Q11DS3 (GLO2_MESSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase
EC=3.1.2.6

Alternative name(s):
Glyoxalase II
Short name=Glx II

Gene names

Name:	gloB
Ordered Locus Names:	Meso_3080

Organism

Mesorhizobium sp. (strain BNC1) [Complete proteome] [HAMAP]

Taxonomic identifier

266779 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Chelativorans

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Hydroxyacylglutathione hydrolase HAMAP MF_01374		PRO_0000309660
Sites
	Metal binding	56	1	Zinc 1 By similarity
	Metal binding	58	1	Zinc 1 By similarity
	Metal binding	60	1	Zinc 2 By similarity
	Metal binding	61	1	Zinc 2 By similarity
	Metal binding	114	1	Zinc 1 By similarity
	Metal binding	133	1	Zinc 1 By similarity
	Metal binding	133	1	Zinc 2 By similarity
	Metal binding	171	1	Zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q11DS3 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 62D8501463ACDD68	FASTA	255	28,313
	10 20 30 40 50 60 MTLEIEQFMC RSDNFGILAR DSETGITALV DAPEEQAILE AIKRTGWTPS LLLITHHHAD 70 80 90 100 110 120 HVEANLALKE RFGLTIIGPA KEASKIPGID RQVNEGDVVR VGNQEARVIE TPGHTAGHIT 130 140 150 160 170 180 FYFAKAGIAF TADTLFALGC GRLFECKPPV MYESLKKLVE LPLETVIYCG HEYTESNARF 190 200 210 220 230 240 ALSVDPTNSA LKERAKKIEA LRREGRPTLP TTLGEEMATN PFLRCHDPVL RNNLGMKNAA 250 DVEVFAEIRK RKDVF

References

[1]

"Complete sequence of chromosome of Mesorhizobium sp. BNC1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BNC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000390 Genomic DNA. Translation: ABG64452.1.
RefSeq	YP_675617.1. NC_008254.1.
3D structure databases
ProteinModelPortal	Q11DS3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q11DS3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4183267.
GenomeReviews	Gene locus Meso_3080 in contig CP000390_GR.
KEGG	mes:Meso_3080.
NMPDR	fig|266779.1.peg.204.
PATRIC	21346428. VBICheSp72577_3819.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0491.
HOGENOM	HBG753931.
OMA	IGCGRVF.
PhylomeDB	Q11DS3.
ProtClustDB	CLSK863794.
Enzyme and pathway databases
BioCyc	MSP266779:MESO_3080-MONOMER.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLO2_MESSB

Accession

Primary (citable) accession number: Q11DS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program