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Q11CT4

- PUR9_CHESB

UniProt

Q11CT4 - PUR9_CHESB

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Meso_3420
Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCSP266779:GI09-3480-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Meso_3420
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
ProteomesiUP000001820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018908Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266779.Meso_3420.

Structurei

3D structure databases

ProteinModelPortaliQ11CT4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q11CT4-1 [UniParc]FASTAAdd to Basket

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MTVSAKNIPA PDLVPVRRAL ISVSDKTGIV DFARSLAARE VALASTGGTA    50
ALLARSGIGV MDVSQLTGFP EIMDGRVKTL HPAVHGGLLA IRDDPDHRSA 100
METHAIKPID LVVINLYPFE DVRFGGGDYA ATVENIDIGG PAMLRAAAKN 150
HAYVAVVTDP ADYARVLEAL EKNDGALPYR LRQELAAKAY ARTAAYDAAI 200
SQWFAESLAI AEPEWRSFGG RLAQVMRYGE NPHQQAGFYA TGEKRPGVAT 250
ARQVQGKQLS YNNINDTDAA FELVCEFDPK KVAAVAIIKH ANPCGVAEGT 300
SLAEAYRKAL ACDPVSAFGG IVALNRILDA EAAEEIAKIF TEVIIAPDAT 350
EEAQAIIATK KNLRLLLTEG VADPRAPGLS AKTVAGGLLV QTRDNGVIDD 400
LDLRVVTRRA PSEKEMANLK FAFRVAKHVK SNAIVYARDL ATVGIGAGQM 450
SRVDSARIAA RKAEDAAAAA GGQPLTKGSV VASDAFFPFA DGLLSAVEAG 500
ATAVIQPGGS MRDDEVIKAA DEHGIAMVFT GMRHFRH 537
Length:537
Mass (Da):56,842
Last modified:August 22, 2006 - v1
Checksum:i6A3FC694E5002FE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG64791.1.
RefSeqiWP_011582732.1. NC_008254.1.
YP_675956.1. NC_008254.1.

Genome annotation databases

EnsemblBacteriaiABG64791; ABG64791; Meso_3420.
GeneIDi4183118.
KEGGimes:Meso_3420.
PATRICi21347164. VBICheSp72577_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000390 Genomic DNA. Translation: ABG64791.1 .
RefSeqi WP_011582732.1. NC_008254.1.
YP_675956.1. NC_008254.1.

3D structure databases

ProteinModelPortali Q11CT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266779.Meso_3420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG64791 ; ABG64791 ; Meso_3420 .
GeneIDi 4183118.
KEGGi mes:Meso_3420.
PATRICi 21347164. VBICheSp72577_4184.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CSP266779:GI09-3480-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BNC1.

Entry informationi

Entry nameiPUR9_CHESB
AccessioniPrimary (citable) accession number: Q11CT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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