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Q11DE4

- SYL_CHESB

UniProt

Q11DE4 - SYL_CHESB

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Protein
Leucine--tRNA ligase
Gene
leuS, Meso_3209
Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP266779:GI09-3266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Meso_3209
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Leucine--tRNA ligaseUniRule annotation
PRO_1000009369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_3209.

Structurei

3D structure databases

ProteinModelPortaliQ11DE4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi629 – 6335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11DE4-1 [UniParc]FASTAAdd to Basket

« Hide

MATERYNPRT SEPRWQKAWE EARLFETKND DGRPTYYVLE MFPYPSGRIH    50
IGHTRNYTMG DVVARYKRAK GYNVLHPMGW DAFGMPAENA AIQNKIHPKE 100
WTYDNIATMR SQLKMMGLSL DWAREFATCD VDYYHRQQML FIDFYKKGLV 150
RRKTSKVNWD PVEQTVLANE QVIDGRGWRS GALVEQRELA QWFFKITDYA 200
EDLLSAIDGL DDWPEKVRLM QRNWIGRSEG LSIRWALAED TAPAGVGELE 250
VYTTRPDTIF GASFLAVAPD HPLARKAAEG NPALATFIEE CRHMGTSVAA 300
LETAEKKGFD TGIRVKHPFD AEWTLPVYVA NFVLMEYGTG AIFGCPSGDQ 350
RDFDFANKYG LPVIPVVMPE GADAATFEIT AEPYVDDGVM LNSRFLDGMS 400
NKEAFEEVAS RLEKETLDGK PVAKRKVNFR LRDWGVSRQR YWGCPIPMIH 450
CDTCGVVPVP KEELPVKLPD DVDFDRPGNP LDRHPTWRHV KCPQCGADAR 500
RETDTMDTFV DSSWYFARFT SPHADSPVEK DVVNRWLPVD QYIGGIEHAI 550
LHLLYSRFFT RAMRDTGHLD LAEPFKGLFT QGMVVHETYR AEDGRWLTPA 600
EVRIEGSAGE RRAFEIATGK EVAIGPLEKM SKSKKNTVSP EDITESFGAD 650
TARWFMLSDS PPERDVEWTD DGAAGAHRFV QRAWRLITEA APAIGDITPK 700
AARDGDAAAI SKPAHKALKA VGEDIERLAF NRAIARIHEL VNDLQGPFAG 750
LDKADEETRA AAREATEILI HLIAPFMPHL AEECWAAIGG KDLVAASRWP 800
DFDPELVLDN LIVLPVQING KKRGDLTIAR EADQAAVEKA VLELDFVQKA 850
LNGAPPRKVI VVSQRIVNVV A 871
Length:871
Mass (Da):97,963
Last modified:August 22, 2006 - v1
Checksum:iBCC50C7EB253FA83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG64581.1.
RefSeqiWP_011582522.1. NC_008254.1.
YP_675746.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG64581; ABG64581; Meso_3209.
GeneIDi4182753.
KEGGimes:Meso_3209.
PATRICi21346710. VBICheSp72577_3959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG64581.1 .
RefSeqi WP_011582522.1. NC_008254.1.
YP_675746.1. NC_008254.1.

3D structure databases

ProteinModelPortali Q11DE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266779.Meso_3209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG64581 ; ABG64581 ; Meso_3209 .
GeneIDi 4182753.
KEGGi mes:Meso_3209.
PATRICi 21346710. VBICheSp72577_3959.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP266779:GI09-3266-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiSYL_CHESB
AccessioniPrimary (citable) accession number: Q11DE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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