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Protein

Shikimate dehydrogenase (NADP(+))

Gene

aroE

Organism
Chelativorans sp. (strain BNC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).UniRule annotation

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64ShikimateUniRule annotation1
Active sitei68Proton acceptorUniRule annotation1
Binding sitei80NADPUniRule annotation1
Binding sitei89ShikimateUniRule annotation1
Binding sitei104ShikimateUniRule annotation1
Binding sitei218NADP; via carbonyl oxygenUniRule annotation1
Binding sitei220ShikimateUniRule annotation1
Binding sitei241NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi129 – 133NADPUniRule annotation5
Nucleotide bindingi153 – 158NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (NADP(+))UniRule annotation (EC:1.1.1.25UniRule annotation)
Short name:
SDHUniRule annotation
Gene namesi
Name:aroEUniRule annotation
Ordered Locus Names:Meso_3480
OrganismiChelativorans sp. (strain BNC1)
Taxonomic identifieri266779 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeChelativorans
Proteomesi
  • UP000001820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000212991 – 279Shikimate dehydrogenase (NADP(+))Add BLAST279

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266779.Meso_3480

Structurei

3D structure databases

ProteinModelPortaliQ11CM4
SMRiQ11CM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 20Shikimate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2X Bacteria
COG0169 LUCA
HOGENOMiHOG000237875
KOiK00014
OMAiFGNPIKH
OrthoDBiPOG091H02DY

Family and domain databases

HAMAPiMF_00222 Shikimate_DH_AroE, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR011342 Shikimate_DH
IPR013708 Shikimate_DH-bd_N
IPR022893 Shikimate_DH_fam
IPR006151 Shikm_DH/Glu-tRNA_Rdtase
PfamiView protein in Pfam
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00507 aroE, 1 hit

Sequencei

Sequence statusi: Complete.

Q11CM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESLHRAFI CGHPVAHSRS PVIHNFWLKQ HGIEGSYERR DIAPEAFSLF
60 70 80 90 100
IREFPRFYMG GNVTIPHKES AWRLVETRDE AAETIGAVNT LWLQDGRIMG
110 120 130 140 150
GNTDTYGFAA NLDMELAGWE KNAVATVLGA GGAALAVVHA LQSRGIRDIR
160 170 180 190 200
IVNRTVSRAR AVVDRFKGGT SAHAWEAVPD LLSDTSLLVN TTSLGMHGGP
210 220 230 240 250
EGHIDLAPLP DSAIVTDIVY VPLRTPLLAS AAARGLRTVD GLGMLLHQAV
260 270
PGFERWFGVR PEVTPHLREI VVADLEAGK
Length:279
Mass (Da):30,319
Last modified:August 22, 2006 - v1
Checksum:i199C7427D5DDFFFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000390 Genomic DNA Translation: ABG64851.1
RefSeqiWP_011582792.1, NC_008254.1

Genome annotation databases

EnsemblBacteriaiABG64851; ABG64851; Meso_3480
KEGGimes:Meso_3480

Similar proteinsi

Entry informationi

Entry nameiAROE_CHESB
AccessioniPrimary (citable) accession number: Q11CM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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