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Q11CT4

- PUR9_CHESB

UniProt

Q11CT4 - PUR9_CHESB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCSP266779:GI09-3480-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Meso_3420
    OrganismiChelativorans sp. (strain BNC1)
    Taxonomic identifieri266779 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
    ProteomesiUP000001820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Bifunctional purine biosynthesis protein PurHPRO_1000018908Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266779.Meso_3420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ11CT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q11CT4-1 [UniParc]FASTAAdd to Basket

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    MTVSAKNIPA PDLVPVRRAL ISVSDKTGIV DFARSLAARE VALASTGGTA    50
    ALLARSGIGV MDVSQLTGFP EIMDGRVKTL HPAVHGGLLA IRDDPDHRSA 100
    METHAIKPID LVVINLYPFE DVRFGGGDYA ATVENIDIGG PAMLRAAAKN 150
    HAYVAVVTDP ADYARVLEAL EKNDGALPYR LRQELAAKAY ARTAAYDAAI 200
    SQWFAESLAI AEPEWRSFGG RLAQVMRYGE NPHQQAGFYA TGEKRPGVAT 250
    ARQVQGKQLS YNNINDTDAA FELVCEFDPK KVAAVAIIKH ANPCGVAEGT 300
    SLAEAYRKAL ACDPVSAFGG IVALNRILDA EAAEEIAKIF TEVIIAPDAT 350
    EEAQAIIATK KNLRLLLTEG VADPRAPGLS AKTVAGGLLV QTRDNGVIDD 400
    LDLRVVTRRA PSEKEMANLK FAFRVAKHVK SNAIVYARDL ATVGIGAGQM 450
    SRVDSARIAA RKAEDAAAAA GGQPLTKGSV VASDAFFPFA DGLLSAVEAG 500
    ATAVIQPGGS MRDDEVIKAA DEHGIAMVFT GMRHFRH 537
    Length:537
    Mass (Da):56,842
    Last modified:August 22, 2006 - v1
    Checksum:i6A3FC694E5002FE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG64791.1.
    RefSeqiWP_011582732.1. NC_008254.1.
    YP_675956.1. NC_008254.1.

    Genome annotation databases

    EnsemblBacteriaiABG64791; ABG64791; Meso_3420.
    GeneIDi4183118.
    KEGGimes:Meso_3420.
    PATRICi21347164. VBICheSp72577_4184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000390 Genomic DNA. Translation: ABG64791.1 .
    RefSeqi WP_011582732.1. NC_008254.1.
    YP_675956.1. NC_008254.1.

    3D structure databases

    ProteinModelPortali Q11CT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266779.Meso_3420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG64791 ; ABG64791 ; Meso_3420 .
    GeneIDi 4183118.
    KEGGi mes:Meso_3420.
    PATRICi 21347164. VBICheSp72577_4184.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CSP266779:GI09-3480-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BNC1.

    Entry informationi

    Entry nameiPUR9_CHESB
    AccessioniPrimary (citable) accession number: Q11CT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3