Reviewed, UniProtKB/Swiss-Prot Q11E17 (HUTI_MESSB)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Meso_2986

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Imidazolonepropionase HAMAP MF_00372		PRO_0000306473
Sites
	Metal binding	83	1	Zinc or iron By similarity
	Metal binding	85	1	Zinc or iron By similarity
	Metal binding	253	1	Zinc or iron By similarity
	Metal binding	328	1	Zinc or iron By similarity
	Binding site	92	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	188	1	Substrate By similarity
	Binding site	256	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11E17-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: D1324AD0C3186A5F	FASTA	417	44,374
	10 20 30 40 50 60 MTRNNFSGAA AHSARSIWRN GRLATLREDL QGLGIVENGA VVCEGGRILF AGPEGELPAE 70 80 90 100 110 120 LIENTEITDL EGRWVTPGLV DCHTHIVYGG NRAREFEMRL QGATYEEIAR AGGGIVSSVK 130 140 150 160 170 180 ATNALSVEGL VEAALPRLDT LISEGVTTVE IKSGYGLNIE AELKMLCAAR ALEQIRPVRV 190 200 210 220 230 240 VTSYLGAHAT PVEYKGRNGD YISEVVLPGL ERAHAEGLVD AVDGFCEGIA FSVDEIRRVF 250 260 270 280 290 300 DKARSLGIPV KLHAEQLSNL GGAKLAASYG ALSADHLEYL DEDGARAMAA AGTVAVLLPG 310 320 330 340 350 360 AFYAINEKQK PPVEALRQAG VHIAIATDSN PGTSPLTSLL LTMNMSATLF RLTVEECIAG 370 380 390 400 410 ATREGARALG LLAETGTIEA GKSADLAIWN IESPAELVYR IGFNPLHAHI FKGRRID

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000390 Genomic DNA. Translation: ABG64358.1.
RefSeq	YP_675523.1.
3D structure databases
SMR	Q11E17. Positions 14-416.
ModBase	Search...
Genome annotation databases
GeneID	4181422.
GenomeReviews	Gene locus Meso_2986 in contig CP000390_GR.
KEGG	mes:Meso_2986.
NMPDR	fig|266779.1.peg.1514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q11E17.
OMA	Q11E17. MNMACTL.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_2986-MON.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 2 hits. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_MESSB

Accession

Primary (citable) accession number: Q11E17

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)