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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP266779:GI09-3266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Meso_3209
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Leucine--tRNA ligasePRO_1000009369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_3209.

Structurei

3D structure databases

ProteinModelPortaliQ11DE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi629 – 6335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q11DE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATERYNPRT SEPRWQKAWE EARLFETKND DGRPTYYVLE MFPYPSGRIH
60 70 80 90 100
IGHTRNYTMG DVVARYKRAK GYNVLHPMGW DAFGMPAENA AIQNKIHPKE
110 120 130 140 150
WTYDNIATMR SQLKMMGLSL DWAREFATCD VDYYHRQQML FIDFYKKGLV
160 170 180 190 200
RRKTSKVNWD PVEQTVLANE QVIDGRGWRS GALVEQRELA QWFFKITDYA
210 220 230 240 250
EDLLSAIDGL DDWPEKVRLM QRNWIGRSEG LSIRWALAED TAPAGVGELE
260 270 280 290 300
VYTTRPDTIF GASFLAVAPD HPLARKAAEG NPALATFIEE CRHMGTSVAA
310 320 330 340 350
LETAEKKGFD TGIRVKHPFD AEWTLPVYVA NFVLMEYGTG AIFGCPSGDQ
360 370 380 390 400
RDFDFANKYG LPVIPVVMPE GADAATFEIT AEPYVDDGVM LNSRFLDGMS
410 420 430 440 450
NKEAFEEVAS RLEKETLDGK PVAKRKVNFR LRDWGVSRQR YWGCPIPMIH
460 470 480 490 500
CDTCGVVPVP KEELPVKLPD DVDFDRPGNP LDRHPTWRHV KCPQCGADAR
510 520 530 540 550
RETDTMDTFV DSSWYFARFT SPHADSPVEK DVVNRWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMRDTGHLD LAEPFKGLFT QGMVVHETYR AEDGRWLTPA
610 620 630 640 650
EVRIEGSAGE RRAFEIATGK EVAIGPLEKM SKSKKNTVSP EDITESFGAD
660 670 680 690 700
TARWFMLSDS PPERDVEWTD DGAAGAHRFV QRAWRLITEA APAIGDITPK
710 720 730 740 750
AARDGDAAAI SKPAHKALKA VGEDIERLAF NRAIARIHEL VNDLQGPFAG
760 770 780 790 800
LDKADEETRA AAREATEILI HLIAPFMPHL AEECWAAIGG KDLVAASRWP
810 820 830 840 850
DFDPELVLDN LIVLPVQING KKRGDLTIAR EADQAAVEKA VLELDFVQKA
860 870
LNGAPPRKVI VVSQRIVNVV A
Length:871
Mass (Da):97,963
Last modified:August 22, 2006 - v1
Checksum:iBCC50C7EB253FA83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG64581.1.
RefSeqiWP_011582522.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG64581; ABG64581; Meso_3209.
KEGGimes:Meso_3209.
PATRICi21346710. VBICheSp72577_3959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG64581.1.
RefSeqiWP_011582522.1. NC_008254.1.

3D structure databases

ProteinModelPortaliQ11DE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266779.Meso_3209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG64581; ABG64581; Meso_3209.
KEGGimes:Meso_3209.
PATRICi21346710. VBICheSp72577_3959.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCSP266779:GI09-3266-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiSYL_CHESB
AccessioniPrimary (citable) accession number: Q11DE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.