       2,3-didehydroalanine (Ser) (By
FT                                similarity).
FT   CROSSLNK    142    144       5-imidazolinone (Ala-Gly) (By
FT                                similarity).
SQ   SEQUENCE   511 AA;  53243 MW;  B80D982815C6102C CRC64;
     MTIILHPGSV LLRDLATIYW TGVPARLDPS FDAGIVKAAD RIAEIAAGNA PVYGINTGFG
     KLASIKIDSA DVAALQRNLV LSHCCGVGEA LPENVVRLMM ALKLVSLGRG ASGVRLELVR
     LIEAMLARGV IPVIPEKGSV GASGDLAPLA HMAAVMMGHG EAFFGGERLN GATALLKAGL
     QPVELAAKEG LALINGTQTS TALALAGLFR AHRAAQSALI TGAMSTDAAM GSSAPFHPEI
     HTLRGHRGQI DTAEALRALL ENSPIRQSHI EGDERVQDPY CIRCQPQVDG ACLDLLRSVA
     RTLEIEANAV TDNPLVLSDN SVVAGGNFHA EPVAFAADQI VLAICEIGAI AQRRIALLVD
     PALSYGLPAF LAKKPGLNSG LMIAEVTSAA LMSENKQMSH PASVDSTPTS ANQEDHVSMA
     CHGARRLLPM TENLFAIIGI EALCAAQGVE LRAPLATSPE LTKAIAAIRN VVPSLEEDRY
     MANDLKAATV LIASGSLNES VSSGILPALE V
//