ID   SAHH_MESSB              Reviewed;         465 AA.
AC   Q11CD0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Adenosylhomocysteinase;
DE            EC=3.3.1.1;
DE   AltName: Full=S-adenosyl-L-homocysteine hydrolase;
DE            Short=AdoHcyase;
GN   Name=ahcY; OrderedLocusNames=Meso_3576;
OS   Mesorhizobium sp. (strain BNC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Richardson P.;
RT   "Complete sequence of chromosome of Mesorhizobium sp. BNC1.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-
CC       homocysteine + adenosine.
CC   -!- COFACTOR: Binds 1 NAD per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; homocysteine biosynthesis; L-
CC       homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
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DR   EMBL; CP000390; ABG64945.1; -; Genomic_DNA.
DR   RefSeq; YP_676110.1; -.
DR   GeneID; 4181405; -.
DR   GenomeReviews; CP000390_GR; Meso_3576.
DR   KEGG; mes:Meso_3576; -.
DR   NMPDR; fig|266779.1.peg.960; -.
DR   HOGENOM; Q11CD0; -.
DR   OMA; Q11CD0; HMRAMKD.
DR   BioCyc; MSP266779:MESO_3576-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:HAMAP.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00563; -; 1.
DR   InterPro; IPR000043; Ad_hcy_hydrolase.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   Gene3D; G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
DR   PANTHER; PTHR23420; Ad_hcy_hydrolase; 1.
DR   Pfam; PF05221; AdoHcyase; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   PIRSF; PIRSF001109; Ad_hcy_hydrolase; 1.
DR   TIGRFAMs; TIGR00936; ahcY; 1.
DR   PROSITE; PS00738; ADOHCYASE_1; 1.
DR   PROSITE; PS00739; ADOHCYASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
FT   CHAIN         1    465       Adenosylhomocysteinase.
FT                                /FTId=PRO_1000024731.
FT   REGION      218    383       NAD binding (By similarity).
FT   BINDING      56     56       Substrate (By similarity).
FT   BINDING     131    131       Substrate (By similarity).
FT   BINDING     191    191       Substrate (By similarity).
FT   BINDING     221    221       Substrate (By similarity).
FT   BINDING     225    225       Substrate (By similarity).
SQ   SEQUENCE   465 AA;  50894 MW;  2D5217D543BE535F CRC64;
     MAADDYVVAD MSLAAWGRKE IEIAETEMPG LMACREEFGE AKPLKGARIT GSLHMTIQTA
     VLIETLKSLG AEVRWASCNI FSTQDHAAAA IAETGTPVFA VKGETLEEYW TYTDRIFQWP
     DGQPSNMILD DGGDATMYIL LGARAEAGED VLSNPDGEEE EILFQQIKKR MAETPGFFTR
     QRAAIRGVTE ETTTGVNRLY QLQKKGLLPF PAINVNDSVT KSKFDNKYGC KESLVDGIRR
     ATDVMMAGKV AIVCGYGDVG KGSAQSLAGA GARVKVTEAD PICALQAAMD GFEVVTLDEA
     IATADIIITA TGNKDVVSLD HMRKMKDMVI LGNIGHFDNE IQVAALRNFK WVNIKPQVDL
     IEFPDGKRII LLSEGRLLNL GNATGHPSFV MSASFTNQVL AQIELWTRGS QYENKVYVLP
     KHLDEKVARL HLAKLGANLT KLSPEQAAYI GVTPEGPFKP DHYRY
//