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Q11DE4 (SYL_CHESB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Meso_3209
OrganismChelativorans sp. (strain BNC1) [Complete proteome] [HAMAP]
Taxonomic identifier266779 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans

Protein attributes

Sequence length871 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 871871Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009369

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif629 – 6335"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q11DE4 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: BCC50C7EB253FA83

FASTA87197,963
        10         20         30         40         50         60 
MATERYNPRT SEPRWQKAWE EARLFETKND DGRPTYYVLE MFPYPSGRIH IGHTRNYTMG 

        70         80         90        100        110        120 
DVVARYKRAK GYNVLHPMGW DAFGMPAENA AIQNKIHPKE WTYDNIATMR SQLKMMGLSL 

       130        140        150        160        170        180 
DWAREFATCD VDYYHRQQML FIDFYKKGLV RRKTSKVNWD PVEQTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GALVEQRELA QWFFKITDYA EDLLSAIDGL DDWPEKVRLM QRNWIGRSEG LSIRWALAED 

       250        260        270        280        290        300 
TAPAGVGELE VYTTRPDTIF GASFLAVAPD HPLARKAAEG NPALATFIEE CRHMGTSVAA 

       310        320        330        340        350        360 
LETAEKKGFD TGIRVKHPFD AEWTLPVYVA NFVLMEYGTG AIFGCPSGDQ RDFDFANKYG 

       370        380        390        400        410        420 
LPVIPVVMPE GADAATFEIT AEPYVDDGVM LNSRFLDGMS NKEAFEEVAS RLEKETLDGK 

       430        440        450        460        470        480 
PVAKRKVNFR LRDWGVSRQR YWGCPIPMIH CDTCGVVPVP KEELPVKLPD DVDFDRPGNP 

       490        500        510        520        530        540 
LDRHPTWRHV KCPQCGADAR RETDTMDTFV DSSWYFARFT SPHADSPVEK DVVNRWLPVD 

       550        560        570        580        590        600 
QYIGGIEHAI LHLLYSRFFT RAMRDTGHLD LAEPFKGLFT QGMVVHETYR AEDGRWLTPA 

       610        620        630        640        650        660 
EVRIEGSAGE RRAFEIATGK EVAIGPLEKM SKSKKNTVSP EDITESFGAD TARWFMLSDS 

       670        680        690        700        710        720 
PPERDVEWTD DGAAGAHRFV QRAWRLITEA APAIGDITPK AARDGDAAAI SKPAHKALKA 

       730        740        750        760        770        780 
VGEDIERLAF NRAIARIHEL VNDLQGPFAG LDKADEETRA AAREATEILI HLIAPFMPHL 

       790        800        810        820        830        840 
AEECWAAIGG KDLVAASRWP DFDPELVLDN LIVLPVQING KKRGDLTIAR EADQAAVEKA 

       850        860        870 
VLELDFVQKA LNGAPPRKVI VVSQRIVNVV A 

« Hide

References

[1]"Complete sequence of chromosome of Mesorhizobium sp. BNC1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BNC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000390 Genomic DNA. Translation: ABG64581.1.
RefSeqYP_675746.1. NC_008254.1.

3D structure databases

ProteinModelPortalQ11DE4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266779.Meso_3209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG64581; ABG64581; Meso_3209.
GeneID4182753.
KEGGmes:Meso_3209.
PATRIC21346710. VBICheSp72577_3959.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCSP266779:GI09-3266-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_CHESB
AccessionPrimary (citable) accession number: Q11DE4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries