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Q11DE4

- SYL_CHESB

UniProt

Q11DE4 - SYL_CHESB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP266779:GI09-3266-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Meso_3209
    OrganismiChelativorans sp. (strain BNC1)
    Taxonomic identifieri266779 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
    ProteomesiUP000001820: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Leucine--tRNA ligasePRO_1000009369Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266779.Meso_3209.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11DE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q11DE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATERYNPRT SEPRWQKAWE EARLFETKND DGRPTYYVLE MFPYPSGRIH    50
    IGHTRNYTMG DVVARYKRAK GYNVLHPMGW DAFGMPAENA AIQNKIHPKE 100
    WTYDNIATMR SQLKMMGLSL DWAREFATCD VDYYHRQQML FIDFYKKGLV 150
    RRKTSKVNWD PVEQTVLANE QVIDGRGWRS GALVEQRELA QWFFKITDYA 200
    EDLLSAIDGL DDWPEKVRLM QRNWIGRSEG LSIRWALAED TAPAGVGELE 250
    VYTTRPDTIF GASFLAVAPD HPLARKAAEG NPALATFIEE CRHMGTSVAA 300
    LETAEKKGFD TGIRVKHPFD AEWTLPVYVA NFVLMEYGTG AIFGCPSGDQ 350
    RDFDFANKYG LPVIPVVMPE GADAATFEIT AEPYVDDGVM LNSRFLDGMS 400
    NKEAFEEVAS RLEKETLDGK PVAKRKVNFR LRDWGVSRQR YWGCPIPMIH 450
    CDTCGVVPVP KEELPVKLPD DVDFDRPGNP LDRHPTWRHV KCPQCGADAR 500
    RETDTMDTFV DSSWYFARFT SPHADSPVEK DVVNRWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMRDTGHLD LAEPFKGLFT QGMVVHETYR AEDGRWLTPA 600
    EVRIEGSAGE RRAFEIATGK EVAIGPLEKM SKSKKNTVSP EDITESFGAD 650
    TARWFMLSDS PPERDVEWTD DGAAGAHRFV QRAWRLITEA APAIGDITPK 700
    AARDGDAAAI SKPAHKALKA VGEDIERLAF NRAIARIHEL VNDLQGPFAG 750
    LDKADEETRA AAREATEILI HLIAPFMPHL AEECWAAIGG KDLVAASRWP 800
    DFDPELVLDN LIVLPVQING KKRGDLTIAR EADQAAVEKA VLELDFVQKA 850
    LNGAPPRKVI VVSQRIVNVV A 871
    Length:871
    Mass (Da):97,963
    Last modified:August 22, 2006 - v1
    Checksum:iBCC50C7EB253FA83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG64581.1.
    RefSeqiWP_011582522.1. NC_008254.1.
    YP_675746.1. NC_008254.1.

    Genome annotation databases

    EnsemblBacteriaiABG64581; ABG64581; Meso_3209.
    GeneIDi4182753.
    KEGGimes:Meso_3209.
    PATRICi21346710. VBICheSp72577_3959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG64581.1 .
    RefSeqi WP_011582522.1. NC_008254.1.
    YP_675746.1. NC_008254.1.

    3D structure databases

    ProteinModelPortali Q11DE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266779.Meso_3209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG64581 ; ABG64581 ; Meso_3209 .
    GeneIDi 4182753.
    KEGGi mes:Meso_3209.
    PATRICi 21346710. VBICheSp72577_3959.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSP266779:GI09-3266-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BNC1.

    Entry informationi

    Entry nameiSYL_CHESB
    AccessioniPrimary (citable) accession number: Q11DE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3