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Q11CT4

- PUR9_CHESB

UniProt

Q11CT4 - PUR9_CHESB

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCSP266779:GI09-3480-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Meso_3420
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Bifunctional purine biosynthesis protein PurHPRO_1000018908Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_3420.

Structurei

3D structure databases

ProteinModelPortaliQ11CT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11CT4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVSAKNIPA PDLVPVRRAL ISVSDKTGIV DFARSLAARE VALASTGGTA
60 70 80 90 100
ALLARSGIGV MDVSQLTGFP EIMDGRVKTL HPAVHGGLLA IRDDPDHRSA
110 120 130 140 150
METHAIKPID LVVINLYPFE DVRFGGGDYA ATVENIDIGG PAMLRAAAKN
160 170 180 190 200
HAYVAVVTDP ADYARVLEAL EKNDGALPYR LRQELAAKAY ARTAAYDAAI
210 220 230 240 250
SQWFAESLAI AEPEWRSFGG RLAQVMRYGE NPHQQAGFYA TGEKRPGVAT
260 270 280 290 300
ARQVQGKQLS YNNINDTDAA FELVCEFDPK KVAAVAIIKH ANPCGVAEGT
310 320 330 340 350
SLAEAYRKAL ACDPVSAFGG IVALNRILDA EAAEEIAKIF TEVIIAPDAT
360 370 380 390 400
EEAQAIIATK KNLRLLLTEG VADPRAPGLS AKTVAGGLLV QTRDNGVIDD
410 420 430 440 450
LDLRVVTRRA PSEKEMANLK FAFRVAKHVK SNAIVYARDL ATVGIGAGQM
460 470 480 490 500
SRVDSARIAA RKAEDAAAAA GGQPLTKGSV VASDAFFPFA DGLLSAVEAG
510 520 530
ATAVIQPGGS MRDDEVIKAA DEHGIAMVFT GMRHFRH
Length:537
Mass (Da):56,842
Last modified:August 22, 2006 - v1
Checksum:i6A3FC694E5002FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG64791.1.
RefSeqiWP_011582732.1. NC_008254.1.
YP_675956.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG64791; ABG64791; Meso_3420.
GeneIDi4183118.
KEGGimes:Meso_3420.
PATRICi21347164. VBICheSp72577_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA. Translation: ABG64791.1 .
RefSeqi WP_011582732.1. NC_008254.1.
YP_675956.1. NC_008254.1.

3D structure databases

ProteinModelPortali Q11CT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266779.Meso_3420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG64791 ; ABG64791 ; Meso_3420 .
GeneIDi 4183118.
KEGGi mes:Meso_3420.
PATRICi 21347164. VBICheSp72577_4184.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CSP266779:GI09-3480-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiPUR9_CHESB
AccessioniPrimary (citable) accession number: Q11CT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3